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269 results on '"Schneider, S"'

3. Intrinsic Magnetic Properties of a Highly Anisotropic Rare-Earth-Free Fe2P-Based Magnet

Author

He, Y., Adler, P., Schneider, S., Soldatov, I., Mu, Q., Borrmann, H., Schnelle, W., Schaefer, R., Rellinghaus, B., Fecher, G. H., Felser, C., He, Y., Adler, P., Schneider, S., Soldatov, I., Mu, Q., Borrmann, H., Schnelle, W., Schaefer, R., Rellinghaus, B., Fecher, G. H., and Felser, C.

Abstract

Permanent magnets are applied in many large-scale and emerging applications and are crucial components in numerous established and newly evolving technologies. Rare-earth magnets exhibit excellent hard magnetic properties; however, their applications are limited by the price and supply risk of the strategic rare-earth elements. Therefore, there is an increasing demand for inexpensive magnets without strategic elements. Here, the authors report the intrinsic highly-anisotropic magnetic properties of Co and Si co-doped single crystals (Fe1−yCoy)2P1−xSix (y ≈ 0.09). Co increases Curie temperature TC; Si doping decreases magnetocrystalline anisotropy K1 and also increases TC significantly because of the enhanced interlayer interaction. The maximum room temperature magnetocrystalline anisotropy K1 = 1.09 MJ m−3 is achieved for x = 0.22, with saturation magnetization µ0Ms = 0.96 T and TC = 506 K. The theoretical maximum energy product is one of the largest for any magnet without a rare earth or Pt. Besides its promising intrinsic magnetic properties and absence of any strategic elements, other advantages are phase stability at high temperatures and excellent corrosion resistance, which make this material most promising for permanent magnetic development that will have a positive influence in industry and daily life. © 2021 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH.

Published
2022

5. DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis

Author

Beck, MA, Fischer, H, Grabner, LM, Groffics, T, Winter, M, Tangermann, S, Meischel, T, Zaussinger-Haas, B, Wagner, P, Fischer, C, Folie, C, Arand, J, Schoefer, C, Ramsahoye, B, Lagger, S, Machat, G, Eisenwort, G, Schneider, S, Podhornik, A, Kothmayer, M, Reichart, U, Gloesmann, M, Tamir, I, Mildner, M, Sheibani-Tezerji, R, Kenner, L, Petzelbauer, P, Egger, G, Sibilia, M, Ablasser, A, Seiser, C, Beck, MA, Fischer, H, Grabner, LM, Groffics, T, Winter, M, Tangermann, S, Meischel, T, Zaussinger-Haas, B, Wagner, P, Fischer, C, Folie, C, Arand, J, Schoefer, C, Ramsahoye, B, Lagger, S, Machat, G, Eisenwort, G, Schneider, S, Podhornik, A, Kothmayer, M, Reichart, U, Gloesmann, M, Tamir, I, Mildner, M, Sheibani-Tezerji, R, Kenner, L, Petzelbauer, P, Egger, G, Sibilia, M, Ablasser, A, and Seiser, C

Abstract

DNA methylation is a fundamental epigenetic modification, important across biological processes. The maintenance methyltransferase DNMT1 is essential for lineage differentiation during development, but its functions in tissue homeostasis are incompletely understood. We show that epidermis-specific DNMT1 deletion severely disrupts epidermal structure and homeostasis, initiating a massive innate immune response and infiltration of immune cells. Mechanistically, DNA hypomethylation in keratinocytes triggered transposon derepression, mitotic defects, and formation of micronuclei. DNA release into the cytosol of DNMT1-deficient keratinocytes activated signaling through cGAS and STING, thus triggering inflammation. Our findings show that disruption of a key epigenetic mark directly impacts immune and tissue homeostasis, and potentially impacts our understanding of autoinflammatory diseases and cancer immunotherapy.

