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Your search keyword '"Sato, Kazunori"' showing total 46 results
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46 results on '"Sato, Kazunori"'

4. Probing the Entropic Effect in Molecular Noncovalent Interactions between Resin-Bound Polybrominated Arenes and Small Substrates

Author

Yamamoto, Masanori, Obara, Miyuki, Ochi, Keisuke, Yamamoto, Atsushi, Takenaka, Katsuhiko, Tanaka, Tsunehiro, and Sato, Kazunori

Subjects
noncovalent interactions, adsorption, liquid chromatography, solid-phase extraction, entropy
Abstract

The associative interaction between resin‐bound polybrominated arenes and small molecules was analyzed by using various spectroscopic techniques as well as a synthetic molecular model to establish the thermodynamics. The binding in acetonitrile was three orders of magnitude stronger than that in methanol, partly owing to the tertiary conformational gating of the resin that controls the entropic terms. By using the entropic superiority, the associative binding of up to 3×104 m−1 is achieved with the non‐biological system. A modified Hill plot for the quantitative analysis of bindings was also devised, which enabled the interactions at the molecular level to be elucidated.

Published
2018

6. Probing the Entropic Effect in Molecular Noncovalent Interactions between Resin-Bound Polybrominated Arenes and Small Substrates

Author

70201621, Yamamoto, Masanori, Obara, Miyuki, Ochi, Keisuke, Yamamoto, Atsushi, Takenaka, Katsuhiko, Tanaka, Tsunehiro, Sato, Kazunori, 70201621, Yamamoto, Masanori, Obara, Miyuki, Ochi, Keisuke, Yamamoto, Atsushi, Takenaka, Katsuhiko, Tanaka, Tsunehiro, and Sato, Kazunori

Abstract

The associative interaction between resin‐bound polybrominated arenes and small molecules was analyzed by using various spectroscopic techniques as well as a synthetic molecular model to establish the thermodynamics. The binding in acetonitrile was three orders of magnitude stronger than that in methanol, partly owing to the tertiary conformational gating of the resin that controls the entropic terms. By using the entropic superiority, the associative binding of up to 3×104 m−1 is achieved with the non‐biological system. A modified Hill plot for the quantitative analysis of bindings was also devised, which enabled the interactions at the molecular level to be elucidated.

Published
2018

10. Neuromyelitis optica spectrum disorders accompanying subarachnoid hemorrhage and reversible white matter lesions

Author

Shirai, Shinichi, Mito, Yasunori, Nojo, Tatsuru, Yaguchi, Hiroaki, Takahashi, Toshiyuki, Sato, Kazunori, 1000060399920, Hirotani, Makoto, Kano, Takahiro, 1000060372273, Yabe, Ichiro, 1000080281806, Sasaki, Hidenao, Shirai, Shinichi, Mito, Yasunori, Nojo, Tatsuru, Yaguchi, Hiroaki, Takahashi, Toshiyuki, Sato, Kazunori, 1000060399920, Hirotani, Makoto, Kano, Takahiro, 1000060372273, Yabe, Ichiro, 1000080281806, and Sasaki, Hidenao

Abstract

A 48-year-old man was admitted to Tomakomai City Hospital, Tomakomai, Japan, because of intractable hiccups and nausea, and orthostatic hypotension. Brain magnetic resonance imaging findings showed a dorsal medullary lesion. Respiratory failure occurred, and he underwent tracheotomy and mechanical ventilation when magnetic resonance imaging showed subarachnoid hemorrhage in addition to enlarged medullary lesions. Serum anti-aquaporin-4 antibody was positive and the cerebrospinal fluid was bloody. We diagnosed meuromyelitis optica spectrum disorders complicating subarachnoid hemorrhage. He was treated with a steroid. Although extensive white matter lesions occurred transiently, the patient was discharged from the hospital when he became able to walk with the use of the walker on the 52nd day. We suggest that the subarachnoid hemorrhage and transient white matter lesions were associated with vascular damage associated with the meuromyelitis optica spectrum disorders.

