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When considering the requirements of a chemistry lab, it is important to remember that chemistry is a multifaceted discipline with many different sub domains, and the potential to be used in conjunction with other scientific disciplines in interdisciplinary research. This section will detail the different aspects of addressing the lab requirements: Including the contrasting types of chemistry lab, barriers to adoption of increased digitisation, the different stages of digitisation and the level of digitisation requirements at each stage. Approaches to digitising the lab will be covered in the next section.

Managing public health risks from environmental contaminants has historically relied on a risk assessment process defined by the regulatory context in which these risks are assessed. Risk assessment guidance follows a straightforward, chemical-by-chemical approach to inform regulatory decisions around the question “what is the risk-based concentration protective of human and ecological health outcomes?” Here we briefly summarize regulatory risk assessment in the context of innovative risk assessment approaches based on an evolving understanding of the underlying scientific disciplines that support risk analysis more broadly. We discuss scientific versus regulatory tensions in the application of these approaches for future risk assessments, and challenges in translating our improved understanding of the underlying scientific complexity to the regulatory landscape to better inform decision making that extends beyond conventional regulatory mandates.

The amplification of nucleic acids is a fundamental tool utilized in various scientific disciplines, including Molecular Biology, Immunology, Microbiology, and Genetics. However, due to the time and technology required for traditional polymerase chain reaction and its derivatives, it is not always possible to include such methodologies in undergraduate laboratory curricula. Loop-mediated isothermal amplification (LAMP), a technology that has become increasingly utilized in a variety of laboratory and field settings during the past two decades, is an alternate method of nucleic acid amplification that is rapid, sensitive, and performed under isothermal conditions. We describe an adaptable, inquiry-driven laboratory module that is focused on the detection of Escherichia coli DNA via LAMP amplification. The main objectives of the module are to introduce students to the principles and protocols of LAMP, to help students develop the ability to apply the scientific method to scientific questions, to guide students as they develop the ability to identify the most appropriate methodology to use in the investigation of scientific questions, and to train students to critically evaluate scientific data, theories, and principles and to articulate their evaluations in both written and oral formats.

Incorporation of non-equilibrium actions in the sequence of self-assembly processes would be an effective means to establish bio-like high functionality hierarchical assemblies. As a novel methodology beyond self-assembly, nanoarchitectonics, which has as its aim the fabrication of functional materials systems from nanoscopic units through the methodological fusion of nanotechnology with other scientific disciplines including organic synthesis, supramolecular chemistry, microfabrication, and bio-process, has been applied to this strategy. The application of non-equilibrium factors to conventional self-assembly processes is discussed on the basis of examples of directed assembly, Langmuir-Blodgett assembly, and layer-by-layer assembly. In particular, examples of the fabrication of hierarchical functional structures using bio-active components such as proteins or by the combination of bio-components and two-dimensional nanomaterials, are described. Methodologies described in this review article highlight possible approaches using the nanoarchitectonics concept beyond self-assembly for creation of bio-like higher functionalities and hierarchical structural organization.

Background Theory-based interventions have been recommended to target relevant issues and improve outcomes in children and adolescents with Type 1 diabetes. Furthermore, the timing of interventions has been recognized as key to improving outcomes, suggesting a need to focus on preteens (9-12 years old) with Type 1 diabetes. The aim of the present study was to identify the theories that inform interventions targeting preteens with Type 1 diabetes and to analyse the studies for their understandings of theory. Methods We conducted a systematic literature review of intervention studies targeting preteens with Type 1 diabetes to identify the theoretical frameworks applied. Seven databases across different scientific disciplines were searched for papers published between 1995 and 2018. Results Twenty-four studies were included in the review. Of these, 14 were categorized as theory-inspired and 10 as theory-related studies. Social cognitive theory appeared most frequently. Most studies did not provide a rationale for their choice and application of theory to inform interventions. The studies were characterized by use of adult-centric theories and a focus on the relationships between children and their parents. Conclusions The present review shows variations and limitations in the description and application of theories across interventions targeting preteens with Type 1 diabetes. This emphasizes the need for future studies to address for what reason and how a certain theory or method is applied. We suggest that interventions might benefit from using theories that are centred on the needs and experiences of children, target family dynamics that include all important family members, and address the mutually constitutive relationship between interventions and the social context in which they are implemented.

Research communication in interdisciplinary research projects requires a way of demarcation of theory and knowledge that is easy to communicate, is inconsequential for the framework of concepts, results, and procedures within existing scientific disciplines, and abstains from trying to resolve the dispute between (neo)positivists and constructivists. A simple way of demarcation starts from the notion of language‐independent and language‐dependent reality. Currently, what passes for knowledge (“news”) and myth (“fake news”) depends, besides on sheer volume and frequency of the messages, increasingly on the internal consistency of (computer) language‐dependent reality and decreasingly on language‐independent reality. All language is instruction, and knowledge is to know which instructions (that is, theory) are predictive of a result, state, or situation in language‐independent reality. Any theory that doesn’t reduce outcome space, or contains one or more empirically/physically impossible instructions, or produces wrong predictions, or falls short of demonstration is not knowledge.

