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A fear of being rejected can cause perceptions of more insecurity and stress in close relationships. Healthy individuals activate the dorsal anterior cingulate cortex (dACC) when experiencing social rejection, while those who are vulnerable to depression deactivate the dACC presumably to downregulate salience of rejection cues and minimize distress. Schizotypal individuals, characterized by unusual perceptual experiences and/or odd beliefs, are more rejection sensitive than normal. We tested the hypothesis, for the first time, that individuals with high schizotypy also have an altered dACC response to rejection stimuli. Twenty-six healthy individuals, 14 with low schizotypy (LS) and 12 with high schizotypy (HS), viewed depictions of rejection and acceptance and neutral scenes while undergoing functional MRI. Activation maps in LS and HS groups during each image type were compared using SPM5, and their relation to participant mood and subjective ratings of the images was examined. During rejection relative to neutral scenes, LS activated and HS deactivated the bilateral dACC, right superior frontal gyrus, and left ventral prefrontal cortex. Across both groups, a temporo-occipito-parieto-cerebellar network was active during rejection, and a left fronto-parietal network during acceptance, relative to neutral scenes, and the bilateral lingual gyrus during rejection relative to acceptance scenes. Our finding of dACC-dorso-ventral PFC activation in LS, but deactivation in HS individuals when perceiving social rejection scenes suggests that HS individuals attach less salience to and distance themselves from such stimuli. This may enable them to cope with their higher-than-normal sensitivity to rejection., (Copyright © 2011 Wiley Periodicals, Inc.)

The present study compared negative priming performance in a non-clinical sample of individuals based on their schizotypal personality scale (STA) scores. There were 13 High STA and 19 Low STA individuals. High, but not Low, STA individuals displayed deficient negative priming, replicating previous findings. Converging evidence for this claim was observed in the correlation between negative priming and STA score, r = -.64, p < .01, supporting the notion that individuals with high STA scores exhibit an inability to adequately inhibit irrelevant information. Both groups did not differ on a simple reaction time control task, ruling out the possibility that observed negative priming differences across groups were the result of a simple motor reaction time difference.