Published
2014

28. Both Global Gray Matter Volume and Regional Gray Matter Volume Negatively Correlate with Lifetime Alcohol Intake in Non–Alcohol‐Dependent Japanese Men: A Volumetric Analysis and a Voxel‐Based Morphometry

Author

Taki, Yasuyuki, primary, Kinomura, Shigeo, additional, Sato, Kazunori, additional, Goto, Ryoi, additional, Inoue, Kentaro, additional, Okada, Ken, additional, Ono, Shuichi, additional, Kawashima, Ryuta, additional, and Fukuda, Hiroshi, additional

Published
2006
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37. A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (Nω-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

Author

Tada, Masao, primary, Iwata, Ren, additional, Sugiyama, Hiroshi, additional, Sato, Kazunori, additional, Pascali, Claudio, additional, Fukuda, Hiroshi, additional, Kubota, Kazuo, additional, Kubota, Roko, additional, Takahashi, Hiromu, additional, Wakui, Akira, additional, Abe, Yoshinao, additional, Fujiwara, Takehiko, additional, Sato, Tachio, additional, and Ido, Tatsuo, additional

Published
1993
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38. A concise synthesis of [carbonyl‐11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin

Author

Tada, Masao, primary, Oikawa, Atsushi, additional, Iwata, Ren, additional, Sato, Kazunori, additional, Sugiyama, Hiroshi, additional, Takahashi, Hiromu, additional, Wakui, Akira, additional, Fukuda, Hiroshi, additional, Kubota, Kazuo, additional, Abe, Yoshinao, additional, Yamaguchi, Tatsuo, additional, Fujiwara, Takehiko, additional, Sato, Tachio, additional, and Ido, Tatsuo, additional

Published
1991
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39. An efficient synthesis of 2- [ carbonyl- 11C]acetamido-2-deoxy-D-glucopyranose (N-[carbonyl-11C]acetyl-D-glucosamine)

Author

Tada, Masao, primary, Oikawa, Atsushi, additional, Iwata, Ren, additional, Sato, Kazunori, additional, Sugiyama, Hiroshi, additional, Kubota, Kazuo, additional, Ishiwata, Kiichi, additional, Takahashi, Hiromu, additional, Wakui, Akira, additional, Abe, Yoshinao, additional, Yamaguchi, Tatsuo, additional, Fujiwara, Takehiko, additional, Sato, Tachio, additional, and Ido, Tatsuo, additional

Published
1991
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40. A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

Author

Tada, Masao, primary, Oikawa, Atsushi, additional, Iwata, Ren, additional, Sato, Kazunori, additional, Kubota, Kazuo, additional, Fujiwara, Takehiko, additional, Sugiyama, Hiroshi, additional, Abe, Yoshinao, additional, Sato, Tachio, additional, Matsuzawa, Taiju, additional, Takahashi, Hiromu, additional, Wakui, Akira, additional, and Ido, Tatsuo, additional

Published
1990
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43. A longitudinal study of the relationship between personality traits and the annual rate of volume changes in regional gray matter in healthy adults.

Author

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, and Fukuda H

Subjects
Adult, Aged, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Personality Inventory, Regression Analysis, Sex Factors, Time Factors, Young Adult, Brain anatomy & histology, Brain physiology, Brain Mapping, Personality physiology
Abstract

To investigate whether personality traits affect the rate of decline of gray matter volume, we analyzed the relationships between personality traits and the annual rate of changes of gray matter volume in 274 healthy community dwelling subjects with a large age range by applying a longitudinal design over 6 years, using brain magnetic resonance images (MRI) and the Revised NEO Personality Inventory (NEO-PI-R) at baseline. Brain MRI data were processed using voxel-based morphometry with a custom template by applying the DARTEL diffeomorphic registration tool. For each subject, we used NEO-PI-R to evaluate the five major personality traits, including neuroticism, extraversion, openness, agreeableness, and conscientiousness. The results show that the annual rate of change in regional gray matter volume in the right inferior parietal lobule was correlated significantly and negatively with a personality of openness, which is known to be related to intellect, intellectual curiosity, and creativity adjusting for age, gender, and intracranial volume. This result indicates that subjects with a personality trait of less openness have an accelerated loss of gray matter volume in the right inferior parietal lobule, compared with subjects with a personality trait of more openness. Because the right inferior parietal lobule is involved in higher cognitive function such as working memory and creativity, a personality trait of openness is thought to be important for preserving gray matter volume and cognitive function of the right inferior parietal lobule in healthy adults., (Copyright © 2012 Wiley Periodicals, Inc.)

