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Background and objectives Combined sequential treatments with multiple modalities such as lasers and soft-tissue fillers are commonly required for the treatment of atrophic acne scars. Recently, fractional treatment with picosecond-domain lasers has proven to be effective for skin rejuvenation and scar treatment. However, little is known about the effects of picosecond-domain fractional laser treatment over hyaluronic acid fillers (HAFs). We aimed to evaluate the in vivo tissue responses to 1064 nm picosecond-domain fractional neodymium:yttrium-aluminum-garnet (Nd:YAG) laser treatments using microlens array (MLA) applied over pre-injected HAF in rats. In addition, we evaluated the efficacy and safety of this combined same-day treatment for atrophic acne scars in patients. Study design/materials and methods Sprague-Dawley rats were subjected to 1064 nm picosecond-domain fractional Nd:YAG laser treatment immediately after HAF dermal injection. Skin specimens were histologically evaluated on days 0, 7, and 21. In a clinical study, 36 patients with acne scars were treated concurrently with 1064 nm MLA-type picosecond lasers and HAFs. The patients were scheduled to receive two consecutive treatments at 4-week intervals, with a follow-up visit at 12 weeks after the final treatment. Acne scar photographs were graded using the Goodman and Baron's qualitative and quantitative scales at baseline and 12 weeks post-procedure. Results Picosecond-domain fractional laser treatment immediately after the dermal injection of HAF into rats did not cause any histological changes in the filler or surrounding skin. In a clinical study, treated subjects (n = 36) achieved significant improvement in acne scars and patient satisfaction. No serious adverse events were observed. Conclusions Combined picosecond laser and HAF treatment were proven to be safe and effective based on in vivo and clinical study results. Facial rejuvenation and scar treatment using a picosecond-domain fractional laser may be performed immediately after HAF injection. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

This study investigates the time‐varying Okun's law for different age and gender cohorts in South Korea over the 1980–2014 period. We found that the absolute value of the estimated Okun coefficients for all age cohorts and both genders become larger in a recession than in an expansion. We also found that the youth cohort (15–24 years old) for both genders is more sensitive to a negative economic impact than are older cohorts. These differences imply that when policymakers try to find a way of reducing the unemployment rate, they should consider differences in behaviour among these groups. Furthermore, the policies should be combined with age‐specific policies.

We develop several new time‐varying coefficient regression models to investigate herding behavior in Chinese stock markets. We find evidence that herding behavior occurs during turbulent periods rather than periods of relative tranquility, which does not appear when using a conventional fixed‐coefficient regression model. Moreover, the US return dispersion had a significant influence on Chinese stock markets before 2015 but not in 2015. Finally, the herding shows significant asymmetry.

This study investigates the causal relationship between investor sentiment and stock returns in the USA by conducting a quantile Granger non-causality test. Employing two proxies for investor sentiment – the sentiment index developed by Baker and Wurgler in 2007 and the University of Michigan Consumer Survey, a consumer confidence index – we find that the causal relationship between investor sentiment and stock returns strengthens when a tail quantile interval is considered. This finding implies that the investor sentiment could provide the incremental predictability for the stock returns under the extreme market situation, which cannot be found using a traditional Granger causality test. Interestingly, the findings can be explained by investors' loss aversion and herding behavior.

In this paper, we show that partial geometric designs can be constructed from certain three-class association schemes and ternary linear codes with dual distance three. In particular, we obtain a family of partial geometric designs from the three-class association schemes introduced by Kageyama, Saha, and Das in their article [“Reduction of the number of associate classes of hypercubic association schemes,” Ann Inst Statist Math 30 (1978)]. We also give a list of directed strongly regular graphs arising from the partial geometric designs obtained in this paper.