Published
2021

17. Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study

Author

Kalman, JL, Papiol, S, Forstner, AJ, Heilbronner, U, Degenhardt, F, Strohmaier, J, Adli, M, Adorjan, K, Akula, N, Alda, M, Anderson-Schmidt, H, Andlauer, TFM, Anghelescu, I-G, Ardau, R, Arias, B, Arolt, V, Aubry, J-M, Backlund, L, Bartholdi, K, Bauer, M, Baune, BT, Becker, T, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Brichant-Petitjean, C, Budde, M, Cervantes, P, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Comes, AL, Cruceanu, C, Czerski, PM, Dannlowski, U, Dayer, A, Del Zompo, M, DePaulo, JR, Dietrich, DE, Etain, B, Ethofer, T, Falkai, P, Fallgatter, A, Figge, C, Flatau, L, Folkerts, H, Frisen, L, Frye, MA, Fullerton, JM, Gade, K, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Gryaznova, A, Hake, M, Hauser, J, Herms, S, Hoffmann, P, Hou, L, Jaeger, M, Jamain, S, Jimenez, E, Juckel, G, Kahn, J-P, Kassem, L, Kelsoe, J, Kittel-Schneider, S, Kliwicki, S, Klohn-Sagatholislam, F, Koller, M, Koenig, B, Konrad, C, Lackner, N, Laje, G, Landen, M, Lang, FU, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, SL, McMahon, FJ, Mitchell, PB, Mitjans, M, Mondimore, FM, Monteleone, P, Nieratschker, V, Nievergelt, CM, Novak, T, Osby, U, Pfennig, A, Potash, JB, Reich-Erkelenz, D, Reif, A, Reimer, J, Reininghaus, E, Reitt, M, Ripke, S, Rouleau, GA, Rybakowski, JK, Schalling, M, Scherk, H, Schmauss, M, Schofield, PR, Schubert, KO, Schulte, EC, Schulz, S, Senner, F, Severino, G, Shekhtman, T, Shilling, PD, Simhandl, C, Slaney, CM, Spitzer, C, Squassina, A, Stamm, T, Stegmaier, S, Stierl, S, Stopkova, P, Thiel, A, Tighe, SK, Tortorella, A, Turecki, G, Vieta, E, Veeh, J, von Hagen, M, Wigand, ME, Wiltfang, J, Witt, S, Wright, A, Zandi, PP, Zimmermann, J, Noethen, M, Rietschel, M, Schulze, TG, Kalman, JL, Papiol, S, Forstner, AJ, Heilbronner, U, Degenhardt, F, Strohmaier, J, Adli, M, Adorjan, K, Akula, N, Alda, M, Anderson-Schmidt, H, Andlauer, TFM, Anghelescu, I-G, Ardau, R, Arias, B, Arolt, V, Aubry, J-M, Backlund, L, Bartholdi, K, Bauer, M, Baune, BT, Becker, T, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Brichant-Petitjean, C, Budde, M, Cervantes, P, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Comes, AL, Cruceanu, C, Czerski, PM, Dannlowski, U, Dayer, A, Del Zompo, M, DePaulo, JR, Dietrich, DE, Etain, B, Ethofer, T, Falkai, P, Fallgatter, A, Figge, C, Flatau, L, Folkerts, H, Frisen, L, Frye, MA, Fullerton, JM, Gade, K, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Gryaznova, A, Hake, M, Hauser, J, Herms, S, Hoffmann, P, Hou, L, Jaeger, M, Jamain, S, Jimenez, E, Juckel, G, Kahn, J-P, Kassem, L, Kelsoe, J, Kittel-Schneider, S, Kliwicki, S, Klohn-Sagatholislam, F, Koller, M, Koenig, B, Konrad, C, Lackner, N, Laje, G, Landen, M, Lang, FU, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, SL, McMahon, FJ, Mitchell, PB, Mitjans, M, Mondimore, FM, Monteleone, P, Nieratschker, V, Nievergelt, CM, Novak, T, Osby, U, Pfennig, A, Potash, JB, Reich-Erkelenz, D, Reif, A, Reimer, J, Reininghaus, E, Reitt, M, Ripke, S, Rouleau, GA, Rybakowski, JK, Schalling, M, Scherk, H, Schmauss, M, Schofield, PR, Schubert, KO, Schulte, EC, Schulz, S, Senner, F, Severino, G, Shekhtman, T, Shilling, PD, Simhandl, C, Slaney, CM, Spitzer, C, Squassina, A, Stamm, T, Stegmaier, S, Stierl, S, Stopkova, P, Thiel, A, Tighe, SK, Tortorella, A, Turecki, G, Vieta, E, Veeh, J, von Hagen, M, Wigand, ME, Wiltfang, J, Witt, S, Wright, A, Zandi, PP, Zimmermann, J, Noethen, M, Rietschel, M, and Schulze, TG

Abstract

OBJECTIVES: Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients. METHODS: A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [>18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models. RESULTS: BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment. CONCLUSIONS: The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.