Published
2013
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44. Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects.

Author

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kakizaki M, Tsuji I, Kawashima R, and Fukuda H

Subjects
Aged, Asymptomatic Diseases, Blood Pressure, Cross-Sectional Studies, Disease Progression, Female, Humans, Inflammation, Intracranial Arteriosclerosis pathology, Japan, Lipids blood, Male, Organ Size, Reference Values, Temporal Lobe pathology, Brain anatomy & histology, C-Reactive Protein analysis, Magnetic Resonance Imaging, Neuroimaging
Abstract

Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationship between hsCRP levels and brain regional gray matter volume using brain magnetic resonance imaging (MRI) data from 109 community-dwelling healthy elderly subjects. Brain MRIs were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra (DARTEL) procedure. We found a significant negative correlation between regional gray matter volume of the posterior and lateral aspects of the left temporal cortex and hsCRP level after adjusting for age, gender, and intracranial volume. Our results suggest that subjects who have mild inflammation related to arteriosclerosis have decreased regional gray matter volume in the posterior and lateral aspects of the left temporal cortex. Thus, preventing the progression of arteriosclerosis may be important for preventing a decrease in gray matter volume in healthy elderly subjects., (Copyright © 2012 Wiley Periodicals, Inc.)

Published
2013
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45. A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults.

Author

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, and Fukuda H

Subjects
Adult, Aged, Aged, 80 and over, Female, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult, Aging pathology, Brain pathology
Abstract

The aim of this study was to analyze correlations among the annual rate of gray matter volume change, age, gender, and cerebrovascular risk factors in 381 healthy community-dwelling subjects with a large age range by applying a longitudinal design over 6 years using brain magnetic resonance images (MRIs). Brain MRI data were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. The annual rate of regional gray matter volume change showed significant positive correlations with age in several regions, including the bilateral temporal pole, caudate nucleus, ventral and dorsolateral prefrontal cortices, insula, hippocampus, and temporoparietal cortex, whereas significant negative correlations with age were observed in several regions including the bilateral cingulate gyri and anterior lobe of the cerebellum. Additionally, a significant age-by-gender interaction was found for the annual rate of regional gray matter volume change in the bilateral hippocampus. No significant correlations were observed between the annual rate of regional gray matter volume change and body mass index or systolic blood pressure. A significant positive correlation between the annual rate of gray matter volume change and age indicates that the region shows not linear but accelerated gray matter loss with age. Therefore, evaluating the annual rate of the gray matter volume change with age in healthy subjects is important in understanding how gray matter volume changes with aging in each brain region and in anticipating what cognitive functions are likely to show accelerated decline with aging., (Copyright © 2012 Wiley Periodicals, Inc., a Wiley company.)

Published
2013
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46. Age-related changes in topological organization of structural brain networks in healthy individuals.

Author

Wu K, Taki Y, Sato K, Kinomura S, Goto R, Okada K, Kawashima R, He Y, Evans AC, and Fukuda H

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Young Adult, Aging pathology, Brain pathology, Neural Pathways pathology
Abstract

The aim of this study was to examine structural brain networks using regional gray matter volume, as well as to investigate changes in small-world and modular organization with normal aging. We constructed structural brain networks composed of 90 regions in young, middle, and old age groups. We randomly selected 350 healthy subjects for each group from a Japanese magnetic resonance image database. Structural brain networks in three age groups showed economical small-world properties, providing high global and local efficiency for parallel information processing at low connection cost. The small-world efficiency and node betweenness varied significantly and revealed a U- or inverted U-curve model tendency among three age groups. Results also demonstrated that structural brain networks exhibited a modular organization in which the connections between regions are much denser within modules than between them. The modular organization of structural brain networks was similar between the young and middle age groups, but quite different from the old group. In particular, the old group showed a notable decrease in the connector ratio and the intermodule connections. Combining the results of small-world efficiency, node betweenness and modular organization, we concluded that the brain network changed slightly, developing into a more distributed organization from young to middle age. The organization eventually altered greatly, shifting to a more localized organization in old age. Our findings provided quantitative insights into topological principles of structural brain networks and changes related to normal aging., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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