Many studies have estimated the optimal time-varying hedge ratio using futures, with most employing a bivariate generalized autoregressive conditional heteroscedasticity (BGARCH) model or a random coefficient model to estimate the time-varying hedge ratio. However, it has been argued that when the variability of the estimated time-varying hedge ratio is large, this ratio's hedging performance is not as good as that of the unconditional (constant) hedge ratio. This study proposes a nonparametric estimation approach to estimate and evaluate the optimal conditional hedge ratio. This method produces a time-varying hedge ratio with less volatility than those obtained from the BGARCH and random coefficient models. We evaluate the hedging performance of the various models using soybean oil, corn, S&P 500, and Hang Seng futures indices. The empirical results support the proposed nonparametric approach in terms of both in-sample and out-of-sample performance. © 2015 Wiley Periodicals, Inc. Jrl Fut Mark

We introduce the notion of a partial geometric difference family as a variation on the classical difference family and a generalization of partial geometric difference sets. We study the relationship between partial geometric difference families and both partial geometric designs and difference families, and show that partial geometric difference families give rise to partial geometric designs. We construct several infinite families of partial geometric difference families using Galois rings and the cyclotomy of Galois fields. From these partial geometric difference families, we generate a list of infinite families of partial geometric designs and directed strongly regular graphs.

In this paper, we present an on-line real-time physics-based approach to motion control with contact repositioning based on a low-dimensional dynamics model using example motion data. Our approach first generates a reference motion in run time according to an on-line user request by transforming an example motion extracted from a motion library. Guided by the reference motion, it repeatedly generates an optimal control policy for a small time window one at a time for a sequence of partially overlapping windows, each covering a couple of footsteps of the reference motion, which supports an on-line performance. On top of this, our system dynamics and problem formulation allow to derive closed-form derivative functions by exploiting the low-dimensional dynamics model together with example motion data. These derivative functions and their sparse structures facilitate a real-time performance. Our approach also allows contact foot repositioning so as to robustly respond to an external perturbation or an environmental change as well as to perform locomotion tasks such as stepping on stones effectively.

Summary Hyporesponsiveness to external signals, such as growth factors and apoptotic stimuli, is a cardinal feature of cellular senescence. We previously reported that an aging-dependent marked reduction in nucleocytoplasmic trafficking (NCT)-related genes could be responsible for this phenomenon. In searching for the mechanism, we identified the transcription factor, Sp1, as a common regulator of NCT genes, including various nucleoporins, importins, exportins, and Ran GTPase cycle-related genes. Sp1 knockdown led to a reduction of those genes in young human diploid fibroblast cells (HDF); Sp1 overexpression induced those genes in senescent cells. In addition, epidermal growth factor stimulation–induced p-ERK1/2 nuclear translocation and Elk-1 phosphorylation were severely impaired by Sp1 depletion in young HDFs; Sp1 overexpression restored the nuclear translocation of p-ERK1/2 in senescent HDFs. Furthermore, we observed that Sp1 protein levels were decreased in senescent cells, and H2O2 treatment decreased Sp1 levels in a proteasome-dependent manner. In addition, O-GlcNAcylation of Sp1 was decreased in senescent cells as well as in H2O2-treated cells. Taken together, these results suggest that Sp1 could be a key regulator in the control of NCT genes and that reactive oxygen species-mediated alteration in Sp1 stability may be responsible for the generalized repression of those genes, leading to formation of the senescence-dependent functional nuclear barrier, resulting in subsequent hyporesponsiveness to external signals.

Background Prurigo pigmentosa (PP) is an inflammatory dermatosis characterized by recurrent pruritic erythematous papules, mainly located on the trunk. It was first described by Nagashima in 1971 in Japan. Since then, more than 300 cases have been reported in Japan, but reports from other parts of the world are quite rare. Materials and methods We studied clinical and histopathological data from six patients with PP diagnosed in our hospital and 43 patients (18 reports) who were diagnosed with PP in Korea between 1988 and 2008. Results The number of Korean patients reported in recent years is higher than the number of other non-Japanese patients reported. Clinicopathological characteristics in Korean patients were not significantly different from those previously reported. Therapeutic results with minocycline were successful in our patients. Conclusions We suspect that PP is not uncommon in Korea, and the disease may be underestimated. Strict restriction of diet as well as known associated factors like wet condition are suggested as one of the important factors contributing to the occurrence of PP in Korea.