Neurons are highly polarized cells that critically depend on long-range, bidirectional transport between the cell body and synapse for their function. This continual and highly coordinated trafficking process, which takes place via the axon, has fascinated researchers since the early 20th century. Ramon y Cajal first proposed the existence of axonal trafficking of biological material after observing that dissociation of the axon from the cell body led to neuronal degeneration. Since these first indirect observations, the field has come a long way in its understanding of this fundamental process. However, these advances in our knowledge have been aided by breakthroughs in other scientific disciplines, as well as the parallel development of novel tools, techniques and model systems. In this review, we summarize the evolution of tools used to study axonal transport and discuss how their deployment has refined our understanding of this process. We also highlight innovative tools currently being developed and how their addition to the available axonal transport toolkit might help to address key outstanding questions.

The movement for open access publishing (OA) is often said to have its roots in the scientific disciplines, having been popularized by scientific publishers and formalized through a range of top‐down policy interventions. But there is an often‐neglected prehistory of OA that can be found in the early DIY publishers of the late 1980s and early 1990s. Managed entirely by working academics, these journals published research in the humanities and social sciences and stand out for their unique set of motivations and practices. This article explores this separate lineage in the history of the OA movement through a critical‐theoretical analysis of the motivations and practices of the early scholar‐led publishers. Alongside showing the involvement of the humanities and social sciences in the formation of OA, the analysis reveals the importance that these journals placed on experimental practices, critique of commercial publishing, and the desire to reach new audiences. Understood in today's context, this research is significant for adding complexity to the history of OA, which policymakers, advocates, and publishing scholars should keep in mind as OA goes mainstream.

The ability to adequately pump blood throughout the body is the result of tightly regulated feedback mechanisms that exist across many spatial scales in the heart. Diseases which impede the function at any one of the spatial scales can cause detrimental cardiac remodeling and eventual heart failure. An overarching goal of cardiac research is to use engineered heart tissue in vitro to study the physiology of diseased heart tissue, develop cell replacement therapies, and explore drug testing applications. A commonality within the field is to manipulate the flow of mechanical signals across the various spatial scales to direct self-organization and build functional tissue. Doing so requires an understanding of how chemical, electrical, and mechanical cues can be used to alter the cellular microenvironment. We discuss how mathematical models have been used in conjunction with experimental techniques to explore various structure-function relations that exist across numerous spatial scales. We highlight how a systems biology approach can be employed to recapitulate in vivo characteristics in vitro at the tissue, cell, and subcellular scales. Specific focus is placed on the interplay between experimental and theoretical approaches. Various modeling methods are showcased to demonstrate the breadth and power afforded to the systems biology approach. An overview of modeling methodologies exemplifies how the strengths of different scientific disciplines can be used to supplement and/or inspire new avenues of experimental exploration. This article is categorized under: Models of Systems Properties and Processes > Mechanistic Models Models of Systems Properties and Processes > Cellular Models Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models.

Because of a greater coverage of documentary sources in many languages that is greater than that of traditional bibliographic databases, Google Scholar is an ideal tool for examining the social sciences in non‐Anglophone countries. We have therefore used it to study the scholarly output and impact of three scientific disciplines, management, economics, and sociology, in Spain and France, comparing some of the results with those retrieved with Scopus. Our findings show that scientific articles are the predominant form of scholarly communication in Google Scholar for our selected fields and countries. In addition, our results indicate that in Google Scholar the vernacular languages of each country are more used than English in all cases, but economics in France. The opposite occurs in Scopus, except for the case of sociology articles in France We also show that books receive on average more citations than other published documents in Google Scholar. Finally, we demonstrate that publishing in English is associated with greater scholarly impact, except for the case of France in Google Scholar for articles in sociology and books in the three fields.

Nanographene, a small piece of graphene, has attracted unprecedented interest across diverse scientific disciplines particularly in organic electronics. The biological applications of nanographenes, such as bioimaging, cancer therapies and drug delivery, provide significant opportunities for breakthroughs in the field. However, the intrinsic aggregation behavior and low solubility of nanographenes, which stem from their flat structures, hamper their development for bioapplications. Herein, we report a water‐soluble warped nanographene (WNG) that can be easily synthesized by sequential regioselective C−H borylation and cross‐coupling reactions of the saddle‐shaped WNG core structure. The saddle‐shaped structure and hydrophilic tetraethylene glycol chains impart high water solubility to the WNG. The water‐soluble WNG possesses a range of promising properties including good photostability and low cytotoxicity. Moreover, the water‐soluble WNG was successfully internalized into HeLa cells and promoted photoinduced cell death., ファイル公開：2019-03-05

Direct Volume Rendering (DVR) provides the possibility to visualize volumetric data sets as they occur in many scientific disciplines. With DVR semi-transparency is facilitated to convey ...