Published
2019

21. Cover Image

Author

Mathias, C. B., primary, Schramm, C. M., additional, Guernsey, L. A., additional, Wu, C. A., additional, Polukort, S. H., additional, Rovatti, J., additional, Ser-Dolansky, J., additional, Secor, E., additional, Schneider, S. S., additional, Thrall, R. S., additional, and Aguila, H. L., additional

Published
2017
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23. Brain iron accumulation in Wilson disease: apost mortem7 Tesla MRI - histopathological study

Author

Dusek, P., primary, Bahn, E., additional, Litwin, T., additional, Jabłonka-Salach, K., additional, Łuciuk, A., additional, Huelnhagen, T., additional, Madai, V. I., additional, Dieringer, M. A., additional, Bulska, E., additional, Knauth, M., additional, Niendorf, T., additional, Sobesky, J., additional, Paul, F., additional, Schneider, S. A., additional, Czlonkowska, A., additional, Brück, W., additional, Wegner, C., additional, and Wuerfel, J., additional

Published
2016
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27. Angiographic and clinical outcomes of patients treated with everolimus‐eluting bioresorbable stents in routine clinical practice: Results of the ISAR‐ABSORB registry

Author

Hoppmann, P., primary, Kufner, S., additional, Cassese, S., additional, Wiebe, J., additional, Schneider, S., additional, Pinieck, S., additional, Scheler, L., additional, Bernlochner, I., additional, Joner, M., additional, Schunkert, H., additional, Laugwitz, K‐L., additional, Kastrati, A., additional, and Byrne, RA, additional

Published
2015
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28. ?Apraxia of lid opening,? a focal eyelid dystonia: Clinical study of 32 patients

Author

Krack, Paul, Marion, M H, Kaps, M, Warnke, P, Schneider, S, and Traupe, H

Subjects
Adult, Botulinum Toxins/administration & dosage, Male, medicine.medical_specialty, Botulinum Toxins, Apraxias, Blepharospasm, Dystonia/diagnosis/drug therapy/etiology, Injections, Intramuscular, Apraxia, Progressive supranuclear palsy, Neurologic Examination/drug effects, Eyelid Diseases/diagnosis/drug therapy/etiology, medicine, Humans, Aged, Neurologic Examination, Aged, 80 and over, Dystonia, Dose-Response Relationship, Drug, Orbicularis oculi muscle, business.industry, Parkinson Disease, Middle Aged, medicine.disease, Botulinum toxin, eye diseases, Trihexyphenidyl, Parkinson Disease/diagnosis/drug therapy/etiology, Surgery, medicine.anatomical_structure, Palpebral fissure, Neurology, Blepharospasm/diagnosis/drug therapy/etiology, Anesthesia, Eyelid Diseases, Trihexyphenidyl/administration & dosage, Drug Therapy, Combination, Female, Neurology (clinical), Eyelid, medicine.symptom, business, Apraxias/diagnosis/drug therapy/etiology, medicine.drug
Abstract

We have seen 32 patients with "apraxia of lid opening" (ALO) in the following clinical settings: as an isolated condition (3 patients), idiopathic blepharospasm (BSP, 20 patients, including 4 familial cases), progressive supranuclear palsy (PSP, 7 patients), and dystonic parkinsonian syndrome (2 patients). Twenty-nine patients treated with botulinum toxin into the orbicularis oculi muscle were rated before and after treatment and 83% of the patients improved on a clinical scale. Best results were obtained with injections directed toward the junction of the preseptal and pretarsal parts of the palpebral orbicularis oculi. Several patients also improved on anticholinergic drugs. Besides medical treatment, lid crutches, in conjunction with botulinum toxin injections, were useful in some patients. ALO is not a true apraxia; it constitutes an eyelid dystonia as shown by its clinical and electrophysiological features as well as pharmacological reactions and is encountered in a clinical spectrum ranging from an isolated form to predominant BSP. It was an important cause of treatment failures in botulinum toxin-treated BSP but by modifying our injection strategy and by adding anticholinergic drugs and also lid crutches, we obtained a good functional benefit.

Published
1994

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