1. Drug resistance mutations after the first 12 months on antiretroviral therapy and determinants of virological failure in Rwanda
- Author
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Jamie I Forrest, Augustin Mulindabigwi, Sabin Nsanzimana, David J. Riedel, Marthe Kubwimana, Mutagoma Mwumvaneza, Jules Mugabo, Dieudone Sebuhoro, Sheila A. Peel, Jean Claude Uwimbabazi, Catherine M. Kirk, Jean d’Amour Ndahimana, Robert R. Redfield, Muhayimpundu Ribakare, Linda L. Jagodzinski, and Steve Kanters
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Genotype ,Anti-HIV Agents ,HIV Infections ,Drug resistance ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Antiretroviral Therapy, Highly Active ,Internal medicine ,Drug Resistance, Viral ,Odds Ratio ,Humans ,Medicine ,Treatment Failure ,030212 general & internal medicine ,Young adult ,Tenofovir ,Retrospective Studies ,business.industry ,Rwanda ,Public Health, Environmental and Occupational Health ,Retrospective cohort study ,Odds ratio ,Middle Aged ,Viral Load ,030112 virology ,Confidence interval ,CD4 Lymphocyte Count ,Surgery ,Regimen ,Logistic Models ,Infectious Diseases ,Mutation ,HIV-1 ,Female ,Parasitology ,business ,Viral load ,HIV drug resistance - Abstract
To evaluate HIV drug resistance (HIVDR) and determinants of virological failure in a large cohort of patients receiving first-line tenofovir-based antiretroviral therapy (ART) regimens.; A nationwide retrospective cohort from 42 health facilities was assessed for virological failure and development of HIVDR mutations. Data were collected at ART initiation and at 12 months of ART on patients with available HIV-1 viral load (VL) and ART adherence measurements. HIV resistance genotyping was performed on patients with VL ≥1000 copies/ml. Multiple logistic regression was used to determine factors associated with treatment failure.; Of 828 patients, 66% were women, and the median age was 37 years. Of the 597 patients from whom blood samples were collected, 86.9% were virologically suppressed, while 11.9% were not. Virological failure was strongly associated with age
- Published
- 2016