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Your search keyword '"TESTAI, EMANUELA"' showing total 14 results
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14 results on '"TESTAI, EMANUELA"'

1. Risk Assessment Strategies for Contaminants in Seafood (RASCS)

Author

Diogène, Jorge, primary, Campàs, Mònica, additional, Rambla, Maria, additional, Rahmani, Djamel, additional, Reig, Lourdes, additional, Ramirez, Maria Saray, additional, Poyato, Cristina, additional, Gil, José Maria, additional, Marques, António, additional, Costa, Pedro, additional, Nunes, Maria Leonor, additional, Cardoso, Carlos, additional, Santos, Marta, additional, Maulvault, Ana Luísa, additional, Manganelli, Maura, additional, Scardala, Simona, additional, Testai, Emanuela, additional, Hung, Christine Yung, additional, Minnens, Fien, additional, Verbeke, Wim, additional, Dietrich, Jessica, additional, Lohmann, Mark, additional, Bodi, Dorina, additional, Spielmeyer, Astrid, additional, Arnich, Nathalie, additional, Biré, Ronel, additional, Sirot, Véronique, additional, and Thébault, Anne, additional

Published
2023
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2. Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems

Author

Testai, Emanuela, primary, Bechaux, Camille, additional, Buratti, Franca M., additional, Darney, Keyvin, additional, Di Consiglio, Emma, additional, Kasteel, Emma E.J., additional, Kramer, Nynke I., additional, Lautz, Leonie S., additional, Santori, Nicoletta, additional, Skaperda, Zoi‐Vasiliki, additional, Kouretas, Dimitrios, additional, Turco, Laura, additional, and Vichi, Susanna, additional

Published
2021
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4. Novel chemical hazard characterisation approaches

Author

Benfenati, Emilio, primary, Berggren, Elisabet, additional, Fritsche, Ellen, additional, Hartung, Thomas, additional, Slikker, William, additional, Spielmann, Horst, additional, Testai, Emanuela, additional, Tice, Raymond R., additional, Tiramani, Manuela, additional, and Villenave, Remi, additional

Published
2016
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8. GSTT1 andGSTM1 gene polymorphisms and gastric cancer in a high-risk italian population

Author

Palli, Domenico, primary, Saieva, Calogero, additional, Gemma, Simonetta, additional, Masala, Giovanna, additional, Gomez-Miguel, Maria Jesus, additional, Luzzi, Ida, additional, D'Errico, Mariarosaria, additional, Matullo, Giuseppe, additional, Ozzola, Giulio, additional, Manetti, Roberto, additional, Nesi, Gabriella, additional, Sera, Francesco, additional, Zanna, Ines, additional, Dogliotti, Eugenia, additional, and Testai, Emanuela, additional

Published
2005
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14. Malathion detoxification by human hepatic carboxylesterases and its inhibition by isomalathion and other pesticides.

Author

Buratti FM and Testai E

Subjects
Carboxylic Ester Hydrolases antagonists & inhibitors, Catalysis, Humans, Malathion pharmacology, Carboxylic Ester Hydrolases metabolism, Inactivation, Metabolic, Malathion pharmacokinetics, Microsomes, Liver enzymology, Pesticides pharmacology
Abstract

The organophosphorothioate (OPT) pesticide malathion (MAL) in mammals is readily hydrolyzed by mammalian carboxylesterases (CE). The reaction competes with the CYP-catalyzed formation of malaoxon (MOX), the toxic metabolite. Alterations or individual variations in CE activity may result in increased MOX formation, enhancing MAL toxicity. We have characterized the human hepatic CE activity in a panel of 18 human liver microsomes as well as the inhibitory effect of IsoMAL, a major impurity of MAL commercial formulations, parathion (PAR), chlorpyrifos (CPF), and chlorpyrifos-oxon (CPFO). CE activity showed a low level of variation among individuals (4-fold). The reaction consists of two different phases, differing in their affinity for mal (k(m1)=0.25-0.69 microm; K(m2)=10.3-26.8 microM). The relatively low K(m1) values confirmed that human CE efficiently detoxify MAL. IsoMAL was shown to be a potent noncompetitive inhibitor of MAL detoxification (K(i)=0.6 microM), with a higher inhibitory potency than CPF and PAR (K(i)=7.5 microM and 50 microM, respectively). These two latter compounds very likely act as mixed inhibitors. CPFO showed the highest inhibitory potency toward CE-mediated detoxification, being characterized by a K(i)=22 nM. The present results provide useful information for a better understanding of possible interactions between different OPTs and for assessing the potential cumulative risk for exposure to OPT mixtures., ((c) 2005 Wiley Periodicals, Inc. J Biochem Mol Toxicol 19:406-414, 2005)

Published
2005
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