Integrated pest management (IPM) is a broad-based approach for addressing pests that negatively affect human and environmental health and economic profitability. Weeds, insects and disease-causing pathogens (diseases) are the pests most often associated with IPM. A systematic review, widely used in other scientific disciplines, was employed to determine the most commonly studied IPM topics and summarize the reasons for these trends and the gaps. In a field synopsis of the literature, 1679 relevant published papers were identified and categorized into one of the following five broad areas: IPM and organic (organic), climate change and pests (climate), rural and urban IPM (rural and urban), next-generation education (education) and advanced production systems (technology). Papers were examined in greater detail for at least one of the three main pests in a systematic review. A majority (85%) of IPM papers have been in the area of rural and urban IPM, primarily addressing agriculture (78%). Professionals, landowners and the general public were the focus of a majority (95%) of IPM papers on education. Technology is an increasing area of focus in the literature. Over the past 40 years, IPM papers have primarily (75%) addressed insects and been limited mostly to rural and urban settings. Climate change, technology and education specific to pest management studies are increasingly being published and will help broaden the focus that could result in increased adoption and development of IPM. © 2017 Society of Chemical Industry.

Prior research on proenvironmental and prosocial behavior focuses primarily on explaining consistent rather than paradoxical tendencies. Even though this field receives wide attention from different scientific disciplines, findings for many causal factors of such proenvironmental orientation are contradictory. Nevertheless, knowing who those individuals are who think and behave in a pro-/antienvironmental way or show a paradoxical behavior in this regard becomes useful for many different parties in human societies including public policy makers, governmental and nongovernmental environmental protection organizations, and for-profit firms. Therefore, this study identifies those individuals who show neither consistent proenvironmental nor consistent antienvironmental tendencies as the “walkers-only” and “talkers-only” (i.e., for short, “walkers” and “talkers”). The former are defined as persons who put much effort into the recycling of waste materials but do not support pollution standards, whereas the latter term describes individuals who have a strong opinion with regard to the support of pollution standards yet do not engage in recycling efforts. The present study reports evidence of the existence of walkers and talkers. Further, this research is the first study to employ “fuzzy-set qualitative comparative analysis” to identify the complex antecedent conditions for some individuals’ paradoxical belief–behaviors in the field of socially and environmentally directed behaviors and orientations. The findings yield valuable insights both into the applicability and benefits of configural analysis and for public policy makers and managers in waste management and recycling industries.

In the last century, human scalp hair morphology has been studied from multiple, and sometimes mutually exclusive, perspectives by anthropologists, biologists, geneticists, forensic scientists, and cosmetic scientists. Here, we review and synthesize historical and current research on hair to better understand the scientific basis and biological implications of hair microstructure and morphology. We revisit the origins of existing nomenclature regarding hair morphology and classifications, discuss the currently recognized limitations to hair analysis within the varied scientific disciplines studying hair, point out aspects of hair biology that remain unknown, and the great potential for integrating these diverse perspectives and expertise in future scientific investigations, while highlighting the benefits of combining nondestructive microscopical analysis with chemical and genomic analyses for explicating hair biology. Further, we propose consensus terminology for root growth stages through descriptions and images that will aid in the morphological and microscopical analysis of human scalp hair, thereby reducing confusion and the promulgation of inaccurate information that is presently in the literature.

The objective of science is to understand the natural world; we argue that prediction is the only way to demonstrate scientific understanding, implying that prediction should be a fundamental aspect of all scientific disciplines. Reproducibility is an essential requirement of good science and arises from the ability to develop models that make accurate predictions on new data. Ecology, however, with a few exceptions, has abandoned prediction as a central focus and faces its own crisis of reproducibility. Models are where ecological understanding is stored and they are the source of all predictions – no prediction is possible without a model of the world. Models can be improved in three ways: model variables, functional relationships among dependent and independent variables, and in parameter estimates. Ecologists rarely test to assess whether new models have made advances by identifying new and important variables, elucidating functional relationships, or improving parameter estimates. Without these tests it is difficult to know if we understand more today than we did yesterday. A new commitment to prediction in ecology would lead to, among other things, more mature (i.e. quantitative) hypotheses, prioritization of modeling techniques that are more appropriate for prediction (e.g. using continuous independent variables rather than categorical) and, ultimately, advancement towards a more general understanding of the natural world. Synthesis Ecology, with a few exceptions, has abandoned prediction and therefore the ability to demonstrate understanding. Here we address how this has inhibited progress in ecology and explore how a renewed focus on prediction would benefit ecologists. The lack of emphasis on prediction has resulted in a discipline that tests qualitative, imprecise hypotheses with little concern for whether the results are generalizable beyond where and when the data were collected. A renewed commitment to prediction would allow ecologists to address critical questions about the generalizability of our results and the progress we are making towards understanding the natural world.

