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Your search keyword '"Swearingen, Christopher J"' showing total 11 results
Start Over Author "Swearingen, Christopher J" Publisher wiley
11 results on '"Swearingen, Christopher J"'

1. Associations of Cost Sharing With Rheumatoid Arthritis Disease Burden

Author

Dowell, Sharon, primary, Swearingen, Christopher J., additional, Pedra‐Nobre, Manuela, additional, Wollaston, Dianne, additional, Najmey, Sawsan, additional, Elliott, Cynthia Lawrence, additional, Ford, Theresa Lawrence, additional, North, Heather, additional, Dore, Robin, additional, Dolatabadi, Soha, additional, Ramanujam, Thaila, additional, Kennedy, Stacy, additional, Ott, Stephanie, additional, Jileaeva, Ilona, additional, Richardson, Amina, additional, Wright, Grace, additional, and Kerr, Gail S., additional

Published
2023
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2. Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial

Author

Yazici, Yusuf, primary, McAlindon, Timothy E., additional, Gibofsky, Allan, additional, Lane, Nancy E., additional, Clauw, Daniel, additional, Jones, Morgan, additional, Bergfeld, John, additional, Swearingen, Christopher J., additional, DiFrancesco, Anita, additional, Simsek, Ismail, additional, Tambiah, Jeyanesh, additional, and Hochberg, Marc C., additional

Published
2020
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3. Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

Author

Melchior, Benoît, primary, Mittapalli, Gopi Kumar, additional, Lai, Carolyn, additional, Duong‐Polk, Karen, additional, Stewart, Joshua, additional, Güner, Bora, additional, Hofilena, Brian, additional, Tjitro, Amanda, additional, Anderson, Scott D., additional, Herman, David S., additional, Dellamary, Luis, additional, Swearingen, Christopher J., additional, Sunil, K.C., additional, and Yazici, Yusuf, additional

Published
2019
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4. Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity

Author

Stine, Kimo C., primary, Wahl, Elizabeth C., additional, Liu, Lichu, additional, Skinner, Robert A., additional, VanderSchilden, Jaclyn, additional, Bunn, Robert C., additional, Montgomery, Corey O., additional, Aronson, James, additional, Becton, David L., additional, Nicholas, Richard W., additional, Swearingen, Christopher J., additional, Suva, Larry J., additional, and Lumpkin, Charles K., additional

Published
2016
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5. Cisplatin inhibits bone healing during distraction osteogenesis

Author

Stine, Kimo C., primary, Wahl, Elizabeth C., additional, Liu, Lichu, additional, Skinner, Robert A., additional, VanderSchilden, Jacquelyn, additional, Bunn, Robert C., additional, Montgomery, Corey O., additional, Suva, Larry J., additional, Aronson, James, additional, Becton, David L., additional, Nicholas, Richard W., additional, Swearingen, Christopher J., additional, and Lumpkin, Charles K., additional

Published
2013
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7. Reply

Author

Howard, Rennie G., primary, Pillinger, Michael H., additional, Gyftopoulos, Soterios, additional, Samuels, Jonathan, additional, Thiele, Ralf G., additional, and Swearingen, Christopher J., additional

Published
2012
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10. RAPID3 (Routine Assessment of Patient Index Data) on an MDHAQ (Multidimensional Health Assessment Questionnaire): Agreement with DAS28 (Disease Activity Score) and CDAI (Clinical Disease Activity Index) activity categories, scored in five versus more than ninety seconds

Author

Pincus, Theodore, primary, Swearingen, Christopher J., additional, Bergman, Martin J., additional, Colglazier, C. Lee, additional, Kaell, Alan T., additional, Kunath, Arthur M., additional, Siegel, Evan L., additional, and Yazici, Yusuf, additional

Published
2010
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11. Cisplatin inhibits bone healing during distraction osteogenesis.

Author

Stine KC, Wahl EC, Liu L, Skinner RA, Vanderschilden J, Bunn RC, Montgomery CO, Suva LJ, Aronson J, Becton DL, Nicholas RW, Swearingen CJ, and Lumpkin CK Jr

Subjects
Animals, Antineoplastic Agents administration & dosage, Cisplatin administration & dosage, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Tumor Necrosis Factor-alpha metabolism, Antineoplastic Agents toxicity, Bone Regeneration drug effects, Cisplatin toxicity, Osteogenesis, Distraction, Receptors, Tumor Necrosis Factor, Type I metabolism
Abstract

Osteosarcoma (OS) is the most common malignant bone tumor affecting children and adolescents. Many patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. Surgical reconstructions after tumor resection include structural allografts, non-cemented endoprostheses, and distraction osteogenesis (DO), which require direct bone formation. Although cisplatin (CDP) is extensively used for OS chemotherapy, the effects on bone regeneration are not well studied. The effects of CDP on direct bone formation in DO were compared using two dosing regimens and both C57BL/6 (B6) and tumor necrosis factor receptor 1 knockout (TNFR1KO) mice, as CDP toxicity is associated with elevated TNF levels. Detailed evaluation of the five-dose CDP regimen (2 mg/kg/day), demonstrated significant decreases in new bone formation in the DO gaps of CDP treated versus vehicle treated mice (p < 0.001). Further, no significant inhibitory effects from the five-dose CDP regimen were observed in TNFR1KO mice. The two-dose regimen significantly inhibited new bone formation in B6 mice. These results demonstrate that CDP has profound short term negative effects on the process of bone repair in DO. These data provide the mechanistic basis for modeling peri-operative chemotherapy doses and schedules and may provide new opportunities to identify molecules that spare normal cells from the inhibitory effects of CDP., (© 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)

Published
2014
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