This article studies quantile regression in an autoregressive dynamic framework with exogenous stationary covariates. We demonstrate the potential of the quantile autoregressive distributed lag model with an application to house price returns in the United Kingdom. The results show that house price returns present a heterogeneous autoregressive behaviour across the quantiles. Real GDP growth and interest rates also have an asymmetric impact on house prices variations.

The objective of this study was to evaluate the antioxidant activities of pepsin-digested water-soluble protein (WSP) and salt-soluble protein (SSP) extracted from pork ham. WSP and SSP were hydrolysed by pepsin for 2-10 h with 2-h increments. The protein hydrolysates by pepsin were analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, and reducing power of the hydrolysates was measured. In addition, antioxidant activity of the hydrolysates was determined using linoleic acid emulsion system. Protein bands with molecular weight higher than 7 kDa in WSP and SSP were completely hydrolysed by pepsin after 2 h of digestion time. WSP hydrolysates (WSPH) and SSP hydrolysates (SSPH) had higher ferric reducing power than controls (WSP and SSP without pepsin digestion). Reducing powers of WSPH were higher than those of SSPH, regardless of digestion time. The oxidative activity of linoleic acid was predominantly inhibited by the addition of WSPH and SSPH, especially 0.5% protein hydrolysate. These results indicate that several functional peptides of pork protein digested by pepsin might have antioxidant activity, and thus they may be used as an antioxidant agent in muscle food system.

Summary Onions with or without heating (100 °C, 30 min) were extracted with water or methanol, and antioxidant and antimicrobial activities of onion extracts were evaluated. Product characteristics of fresh pork patties containing various onion extracts were measured during refrigerated storage. Water extracts of onions showed higher extraction yield and iron chelating ability than methanol extracts (P

Summary The objectives of this study were to screen the optimum conditions for antioxidant and antimicrobial activities of garlic as affected by pre-heating and different extraction solvents, and to evaluate the antioxidant and antimicrobial effects of these extracts in ground meat during refrigerated storage. Methanol extracted garlic had a greater total phenolic content, 1,1-diphenyl-2-picrylhydrazyl (DPPH)-radical scavenging activity and reducing power than water extracted one (P

Bollerslev's (1990, Review of Economics and Statistics, 52, 5–59) constant conditional correlation and Engle's (2002, Journal of Business & Economic Statistics, 20, 339–350) dynamic conditional correlation (DCC) bivariate generalized autoregressive conditional heteroskedasticity (BGARCH) models are usually used to estimate time-varying hedge ratios. In this study, we extend the above model to more flexible ones to analyze the behavior of the optimal conditional hedge ratio based on two (BGARCH) models: (i) adopting more flexible bivariate density functions such as a bivariate skewed-t density function; (ii) considering asymmetric individual conditional variance equations; and (iii) incorporating asymmetry in the conditional correlation equation for the DCC-based model. Hedging performance in terms of variance reduction and also value at risk and expected shortfall of the hedged portfolio are also conducted. Using daily data of the spot and futures returns of corn and soybeans we find asymmetric and flexible density specifications help increase the goodness-of-fit of the estimated models, but do not guarantee higher hedging performance. We also find that there is an inverse relationship between the variance of hedge ratios and hedging effectiveness. © 2009 Wiley Periodicals, Inc. Jrl Fut Mark 30:71–99, 2010

