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8 results on '"Taima, Kageaki"'

2. Efficacy of pembrolizumab for patients with both high PD‐L1 expression and an MET exon 14 skipping mutation: A case report

Author

Baba, Keisuke, Tanaka, Hisashi, Sakamoto, Hiroaki, Shiratori, Toshihiro, Tsuchiya, Junichiro, Ishioka, Yoshiko, Itoga, Masamichi, Taima, Kageaki, and Tasaka, Sadatomo

Subjects
non‐small cell lung cancer, MET exon 14 skipping mutation, Case Report, Case Reports, pembrolizumab, pemetrexed, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, respiratory tract diseases, programmed death‐ligand 1
Abstract

Pembrolizumab has become the standard first‐line treatment for non‐small cell lung cancer (NSCLC) patients with high PD‐L1expression. MET exon 14 skipping is a rare mutation typically found in older, female, and non‐smoking patients with NSCLC. Herein, we report the case of a 71‐year‐old non‐smoking woman who was diagnosed with NSCLC in the left lung. EGFR mutation and ALK fusion were not detected. Because the biopsy specimen showed high PD‐L1 expression with a tumor proportion score of 95%, pembrolizumab was introduced as first‐line therapy, but resulted in no clinical benefit. The patient was subsequently administered chemotherapy with carboplatin and pemetrexed, leading to remarkable tumor shrinkage. A next‐generation sequencing panel analysis revealed a MET exon 14 skipping mutation. Thus, pembrolizumab might not be effective for NSCLC patients with MET exon 14 skipping mutations, even if PD‐L1 expression is high.

Published
2019

7. A pilot study of adjuvant chemotherapy with carboplatin and oral S‐1 for patients with completely resected stage II to IIIA non‐small cell lung cancer

Author

Tanaka, Hisashi, primary, Tabe, Chiori, additional, Okumura, Fumihiko, additional, Shiratori, Toshihiro, additional, Ishioka, Yoshiko, additional, Itoga, Masamichi, additional, Taima, Kageaki, additional, Morimoto, Takeshi, additional, Kimura, Daisuke, additional, Tsushima, Takao, additional, and Tasaka, Sadatomo, additional

Published
2020
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