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The synthesis of hitherto unreported 5-amino-7-alkoxy2-methyl-2,4-aryl-1,2-dihydro-1,6-naphthyridine-8-carbonitriles (4) was accomplished by a one-pot pseudo five-component reaction using aryl methyl ketones or alkyl methyl ketones, malononitrile, and alcohols in the presence of sodium hydroxide under reflux conditions. By following an identical reaction procedure, various 5-amino-2-methyl-2,4

A hitherto unreported route for the synthesis of anthranilate esters is demonstrated using 2-nitrobenzaldehyde, malonitrile and an alcohol or amine via a metal and oxidant free multicomponent reaction (MCR) strategy. This process simultaneously installs an ester and urea or urethane functionality via CO and CN bond formations via concurrent oxidation of the aldehyde group and reduction of the nitro group involving an intramolecular redox process.

An efficient protocol has been developed for the synthesis of pyridines and 1,4-dihydropyridines based on chemoselective multicomponent reactions. Using readily available aldehydes, malononitrile and primary aliphatic amines, this procedure provides a divergent but straightforward access to a wide range of fully substituted pyridines and dihydropyridines via a primary amine based chemoselective strategy. Simple reaction procedure, good yields, mild reaction conditions, applicabilility to a wide range of substrates with the aid of chemoselectivity make this present protocol more innovative than existing ones.

3-Acetamidocoumarins are converted into 3-aminocoumarins upon treatment with sulfuric acid.

Title compounds (IV) and (VI) are synthesized using an one-pot three-component coupling between 3-aminocoumarins (I), aromatic aldehydes (III) and cyclic enol ethers (II) or (V).

The facile one-pot procedure allows the synthesis of 1,5-benzodiazepines from o-phenylenediamines, aldehydes, and β-keto esters under mild reaction conditions.

The title reaction proceeds under mild conditions with high chemoselectivity and uses easily available materials.

Title compounds such as (IV), (VI), and (VIII) are prepared via a three-component reaction of o-phenylenediamine (I), aromatic aldehydes and β-ketoesters.