Purpose: To evaluate the basic characteristics and reproducibility of anterior chamber angle (ACA) measurements determined by anterior-segment optical coherence tomography (AS-OCT) in open-angle and primary angle closure suspect (PACS) patients. Methods: Thirty-nine open-angle and 18 PACS patients were imaged for ACA by AS-OCT. Subjects underwent imaging of the nasal, temporal and inferior ACA under conditions of constant light, and darkness. For analysis, we used three ACA parameters handled by the Visante OCT software: angle opening distance at 500 μm (AOD500), trabecular-iris space area at 500 μm (TISA500) and angle recess area at 500 μm (ARA500). For determination of inter-session reproducibility, a single well-trained operator (D.Y.K.) scanned all patients at two different visits. For determination of inter-operator variability, a second operator (S.B.P.) acquired another set of images independently. Three sets of images were acquired at least 24 hour apart. Results: All parameters were significantly different when measured both in light and darkness, and in the nasal and temporal quadrants. There were no significant differences between the left and right eyes in the three ACA parameters in all quadrants. The temporal angle was wider than the nasal and inferior angles. All parameters of the nasal, temporal angles had excellent inter-session and inter-operator reproducibility [intra-class correlation coefficient (ICC) 0.796–0.981], but these values were slightly lower for inferior angle measurements (ICC 0.662–0.892) in both open-angle and PACS groups. Conclusion: AS-OCT provides quantitative and reproducible assessment of ACA. Reproducibility was lower in the inferior angle compared with the nasal and temporal angles, perhaps because of variable placement of the scleral spur.

Ipriflavone, a derivative of naturally occurring isoflavones, was primarily metabolized in rats via hepatic CYP1A1/2 and 2C11. Protein and mRNA expression of CYP1A2 in the liver, reported to be increased in mutant Nagase analbuminemic rats (NARs), should influence the pharmacokinetic parameters of ipriflavone. In this study, the contribution of hepatic CYP2C11 and intestinal CYP1A protein to the metabolism and the pharmacokinetic parameters of ipriflavone were examined after intravenous (20 mg/kg) and oral (200 mg/kg) administration to male Sprague–Dawley (control) rats and NARs. There was no change in the protein expression of hepatic CYP2C11. By contrast, CYP1A protein of the intestine increased by almost 100%. After the intravenous administration of ipriflavone to NARs, the Clnr and AUC were unchanged, suggesting that the contribution of the increase in protein expression and mRNA level of hepatic CYP1A2 to hepatic metabolism of the drug in NARs seemed to be almost negligible. However, after the oral administration of ipriflavone to NARs, the AUC was significantly lower than that in the control rats (53.0% decrease), possibly due to the increased intestinal CYP1A that resulted in increased intestinal metabolism and decreased gastrointestinal absorption of ipriflavone in NARs. Copyright © 2009 John Wiley & Sons, Ltd.

Summary The study was performed to evaluate the flavour profiles of low-fat comminuted sausage (LFS) as affected by the addition of various concentrations of glucose, fructose and sucrose combined with 0.1 m lysine. Among thirty-five volatile compounds, the concentrations of furfural, 2-furan methanol, 2-methoxy phenol, 2-methoxy-4-methyl phenol, myristicine and pentadecanal occupied approximately 60% of the total concentration of volatile compounds identified in full- and low-fat smoked sausages. Phenols and hetero-compounds derived mainly from the smoking process were the predominant chemical groups. Nine volatile compounds were affected by fat content and the reduction of fat predominantly increased the headspace concentration of myristicin and pentadecanal. The headspace concentration of total volatile compounds detected in LFS control was significantly higher than those of LFS treatments with the various sugars and lysine. The headspace concentration of most volatile compounds decreased with the addition of various sugars. The results indicate that the addition of glucose, fructose and sucrose at the concentrations higher than 0.05 m in combination with 0.1 m lysine delays the release of some flavour compounds in LFS.

Summary Physicochemical and textural properties, and volatile compounds of comminuted sausages with various added fat levels and fat replacers were evaluated. Sausages without added fat had higher expressible moisture and texture values, but their lightness and yellowness values were lower, as compared with sausages with 5%, 10%, or 15% fat. Increased fat levels with constant amounts of lean meat and added water increased the lightness and yellowness values, but tended the redness values tended to be similar. Low-fat sausages (LFSs

