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The epidermis of premetamorphic leptocephali of Japanese conger Conger myriaster consisted of only a few cell layers including congerin- (a galectin) containing club cells. The epidermis increased in thickness after metamorphosis, mainly due to a preponderant development of club cells. This suggested that the biological significance of congerins increased at this stage, which may be related to a change in life style. Epidermal mucous cells showed only limited distribution. Immuno-positive cells in the mucosal epithelia of the buccal cavity wall and oesophagus were not found in the youngest individuals. Though these cells were observed at the commencement of metamorphosis, the development of the epithelia and club cells was apparently retarded compared to that of the epidermis. No immuno-staining was found in the gills at any stages.

The objective of this study was to clarify the temporal change of muscle activity during relaxation of ipsilateral remote muscles. While participants maintained a constant right wrist extensor isometric force, they dorsiflexed the ipsilateral ankle from resting position or relaxed from dorsiflexed position in response to an audio signal. The wrist extensor force magnitude increased in the 0–400 msec period after the onset of foot contraction compared to that of the resting condition (P

Moloney murine sarcoma virus (M-MSV) was injected directly into the fetuses of Sprague-Dawley rats during the late stage of gestation and into the neonates within 24 hours after birth. Ninety rats developed 188 neoplastic lesions during the 8-week period of observation. Nearly all of the neoplasms were of mesenchymal derivation. Sixty percent of these neoplasms revealed more complex histologic features than those previously reported for neoplasms induced in rodents with M-MSV and were designated "malignant mesenchymoma" which developed preferentially in the proximal parts of the extremities, distant from the inoculation site. Rhabdomyosarcoma and osteosarcoma which developed in a pure form at the various sites were the next most common tumor type. Osteosarcoma developing in a pure form and as a component of malignant mesenchymoma in the humerus and femur was comparable to that of juxtacortical osteosarcoma of man; The development of excessive bones were observed in the forelimb and/or hind leg, suggesting a type of skeletal malformation. The reaction to M-MSV merits attention as a model for the study of an osteosarcoma and malignant mesenchymoma as well as rhabdomyosarcoma and also for the study of viral teratogenesis in man, as "rubella syndrome".