1. Abstract Number ‐ 17: Robot‐assisted transcranial Doppler versus transthoracic echocardiography for right to left shunt detection: Final Results
- Author
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Mark N Rubin, Ruchir Shah, Thomas Devlin, Teddy S Youn, Michael Waters, John J Volpi, Aaron Stayman, Colleen Douville, Ted Lowenkopf, Georgios Tsivgoulis, and Andrei V Alexandrov
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction Right to left shunt (RLS), including patent foramen ovale (PFO), is a recognized risk factor for stroke. RLS/PFO diagnosis is made by transthoracic echocardiography (TTE) which is insensitive, transesophageal echocardiography (TEE) which is invasive, and transcranial Doppler (TCD) which is noninvasive and accurate but scarce. Methods We conducted a multi‐center device clinical trial of robot‐assisted TCD (raTCD) versus TTE for RLS diagnosis in patients who presented with an event suspicious for embolic cerebrovascular ischemia. raTCD was performed with standard TCD bubble study technique. TTE bubble study was performed to local standards. The primary outcome was rate of RLS detection by raTCD versus TTE. Results 133 patients were enrolled (intention to treat, ITT) and 126 subjects had complete data. In the ITT cohort, mean age was 60 +/‐ 15 years, 46% were women, and 92% of qualifying events were diagnosed as ischemic stroke. raTCD was positive for RLS in 82 subjects (64%) and TTE was positive in 26 (20%) [absolute difference 43.4% (95% CI 34.3%‐52.5%), p
- Published
- 2023
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