1. Fetal fraction of cell‐free <scp>DNA</scp> in maternal plasma in the prediction of spontaneous preterm delivery
- Author
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Dan Dumitrascu-Biris, Carla Francisco, Maria Soledad Quezada, Kypros H. Nicolaides, and Leona Poon
- Subjects
Adult ,Male ,Fetal Membranes, Premature Rupture ,medicine.medical_specialty ,Gestational Age ,Crown-Rump Length ,Predictive Value of Tests ,Pregnancy ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Term delivery ,Preterm delivery ,Gynecology ,Fetus ,Cell-Free System ,Radiological and Ultrasound Technology ,business.industry ,Significant difference ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,DNA ,General Medicine ,Pregnancy Trimester, First ,Cross-Sectional Studies ,Reproductive Medicine ,Cell-free fetal DNA ,Premature Birth ,Gestation ,Female ,business ,Biomarkers ,Maternal Age - Abstract
Objectives To investigate whether, in pregnancies complicated by spontaneous preterm delivery, fetal fraction of cell-free DNA (cfDNA) in maternal plasma at 11–13 weeks' gestation is altered and if this measurement could be useful in the prediction of preterm delivery. Methods Fetal fraction of cfDNA was measured at 10 + 0 to 13 + 6 weeks' gestation in 3169 pregnancies, 3066 (96.7%) that delivered at ≥ 37 weeks and 103 (3.3%) with spontaneous delivery at
- Published
- 2014
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