Despite rapid progress both in psychology and neuroimaging, there is still a convergence gap between the results of these two scientific disciplines. This is particularly unsatisfactory, as the variability between single subjects needs to be understood both for basic science and for patient diagnostics in, for example, the field of age-related cognitive changes. Active and passive behaviors are the observables in psychology and can be studied alone or in combination with the neuroimaging approach. Various physical signatures of brain activity are the observables in neuroimaging and can be measured concurrent with behaviors. Despite the intrinsic relationship between behaviors and the corresponding neuroimaging patterns and the obvious advantages in integrating behavioral and neuroimaging measurements, the results of combined studies can be difficult to interpret. Experiments are often optimized to yield either a novel behavioral or a novel physiological result, but rarely designed for a better match between the two. Since integrating the results is probably a key to future progress in clinical psychology and basic research, an attempt is made here to identify some difficulties and to provide some ideas for future research.

Esophageal disorders are common in diabetes mellitus (DM) patients. DM induces mechanostructural remodeling in the esophagus of humans and animal models. The remodeling is related to esophageal sensorimotor abnormalities and to symptoms frequently encountered by DM patients. For example, gastroesophageal reflux disease (GERD) is a common disorder associated with DM. This review addresses diabetic remodeling of esophageal properties and function in light of the Esophagiome, a scientifically based modeling effort to describe the physiological dynamics of the normal, intact esophagus built upon interdisciplinary approaches with applications for esophageal disease. Unraveling the structural, biomechanical, and sensory remodeling of the esophagus in DM must be based on a multidisciplinary approach that can bridge the knowledge from a variety of scientific disciplines. The first focus of this review is DM-induced morphodynamic and biomechanical remodeling in the esophagus. Second, we review the sensorimotor dysfunction in DM and how it relates to esophageal remodeling. Finally, we discuss the clinical consequences of DM-induced esophageal remodeling, especially in relation to GERD. The ultimate aim is to increase the understanding of DM-induced remodeling of esophageal structure and sensorimotor function in order to assist clinicians to better understand the esophageal disorders induced by DM and to develop better treatments for those patients.

This review presents the contributions of research on the intersection of science and social movements, its theoretical and methodological limitations, and potential solutions for its further development. Three different types of relationships between activism and knowledge have been identified within environmental health conflicts: (i) lay – activists requesting help from sympathetic scientists in order to conduct independent studies; (ii) expert – activists promoting new research agendas and sub-fields within established scientific disciplines; and (iii) expert – activists acting beyond the limits of the academic community and partnering with social movements. In this review, I argue that much of the existing literature considers expertise as “something” possessed by individuals, and heavily emphasizes the difference between “lay” and “expert” activists. This entails two main theoretical reductionisms: (i) reification of knowledge; and (ii) overlooking the contribution of activism to expertise and vice versa. I propose considering expertise as the property of a network and focusing future research within environmental health conflicts on the co-emergence and construction of a network of expertise (Eyal 2013) or ethno-epistemic assemblage (Irwin & Michael 2003) and social movements. Through this symmetrical network approach, we will be able to develop a more consistent theory of the co-production of activism and expertise, as well as its political implication to fight environmental health injustice.

Forensic toxicology and environmental water analysis share the common interest and responsibility in ensuring comprehensive and reliable confirmation of drugs and pharmaceutical compounds in samples analyzed. Dealing with similar analytes, detection and identification techniques should be exchangeable between scientific disciplines. Herein, we demonstrate the successful adaption of a forensic toxicological screening workflow employing nontargeted LC/MS/MS under data-dependent acquisition control and subsequent database search to water analysis. The main modification involved processing of an increased sample volume with SPE (500 mL vs. 1-10 mL) to reach LODs in the low ng/L range. Tandem mass spectra acquired with a qTOF instrument were submitted to database search. The targeted data mining strategy was found to be sensitive and specific; automated search produced hardly any false results. To demonstrate the applicability of the adapted workflow to complex samples, 14 wastewater effluent samples collected on seven consecutive days at the local wastewater-treatment plant were analyzed. Of the 88,970 fragment ion mass spectra produced, 8.8% of spectra were successfully assigned to one of the 1040 reference compounds included in the database, and this enabled the identification of 51 compounds representing important illegal drugs, members of various pharmaceutical compound classes, and metabolites thereof.

A new information literacy test ILT for higher education was developed, tested, and validated. The ILT contains 40 multiple-choice questions available in Appendix with four possible answers and follows the recommendations of information literacy IL standards for higher education. It assesses different levels of thinking skills and is intended to be freely available to educators, librarians, and higher education managers, as well as being applicable internationally for study programs in all scientific disciplines. Testing of the ILT was performed on a group of 536 university students. The overall test analysis confirmed the ILT reliability and discrimination power as appropriate Cronbach's alpha 0.74; Ferguson's delta 0.97. The students' average overall achievement was 66%, and IL increased with the year of study. The students were less successful in advanced database search strategies, which require a combination of knowledge, comprehension, and logic, and in topics related to intellectual property and ethics. A group of 163 students who took a second ILT assessment after participating in an IL-specific study course achieved an average posttest score of 78.6%, implying an average IL increase of 13.1%, with most significant improvements in advanced search strategies 23.7%, and in intellectual property and ethics 12.8%.