Spinal dysraphism is a group of congenital anomalies involving incomplete midline closure of bony, neural, and soft tissue elements.1–5 The condition represents one of the more common congenital malformations in the Western world. The dysraphic states can be classified into open or closed forms. Open defects can be further subdivided into either meningoceles or myelomeningoceles, depending on whether or not these meninges lined defects contain neural tissue. The majority of these open dysplasias are associated with the Chiari II malformation, in which the posterior fossa contents are displaced into the upper spinal canal and accompanied by ventriculomegaly. In 1986, Nicolaides and associates described two characteristic cranial findings associated with the Chiari II malformation, the “lemon sign” and the “banana sign.”6 These signs have been shown to be very sensitive in the detection of Chiari malformations and the associated open form of spinal dysraphism. Occult dysraphic lesions, however, compose a more heterogeneous spectrum of abnormalities, including dermal sinus, lipomyelomeningocele, diastematomyelia, and various types of spinal lipomas. Unlike their open counterparts, these closed neurulation defects do not have accompanying cranial findings, making prenatal diagnosis more challenging. We present an unusual case of a lipomyelomeningocele with tethered cord, which was diagnosed on prenatal ultrasonography. An ultrasonogram showed the posterior fossa to be normal. The abnormality was identified only upon imaging of the lumbosacral spine.

It was reported that the area under the plasma concentration-time curve from time zero to time infinity (AUC) of parathion was significantly smaller, and the time-averaged total body clearance (Cl) of parathion was significantly faster after intravenous administration of parathion to rats pretreated with dexamethasone than those in control rats. This was supported by significantly faster intrinsic clearance of parathion to form paraoxon in hepatic microsomal fraction of rats pretreated with dexamethasone. The above data suggested that parathion was metabolized to paraoxon by dexamethasone-inducible hepatic cytochrome P450 (CYP) 3A in rats. The purpose of this study is to explain the protective effects of physostigmine against paraoxon toxicity by suppressing CYP3A, and hence, decreasing formation of a toxic metabolite, paraoxon. The pharmacokinetic changes of parathion and paraoxon were investigated after intravenous administration of parathion, 3 mg/kg, to control Sprague–Dawley rats, and the rats pretreated with physostigmine (100 µg/kg, intraperitoneal injection 30 min before parathion administration). After a 1-min intravenous infusion of parathion to rats pretreated with physostigmine, the AUC of parathion (60.4 compared with 73.7 µg min/mL) was significantly greater, Cl of parathion (49.7 compared with 40.7 mL/min/kg) was significantly slower, and amount of paraoxon recovered from liver, mesentery and large intestine at 5 min was smaller than those in control rats. Based on in vitro rat hepatic microsomal studies, physostigmine inhibited significantly the erythromycin N-demethylase activity (1.03 compared with 0.924 nmol/mg protein/min), mainly mediated by hepatic cytochrome P450 3A in rats. The above data suggested that the formation of paraoxon was inhibited in rats pretreated with physostigmine by inhibiting CYP3A. Copyright © 2000 John Wiley & Sons, Ltd.

The common neurological manifestations of pre-eclampsia include headache, confusion, and visual disturbance; while isolated abducens nerve palsy in pre-eclampsia is very rare. We report one case of a severe pre-eclampsia with abducens nerve palsy at 39 weeks' gestation. There was no specific pathology, except hypertension, and the palsy resolved spontaneously.

The ifosfamide metabolite isophosphoramide mustard (IPM) was synthesized with isotopic enrichment at oxygen. Labelled benzaldehyde was made by exchange with isotopically enriched water (13.4 atom % 170, 25.5 atom % 180) and this was then reduced with sodium borohydride to give labelled benzyl alcohol (72% yield). Triethylamine and labelled benzyl alcohol were added to POCl3/CHCl3 at −23°C. Subsequent addition of 2-chloroethylamine hydrochloride (2 equiv) and then triethylamine (4.4 equiv) (−15°C) provided 170/180 enriched N,N′-bs-(2-chloroethyl)phosphorodiamidic acid phenylmethyl ester [61%, BzOP(O)(NHCH2CH2Cl)2]. Catalytic (10% Pd/C) hydrogenation of this ester at atmospheric pressure gave IPM (22%). GC/MS was used to determine mole percent enrichments of 9.3% 170 and 17.9% 180 for IPM (single labelling within one molecule).