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Your search keyword '"Sharaf, Barry"' showing total 11 results
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11 results on '"Sharaf, Barry"'

3. An Intravascular Ultrasound Analysis in Women Experiencing Chest Pain in the Absence of Obstructive Coronary Artery Disease: A Substudy from the National Heart, Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)

Author

KHUDDUS, MATHEEN A., primary, PEPINE, CARL J., additional, HANDBERG, EILEEN M., additional, BAIREY MERZ, C. NOEL, additional, SOPKO, GEORGE, additional, BAVRY, ANTHONY A., additional, DENARDO, SCOTT J., additional, McGORRAY, SUSAN P., additional, SMITH, KAREN M., additional, SHARAF, BARRY L., additional, NICHOLLS, STEVEN J., additional, NISSEN, STEVEN E., additional, and ANDERSON, R. DAVID, additional

Published
2010
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4. Multimarker Approach Predicts Adverse Cardiovascular Events in Women Evaluated for Suspected Ischemia: Results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation

Author

Arant, Christopher B., primary, Wessel, Timothy R., additional, Ridker, Paul M., additional, Olson, Marian B., additional, Reis, Steven E., additional, Delia Johnson, B., additional, Sharaf, Barry L., additional, Pauly, Daniel F., additional, Handberg, Eileen, additional, Zineh, Issam, additional, Sopko, George, additional, Kelsey, Sheryl F., additional, Noel Bairey Merz, C., additional, and Pepine, Carl J., additional

Published
2009
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5. Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE)

Author

Wessel, Timothy R., primary, Arant, Christopher B., additional, McGorray, Susan P., additional, Sharaf, Barry L., additional, Reis, Steven E., additional, Kerensky, Richard A., additional, von Mering, Gregory O., additional, Smith, Karen M., additional, Pauly, Daniel F., additional, Handberg, Eileen M., additional, Mankad, Sunil, additional, Olson, Marian B., additional, Johnson, B. Delia, additional, Bairey Merz, C. Noel, additional, Sopko, George, additional, and Pepine, Carl J., additional

Published
2007
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6. Electrocardiogram abnormalities predict angiographic coronary artery disease in women with chest pain: Results from the nhlbi wise study

Author

Holubkov, Richard, primary, Pepine, Carl J., additional, Rickens, Cheryl R., additional, Reichek, Nathaniel, additional, Rogers, William J., additional, Sharaf, Barry L., additional, Sopko, George, additional, Noel Merz, C. Bairey, additional, Kelsey, Sheryl F., additional, Olson, Marian, additional, Smith, Karen M., additional, and Reis, Steven E., additional

Published
2002
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10. Factors Influencing Clinical Outcomes After Revascularization in the Asymptomatic Cardiac Ischemia Pilot (ACIP)

Author

Pepine, Carl J., primary, Bourassa, Martial G., additional, Chaitman, Bernard R., additional, Davies, Richard F., additional, Kerensky, Richard A., additional, Sharaf, Barry, additional, Knatterud, Genell L., additional, Forman, Sandra A., additional, Pratt, Craig M., additional, Staples, Edward D., additional, Sopko, George, additional, and Conti, C. Richard, additional

Published
1985
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11. Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHLBI-Sponsored Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD).

Author

Anderson RD, Petersen JW, Mehta PK, Wei J, Johnson BD, Handberg EM, Kar S, Samuels B, Azarbal B, Kothawade K, Kelsey SF, Sharaf B, Shaw LJ, Sopko G, Bairey Merz CN, and Pepine CJ

Subjects
Cohort Studies, Coronary Angiography methods, Coronary Vessels physiopathology, Female, Humans, Middle Aged, National Heart, Lung, and Blood Institute (U.S.), Prognosis, Risk Factors, United States epidemiology, Endothelium, Vascular physiopathology, Microvessels physiopathology, Myocardial Ischemia diagnosis, Myocardial Ischemia epidemiology, Myocardial Ischemia physiopathology
Abstract

Objective: In a separate, contemporary cohort, we sought to confirm findings of the original Women's Ischemia Syndrome Evaluation (WISE)., Background: The original WISE observed a high prevalence of both invasively determined coronary endothelial and coronary microvascular dysfunction (CMD) that predicted adverse events in follow-up., Methods: We comparatively studied the WISE-Coronary Vascular Dysfunction (CVD) cohort (2009-2011), with signs and symptoms of ischemia but without significant CAD, to the original WISE (1997-2001) cohort. CMD was defined as coronary flow reserve (CFR) ≤2.5, or endothelial dysfunction as epicardial coronary artery constriction to acetylcholine (ACH), or <20% epicardial coronary dilation to nitroglycerin (NTG)., Results: In WISE (n=181) and WISE-CVD (n=235) women, mean age in both was 54 years, and 83% were white (WISE) vs 74% (WISE-CVD, p=0.04). Use of hormone replacement therapy was less frequent in WISE-CVD vs WISE (46% vs 57%, p=0.026) as was presence of hypertension (40% vs 52%, p=0.013), hyperlipidemia (20% vs 46%, p<0.0001), and smoking (46% vs 56%, p=0.036). Similar rates were observed in WISE-CVD and WISE cohorts for CMD (mean CFR 2.7±0.6 vs 2.6±0.8, p=0.35), mean change in diameter with intracoronary ACH (0.2±10.0 vs 1.6±12.8 mm, p=0.34), and mean change in diameter with intracoronary NTG (9.7±13.0 vs 9.8±13.5 mm, p=0.94), respectively., Conclusions: This study confirms prevalence of CMD in the contemporary WISE-CVD cohort similar to that of the original WISE cohort, despite a lower risk factor burden in WISE-CVD. Because these coronary functional abnormalities predict major adverse cardiac events, clinical trials of therapies targeting these abnormalities are indicated., Competing Interests: There are no relevant conflicts of interest of any of the authors to disclose., (Copyright © 2019 R. David Anderson et al.)

Published
2019
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