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Your search keyword '"Slaney, Clare Y"' showing total 7 results
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7 results on '"Slaney, Clare Y"'

2. Enhancing chimeric antigen receptor T‐cell immunotherapy against cancer using a nanoemulsion‐based vaccine targeting cross‐presenting dendritic cells

Author

Chan, Jack D, primary, Scheidt, Bianca, additional, Zeng, Bijun, additional, Oliver, Amanda J, additional, Davey, Ashleigh S, additional, Ali, Aesha I, additional, Thomas, Ranjeny, additional, Trapani, Joseph A, additional, Darcy, Phillip K, additional, Kershaw, Michael H, additional, Dolcetti, Riccardo, additional, and Slaney, Clare Y, additional

Published
2020
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3. Novel combination immunotherapy for pancreatic cancer: potent anti‐tumor effects with CD40 agonist and interleukin‐15 treatment

Author

Van Audenaerde, Jonas RM, primary, Marcq, Elly, additional, Scheidt, Bianca, additional, Davey, Ashleigh S, additional, Oliver, Amanda J, additional, De Waele, Jorrit, additional, Quatannens, Delphine, additional, Van Loenhout, Jinthe, additional, Pauwels, Patrick, additional, Roeyen, Geert, additional, Lardon, Filip, additional, Slaney, Clare Y, additional, Peeters, Marc, additional, Kershaw, Michael H, additional, Darcy, Phillip K, additional, and Smits, Evelien LJM, additional

Published
2020
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4. Tissue‐specific tumor microenvironments influence responses to immunotherapies

Author

Oliver, Amanda J, primary, Davey, Ashleigh S, additional, Keam, Simon P, additional, Mardiana, Sherly, additional, Chan, Jack D, additional, Scheidt, Bianca, additional, Beavis, Paul A, additional, House, Imran G, additional, Van Audernaerde, Jonas RM, additional, Darcy, Phillip K, additional, Kershaw, Michael H, additional, and Slaney, Clare Y, additional

Published
2019
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7. Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity.

Author

Slaney CY, Toker A, La Flamme A, Bäckström BT, and Harper JL

Subjects
Animals, Antigens, Surface, CD11b Antigen immunology, Cell Communication immunology, Cell Proliferation, Encephalomyelitis, Autoimmune, Experimental immunology, Encephalomyelitis, Autoimmune, Experimental pathology, Lymphocyte Activation immunology, Mice, Mice, Inbred C57BL, Mice, Transgenic, Monocytes cytology, Nitric Oxide immunology, T-Lymphocytes cytology, Autoimmunity immunology, Monocytes immunology, T-Lymphocytes immunology
Abstract

In certain disease context, cells of the monocyte/macrophage lineage are known to exhibit T-cell suppressor function. However, whether naïve monocytes are also able to suppress T-cell responses has not been previously investigated. In this study, we have discovered that CD11b(+)Ly6G(-) mononuclear cells in the blood of naïve mice are potent suppressors of T-cell proliferation in vitro. The suppression of T-cell proliferation requires cell-cell contact and is partially dependent on nitric oxide production. Following the induction of experimental autoimmune encephalomyelitis in mice, the suppressor function of this blood CD11b(+)Ly6G(-) cell population is impaired. Therefore, blood CD11b(+)Ly6G(-) cells appear to be intrinsically suppressive and may have a key role in maintaining immune homoeostasis. Loss of this suppressive function may contribute to development of autoimmunity.

Published
2011
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