Editorial Forest ecosystems cover approximately 30 % of the terrestrial area of the Earth, and are expected to play crucial roles in regulating our environments including biodiversity and atmospheric CO2 concentration. As the structure and functions of the forest ecosystems are consists of multiple interactions of organisms, soil chemistry and meteorological conditions, which are quite variable in time and space, challenges to understand their processes and resulting dynamics of the functions have been made by various scientific disciplines/techniques such as ecology (including eco

The Habermasian concept of 'interest' has had a profound effect on the characterization of scientific disciplines. Going beyond issues unrelated to the theory itself, intra-theoretical interest characterizes the specific ways of approaching any science-related discipline, defining research topics and methodologies. This approach was developed by Jurgen Habermas in relation to empirical-analytical sciences, historical-hermeneutics sciences, and critical sciences; however, he did not make any specific references to health sciences. This article aims to contribute to shaping a general epistemological framework for health sciences, as well as its specific implications for the medical and nursing areas, via an analysis of the basic knowledge interests developed by Habermas.

Street networks, as one of the oldest infrastructures of transport in the world, play a significant role in modernization, sustainable development, and human daily activities in both ancient and modern times. Although street networks have been well studied in a variety of engineering and scientific disciplines, including for instance transport, geography, urban planning, economics, and even physics, our understanding of street networks in terms of their structure and dynamics remains limited, especially when dealing with such real-world problems as traffic jams, pollution, and human evacuations for disaster management. One goal of this special issue is to promote different ways of thinking about understanding street networks, and of conducting spatial analysis.

Summary According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20th century, cell culture and ex vivo organ preservation studies by Alexis Carrel, some with famed aviator Charles Lindbergh, established a foundation for much of modern regenerative medicine. While early beliefs and discoveries foreshadowed significant accomplishments in regenerative medicine, advances in knowledge within numerous scientific disciplines, as well as nano- and micromolecular level imaging and detection technologies, have contributed to explosive advances over the last 20 years. Virtually limitless preparations, combinations and applications of the 3 major components of regenerative medicine, namely cells, biomaterials and bioactive molecules, have created a new paradigm of future therapeutic options for most species. It is increasingly clear, however, that despite significant parallels among and within species, there is no ‘one-size-fits-all’ regenerative therapy. Likewise, a panacea has yet to be discovered that completely reverses the consequences of time, trauma and disease. Nonetheless, there is no question that the promise and potential of regenerative medicine have forever altered medical practices. The horse is a relative newcomer to regenerative medicine applications, yet there is already a large body of work to incorporate novel regenerative therapies into standard care. This review focuses on the current state and potential future of stem cells in equine regenerative medicine.

The promise of “big data” is a grand one. The collection and aggregation of massive datasets and the development of analytical tools by which to study these data is part of cutting-edge efforts across scientific disciplines, with social, behavioral, and economic sciences leading the way in many of these efforts. There has been a recent rise in National Science Foundation funding for “big data” research across directorates that coincides with scholarly, public, and governmental attention to the topic. Nonetheless, there are limitations and trade-offs to “big data” research, particularly as it corresponds to scientific modes of inquiry and the limited range of topics that fall under its umbrella, that must be recognized and incorporated into the general understanding of its long-term promise.

In the era of globalization and with the emergence of autism spectrum disorder as a global concern, the landscape of autism research has expanded to encompass much of the world. Here, we seek to provide an overview of the world of autism research, by documenting collaboration underlying the International Meeting for Autism Research (IMFAR), the pre-eminent annual scientific meeting devoted to the presentation of the latest autism research. We analyzed published abstracts presented at IMFAR meetings, between 2008 and 2013, to determine patterns of collaboration. We described collaboration networks on the individual, institutional, and international levels, and visually depicted these results on spatial network maps. Consistent with findings from other scientific disciplines, we found that collaboration is correlated with research productivity. Collaborative hotspots of autism research throughout the years were clustered on the East and West coasts of the U.S., Canada, and northern Europe. In years when conferences were held outside of North America, the proportion of abstracts from Europe and Asia increased. While IMFAR has traditionally been dominated by a large North American presence, greater global representation may be attained by shifting meeting locations to other regions of the world.

We explore classifying scientific disciplines including their temporal features by focusing on their collaboration structures over time. Bibliometric data for Slovenian researchers registered at the Slovenian Research Agency were used. These data were obtained from the Slovenian National Current Research Information System. We applied a recently developed hierarchical clustering procedure for symbolic data to the coauthorship structure of scientific disciplines. To track temporal changes, we divided data for the period 1986‐2010 into five 5-year time periods. The clusters of disciplines for the Slovene science system revealed 5 clusters of scientific disciplines that, in large measure, correspond with the official national classification of sciences. However, there were also some significant differences pointing to the need for a dynamic classification system of sciences to better characterize them. Implications stemming from these results, especially with regard to classifying scientific disciplines, understanding the collaborative structure of science, and research and development policies, are discussed.

