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Your search keyword '"Sonali Shaligram"' showing total 6 results
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6 results on '"Sonali Shaligram"'

1. Impaired Mesenteric Arterial Function of Male UC Davis Type 2 Diabetes Mellitus (UCD‐T2DM) Rats: Possible Involvement of Small Conductance Calcium‐activated Potassium Channels (SKca)

Author

Peter J. Havel, Roshanak Rahimian, James L. Graham, Sonali Shaligram, Kimber L. Stanhope, Der Yu Wang, Rahatullah Razan, and Farjana Akther

Subjects
medicine.medical_specialty, endocrine system diseases, business.industry, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, medicine.disease, Biochemistry, Calcium-activated potassium channel, Endocrinology, Internal medicine, Diabetes mellitus, Genetics, Etiology, Medicine, business, Molecular Biology, Arterial function, Biotechnology
Abstract

UC Davis type-2 diabetes mellitus (UCD-T2DM) model is a novel and validated model of type-2 diabetes exhibiting etiology very similar to clinical T2DM seen in humans. This model is characterized by...

Published
2018
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3. Consumption of High Fructose and Glucose Impairs Aortic Function in Female Rats

Author

Sonali Shaligram, Roshanak Rahimian, Farjana Akther, Marta Alegret, Juan C. Laguna, and Gemma Sangüesa

Subjects
Consumption (economics), medicine.medical_specialty, business.industry, medicine.disease, Biochemistry, Obesity, Endocrinology, Internal medicine, Diabetes mellitus, Genetics, medicine, High fructose, business, Molecular Biology, Function (biology), Biotechnology
Abstract

Intake of high fructose, especially in soft drinks, has shown to contribute to variety of metabolic disorders such as diabetes and obesity. The objective of this study was to compare the effects of...

Published
2015
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4. Comparison of High Fructose and Glucose Consumption on the Impairment of Mesenteric Arterial Function in Female Rats

Author

Gemma Sangüesa, Farjana Akther, Roshanak Rahimian, Sonali Shaligram, Marta Alegret, and Juan C. Laguna

Subjects
Consumption (economics), medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Genetics, medicine, High fructose, business, Molecular Biology, Biochemistry, Arterial function, Biotechnology
Published
2015
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5. Sex‐based alteration of relative importance of EDRFs in modulating vascular reactivity in Zucker diabetic fatty rats (1051.15)

Author

Leigh Anderson, Rui Zhang, Roshanak Rahimian, Sonali Shaligram, and Xiaoyuan Han

Subjects
medicine.medical_specialty, Endothelium-derived hyperpolarizing factor, Endothelium, biology, Stereochemistry, Biochemistry, Ouabain, Nitric oxide, Nitric oxide synthase, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Internal medicine, Genetics, medicine, biology.protein, Sodium nitroprusside, Molecular Biology, Phenylephrine, Mesenteric arteries, Biotechnology, medicine.drug
Abstract

Little is known about interaction of sex and diabetes in vasculature. Our study investigates the effects of type 2 diabetes on endothelium-dependent and -independent relaxations. Also, if there are sex-based changes in relative contributions of endothelium derived relaxing factors (EDRFs) in modulating vascular reactivity of mesenteric arteries (MA) from ZDF rats. Relaxation responses to acetylcholine (ACh) in MA pre-contracted with phenylephrine (PE) were obtained before and after pretreatment with indomethacin (cyclooxygenase inhibitor), L-NAME (nitric oxide synthase inhibitor) or barium chloride (Kir blocker) plus ouabain (Na+-K+-ATPase inhibitor). Vascular responses to sodium nitroprusside (SNP) were also measured in MA. ACh-induced relaxations were significantly impaired in MA of diabetic rats, regardless of sex. In diabetic females, the relative importance of endothelium derived hyperpolarizing factor (EDHF) in relaxation to ACh was reduced, while in diabetic males, role of nitric oxide (NO) was red...

Published
2014
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6. Sexual dimorphism in aortic endothelial function of Zucker diabetic fatty rats: possible involvement of superoxide production (1051.8)

Author

Leigh Anderson, Gemma Sangüesa, Roshanak Rahimian, Xiaoyuan Han, and Sonali Shaligram

Subjects
medicine.medical_specialty, Vasodilation, Biochemistry, chemistry.chemical_compound, Diabetes mellitus, Internal medicine, Genetics, medicine, Molecular Biology, Phenylephrine, NADPH oxidase, biology, business.industry, Superoxide, nutritional and metabolic diseases, medicine.disease, Sexual dimorphism, Endocrinology, chemistry, Apocynin, cardiovascular system, biology.protein, business, Acetylcholine, Biotechnology, medicine.drug
Abstract

Little is known about the interaction between diabetes and sex in vasculature. This study was designed to investigate whether there were sex differences in rat aortic endothelium-dependent vasodilation (EDV) in Zucker diabetic fatty (ZDF) rats, and the potential role of superoxide. EDV to acetylcholine (ACh) was measured in aortic rings pre-contracted with phenylephrine before and after pretreatment with apocynin (100 μM), a NADPH oxidase (Nox) inhibitor. In addition, the level of Nox (a potent source of superoxide) and PKCβ mRNA expression were determined using real-time RT-PCR. ACh-induced relaxations were significantly greater in female lean rats compared with male lean rats. Accordingly, male lean rats had higher PKCβI expression level than female lean rats. Diabetes significantly impaired EDV in aortic rings from female ZDF rats, however, potentiated the relaxation in males. Pre-incubation of aortic rings with apocynin increased EDV only in diabetic female group, suggesting impairment of EDV in femal...

Published
2014
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