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Your search keyword '"Tazawa, Ichiro"' showing total 11 results
Start Over Author "Tazawa, Ichiro" Publisher wiley
11 results on '"Tazawa, Ichiro"'

5. Cryo‐injury procedure‐induced cardiac regeneration shows unique gene expression profiles in the newt Pleurodeles waltl

Author

Uemasu, Hitoshi, primary, Ikuta, Hiromi, additional, Igawa, Takeshi, additional, Suzuki, Makoto, additional, Kyakuno, Mitsuki, additional, Iwata, Yui, additional, Tazawa, Ichiro, additional, Ogino, Hajime, additional, Satoh, Yukio, additional, Takeuchi, Takashi, additional, Namba, Noriyuki, additional, and Hayashi, Toshinori, additional

Published
2021
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11. Cryo-injury procedure-induced cardiac regeneration shows unique gene expression profiles in the newt Pleurodeles waltl.

Author

Uemasu H, Ikuta H, Igawa T, Suzuki M, Kyakuno M, Iwata Y, Tazawa I, Ogino H, Satoh Y, Takeuchi T, Namba N, and Hayashi T

Subjects
Animals, Mice, Regeneration genetics, Salamandridae genetics, Transcriptome, Pleurodeles genetics, Zebrafish genetics
Abstract

Background: Cardiac regeneration in the adult mouse is not substantial. Some vertebrates, such as newts and zebrafish, regenerate the heart throughout their lives. To understand how regenerative abilities differ among animal species, comparative research has been conducted in animals like mouse, zebrafish, and newt. For those purposes, cryo-injury is suitable as an experimental model for the pathological condition of human myocardial infarction. In fact, cryo-injury procedures are common in mouse and zebrafish., Results: In the present study, we induced cryo-damage on the ventricle in Iberian ribbed newts using a liquid nitrogen-chilled probe. We observed that the injured area recovered within 8 weeks, with remodeling of scar tissue and proliferation of cardiomyocytes. We investigated the subsequent recovery of cryo-injured and amputated tissues by comparative analysis of the gene expression profiles following these two procedures., Conclusions: Notably, we established a cryo-injury procedure for the newt and confirmed that regeneration of the cryo-damaged myocardial tissue is achieved by changes in gene expression that are milder than those observed in the amputation model. Our results suggest that the cryo-injury method is suitable for comparing the process of cardiac regeneration in the newt with that in other animal models., (© 2021 American Association of Anatomists.)

Published
2022
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