Irregular migration can be broadly defined as people’s mobility that is unauthorised or forced, and this book expands on the existing migration-security nexus by moving away from the traditional state security lens, and instead, shifting ...

PROBLEM: After the first and second international conferences on reproductive immunology held by Dr. DaJin Li in Shanghai the related investigators all over the world hope to get together to share their latest findings with each other. METHOD OF STUDY: Drs. DaJin Li and MeiRong Du sponsored and organized the third international conference on reproductive immunology at the Obstetrics and Gynecology Hospital affiliated with Fudan University Shanghai China in the autumn of 2013. RESULTS: This congress brought together more than 100 International and National investigators representing a wide range of scientific disciplines. All the investigators actively work on reproductive immunology using human or large and small animal models. A range of reproductive immunological topics including the maternal-fetal immune regulation reproductive tract mucosal immunology immunocontraception and pregnancy complications were highlighted and discussed in this conference. CONCLUSION: This conference supplied a good platform for the international reproductive immunologists to exchange their latest study progression and discuss the development direction of reproductive immunology in the near future. (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

It has been about 25 years since a landmark cloning study identified the molecular identity of the first of 18 different genes that encode the ionotropic glutamate receptor (iGluR) family (Hollmann et al. 1989). Since that time, we have witnessed major advances in our understanding of the biology of iGluRs. Breakthroughs in genetics provided our first insights into the many roles iGluRs fulfil in behaviour and disease (Mulle et al. 1998), with advances in biochemistry identifying the myriad of protein partners that shuttle iGluRs into and out of synapses (Nicoll et al. 2006; Sheng & Kim, 2011). The last decade has been dominated by structural biology, which has offered an unprecedented glimpse into the working life of the iGluR at atomic resolution (Gouaux, 2004; Mayer & Armstrong, 2004). Each great advance has drawn more and more distinct scientific disciplines into the iGluR field, making it a challenge to keep up with the latest technological developments and biological advances.

Subject repositories are open web collections of working papers or manuscript copies of published scholarly articles, specific to particular scientific disciplines. The first repositories emerged in the early 1990s, and in some fields of science they have become an important channel for the dissemination of research results. With quite strict inclusion criteria, 56 subject repositories were identified from a much larger number indexed in 2 repository indices. A closer study of these demonstrated a huge variety in sizes, organizational models, functions, and topics. When they first started to emerge, subject repositories catered to a strong market demand, but the later development of Internet search engines, the rapid growth of institutional repositories, and the tightening of journal publisher open access policies seems to be slowing their growth.

Pipecolic acid naturally occurs in microorganisms, plants, and animals, where it plays many roles, including the interactions between these organisms, and is a key constituent of many natural and synthetic bioactive molecules. This article provides a review of current knowledge on the natural occurrence of pipecolic acid and the known and potential significance of its L- and D-enantiomers in different scientific disciplines. Knowledge gaps with perspectives for future research identified within this article include the roles of the L- versus the D-enantiomer of pipecolic acid in plant resistance, nutrient acquisition, and decontamination of polluted soils, as well as rhizosphere ecology and medical issues.

Species introductions of anthropogenic origins are a major aspect of rapid ecological change globally. Research on biological invasions has generated a large literature on many different aspects of this phenomenon. Here, we describe and categorize some aspects of this literature, to better understand what has been studied and what we know, mapping well-studied areas and important gaps. To do so, we employ the techniques of systematic reviewing widely adopted in other scientific disciplines, to further the use of approaches in reviewing the literature that are as scientific, repeatable, and transparent as those employed in a primary study. We identified 2398 relevant studies in a field synopsis of the biological invasions literature. A majority of these studies (58%) were concerned with hypotheses for causes of biological invasions, while studies on impacts of invasions were the next most common (32% of the publications). We examined 1537 papers in greater detail in a systematic review. Superior competitive abilities of invaders, environmental disturbance, and invaded community species richness were the most common hypotheses examined. Most studies examined only a single hypothesis. Almost half of the papers were field observational studies. Studies of terrestrial invasions dominate the literature, with most of these concerning plant invasions. The focus of the literature overall is uneven, with important gaps in areas of theoretical and practical importance.

Lignin is an abundant biopolymer with a high carbon content and high aromaticity. Despite its potential as a raw material for the fuel and chemical industries, lignin remains the most poorly utilised of the lignocellulosic biopolymers. Effective valorisation of lignin requires careful fine-tuning of multiple "upstream" (i.e., lignin bioengineering, lignin isolation and "early-stage catalytic conversion of lignin") and "downstream" (i.e., lignin depolymerisation and upgrading) process stages, demanding input and understanding from a broad array of scientific disciplines. This review provides a "beginning-to-end" analysis of the recent advances reported in lignin valorisation. Particular emphasis is placed on the improved understanding of lignin's biosynthesis and structure, differences in structure and chemical bonding between native and technical lignins, emerging catalytic valorisation strategies, and the relationships between lignin structure and catalyst performance.

© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.Lignin is an abundant biopolymer with a high carbon content and high aromaticity. Despite its potential as a raw material for the fuel and chemical industries, lignin remains the most poorly utilised of the lignocellulosic biopolymers. Effective valorisation of lignin requires careful fine-tuning of multiple “upstream” (i.e., lignin bioengineering, lignin isolation and “early-stage catalytic conversion of lignin”) and “downstream” (i.e., lignin depolymerisation and upgrading) process stages, demanding input and understanding from a broad array of scientific disciplines. This review provides a “beginning-to-end” analysis of the recent advances reported in lignin valorisation. Particular emphasis is placed on the improved understanding of lignins biosynthesis and structure, differences in structure and chemical bonding between native and technical lignins, emerging catalytic valorisation strategies, and the relationships between lignin structure and catalyst performance.

WOS: 000374787900010, In this study, different methods to teach and visualize the motion of a single degree of freedom system for engineering undergraduate and graduate students and professionals are described. The examined concepts include the P-Delta effect in a single degree of freedom system. First, the theoretical background is given. Then, an experimental setup was used to verify the theory. The experimental setup consists of a steel saw with a height, h and stiffness k. An additional mass is put on top of steel saw. A new simple method to find period of a Single Degree of Freedom model is introduced. Using an acoustic method in a new way, period of the oscillating saw is determined. By digitally processing the captured acoustic waves, the period characteristics of the system are calculated. A simulation tool is also developed using Mathematica (R) software. The simulation provided the users a way to visualize the motion of the system in time along with simple animations. These simple experimental setup and simulation tool provided convenient and useful approaches to demonstrate the concepts including the P-Delta effect in a single degree of freedom system. (C) 2016 Wiley Periodicals, Inc.

The article outlines the career of the renowned South African scientist Phillip Vallentine Tobias. While he made substantial contributions to a number of scientific disciplines, Tobias spent most of his career teaching anatomy at his alma mater, University of the Witwatersrand, Johannesburg, and saw himself primarily as an anatomist. The first part of this article presents Tobias' major contributions to science and demonstrates that his profound knowledge of anatomy was the basis of many of his groundbreaking research accomplishments. The second part of the article focuses on Tobias' career in anatomy and his significant contribution to anatomy teaching and administration, particularly in establishing and organizing the Anatomical Society of Southern Africa. The article also demonstrates how Tobias' academic career was constrained by the oppressive system of apartheid South Africa and how social engagement was an integral part of his intellectual activities.

The effective separation of X- and Y-bearing chromosome spermatozoa has been a topic of major attraction to a number of scientific disciplines. Approaches have typically been based upon either the kinetic or the physical characteristics of spermatozoa. Much of the information available to date has either suggested conflicting evidence between different approaches or a lack of repeatability, while other robust and reproducible techniques require expensive equipment and are being questioned with relation to their safety in clinical applications. This study describes a safe and efficient method for the successful enrichment of the Y-bearing chromosome spermatozoa cells from their X counterparts in the human male using a simple approach based on centrifugation. Five donor candidates with normal semen profiles and proven fertility were recruited. In total, 20 semen specimens were processed using conventional swim-up. During each attempt, half of the swim-up product was subjected to the enrichment technique and the other half served as control. Parameters important for successfully skewing sex ratios included the relative centrifugal force, the duration of centrifugal separation and the number of centrifugation rounds. Assessment of samples following the separation technique was effected by a three-colour-labelled fluorescent in situ hybridization. More than 1000 spermatozoa for each donor specimen were assessed for the presence of an X or Y chromosome. The enrichment technique produced a significantly higher (p < 0.001) overall frequency of 85.5% for the Y-bearing chromosome spermatozoa in the experimental group (3606 X-bearing/21, 209 Y-bearing) compared with a frequency of 50.1% in the control group (11,801 X-bearing/11,269 Y-bearing), where there was no statistically significant difference in the number of either X- or Y-chromosome-bearing spermatozoa. In conclusion, successful skewing of human Y-bearing chromosome spermatozoa can be reproducibly achieved by the use of simple swim-up followed by a meticulous centrifugation protocol.

Laboratories have been a cornerstone in teaching and learning across multiple scientific disciplines for more than 100 years. At the collegiate level, science laboratories and their corresponding lectures are often offered as separate courses, and students may not be required to concurrently enroll in both. In this study, we provide evidence that enrolling in an introductory laboratory concurrently with the corresponding lecture course enhances learning gains and retention in comparison to students who enroll in the lecture alone. We examined the impact of concurrent versus nonconcurrent enrollment on 9,438 students' withdrawal rates from and final grades in the general chemistry lecture at the University of Michigan at Ann Arbor using multiple linear and binary logistic regression analyses, respectively, at a significance level of 0.05. We found that concurrent enrollment in the lecture and laboratory positively impacts (1) the odds of retention in the lecture by 2.2 times on average and (2) final lecture grades by up to 0.19 grade points on a 4.0 scale for the lowest-scoring students according to university-level mathematics and chemistry placement exam scores. These data provide important results for consideration by curriculum advisors and course planners at universities that do not require concurrent enrollment in general chemistry as well as other science courses. In the face of current budget cuts that threaten to shorten or eliminate laboratory experiences altogether at multiple educational levels, this study demonstrates the value of laboratories in promoting science learning and retention. © 2012 Wiley Periodicals, Inc. J Res Sci Teach 49: 659–682, 2012

Marie Sklodowska-Curie, the first woman to win a Nobel Prize and the only person to be awarded the Nobel Prize twice in different scientific disciplines, is an inspiring figure. She discovered two new elements, polonium and radium, and was appointed as the first female professor at the University of Paris, when in most countries women did not yet have the right to vote. She serves as a role model for scholarly and humanitarian endeavors through what she attained in science, and through the hardships she had to overcome and the gender discrimination barriers faced by women scientists of that period, which she had to break. This article is a tribute to Marie Sklodowska-Curie's achievements.

Converging lines of evidence from varied scientific disciplines suggest that cutaneous melanomas comprise biologically distinct subtypes that arise through multiple causal pathways. Understanding the respective relationships of each subtype with etiologic factors such as UV radiation and constitutional factors is the first necessary step toward developing refined prevention strategies for the specific forms of melanoma. Furthermore, classifying this disease precisely into biologically distinct subtypes is the key to developing mechanism- based treatments, as highlighted by recent discoveries. In this review, we outline the historical developments that underpin our understanding of melanoma heterogeneity, and we do this from the perspectives of clinical presentation, histopathology, epidemiology, molecular genetics, and developmental biology. We integrate the evidence from these separate trajectories to catalog the emerging major categories of melanomas and conclude with important unanswered questions relating to the development of melanoma and its cells of origin.

A significant amount of science coverage can be found nowadays in the mass media and is the main source of information about science for many. Accordingly, the relation between science and the media has been intensively analyzed within the social scientific community. It is difficult to keep track of this research, however, as a flurry of studies has been published on the issue. This article provides such an overview. First, it lays out the main theoretical models of science communication, that is, the ‘public understanding of science’ and the ‘mediatization’ model. Second, it describes existing empirical research. In this section, it demonstrates how science’s agenda-building has improved, how science journalists working routines are described, how different scientific disciplines are presented in the mass media and what effects these media representations (might) have on the audience. Third, the article points out future fields of research.

We investigated 24 web-based data repositories with “controlled collections” to determine why and how repositories control access to and use of data. We selected our sample of data repositories from across scholarly and scientific disciplines in order to investigate differences between fields. Using content analysis and surveys, we collected data about current repository policies and practices and underlying motivations for controlling data access and use. Looking across all disciplines, we found no overarching reason for restricting access to data, but “avoiding misuse” was listed most frequently. Ensuring attribution was the dominant reason for controlling use of data. Observed between-field findings are tentative given the small number of repositories in some fields that met study criteria; however, our data do suggest some interesting differences. We also found cross-disciplinary patterns regarding methods for controlling access to and use of data. Better understanding of and attention to access and use control interests may allow repositories to attract more data depositors and ultimately increase the amount of data that can be shared.

The intuitive description of small and large molecules using graphs has led to an increasing interest in the application of graph concepts for describing, analyzing, and comparing small molecules as well as proteins. Graph theory is a well-studied field and many applications are present in various scientific disciplines. Recent literature describes a number of successful applications to biological problems. One of the most applied concepts aims at finding a maximal common subgraph (MCS) isomorphism between two graphs. We review exact MCS algorithms, especially designed for graphs obtained from small and large molecules, and give an overview of their successful applications. © 2011 John Wiley & Sons, Ltd. WIREs Comput Mol Sci 2011 1 68–79 DOI: 10.1002/wcms.5

Based on analyses of the share of documents of structural geology and tectonics in the GeoRef system over 100 years in the last century, and the historical change of international (31 years) and domestic (16 years) document counts of various topics in structural geology and tectonics, the position of structural geology and tectonics in the geosciences is evaluated and the major advaces in fields of plate tectonics, continental dynamics and global dynamics are reviewed. Our attention mainly focuses on the advances in studies of structural analysis, deformation mechanisms and rheology of rocks, contractional tectonics and late- and post-orogenic extensional collapse in orogens, large-scale strike-slip faults and indentation-extrusion tectonics, active tectonics and natural hazards. The relationships of structural geology and tectonics with petrology and geochronology are also discussed in terms of intersection of scientific disciplines. Finally, some suggestions are proposed for the further development of structural geology and tectonics in China.