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11 results on '"Sartori, Roberta"'

2. Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading‐dependent changes linked to muscle atrophy

Author

Murgia, Marta, primary, Brocca, Lorenza, additional, Monti, Elena, additional, Franchi, Martino V., additional, Zwiebel, Maximilian, additional, Steigerwald, Sophia, additional, Giacomello, Emiliana, additional, Sartori, Roberta, additional, Zampieri, Sandra, additional, Capovilla, Giovanni, additional, Gasparini, Mladen, additional, Biolo, Gianni, additional, Sandri, Marco, additional, Mann, Matthias, additional, and Narici, Marco V., additional

Published
2022
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5. Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling

Author

Solagna, Francesca, Nogara, Leonardo, Dyar, Kenneth A., Greulich, Franziska, Mir, Ashfaq A., Turk, Clara, Bock, Theresa, Geremia, Alessia, Baraldo, Martina, Sartori, Roberta, Farup, Jean, Uhlenhaut, Henriette, Vissing, Kristian, Krueger, Marcus, Blaauw, Bert, Solagna, Francesca, Nogara, Leonardo, Dyar, Kenneth A., Greulich, Franziska, Mir, Ashfaq A., Turk, Clara, Bock, Theresa, Geremia, Alessia, Baraldo, Martina, Sartori, Roberta, Farup, Jean, Uhlenhaut, Henriette, Vissing, Kristian, Krueger, Marcus, and Blaauw, Bert

Abstract

Aim Resistance exercise increases muscle mass over time. However, the early signalling events leading to muscle growth are not yet well-defined. Here, we aim to identify new signalling pathways important for muscle remodelling after exercise. Methods We performed a phosphoproteomics screen after a single bout of exercise in mice. As an exercise model we used unilateral electrical stimulation in vivo and treadmill running. We analysed muscle biopsies from human subjects to verify if our findings in murine muscle also translate to exercise in humans. Results We identified a new phosphorylation site on Myocardin-Related Transcription Factor B (MRTF-B), a co-activator of serum response factor (SRF). Phosphorylation of MRTF-B is required for its nuclear translocation after exercise and is accompanied by the transcription of the SRF target gene Fos. In addition, high-intensity exercise also remodels chromatin at specific SRF target gene loci through the phosphorylation of histone 3 on serine 10 in myonuclei of both mice and humans. Ablation of the MAP kinase member MSK1/2 is sufficient to prevent this histone phosphorylation, reduce induction of SRF-target genes, and prevent increases in protein synthesis after exercise. Conclusion Our results identify a new exercise signalling fingerprint in vivo, instrumental for exercise-induced protein synthesis and potentially muscle growth.

Published
2020

6. Exercise‐dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF‐SRF signalling

Author

Solagna, Francesca, primary, Nogara, Leonardo, additional, Dyar, Kenneth A., additional, Greulich, Franziska, additional, Mir, Ashfaq A., additional, Türk, Clara, additional, Bock, Theresa, additional, Geremia, Alessia, additional, Baraldo, Martina, additional, Sartori, Roberta, additional, Farup, Jean, additional, Uhlenhaut, Henriette, additional, Vissing, Kristian, additional, Krüger, Marcus, additional, and Blaauw, Bert, additional

Published
2020
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7. The ERG1 Potassium Channel is Abundant in Cachectic Human Skeletal Muscle

Author

Pond, Amber Lynn, primary, Zampieri, Sandra, additional, Sandri, Marco, additional, Cheatwood, Joseph, additional, Kohli, Punit, additional, Balaraman, Rajesh, additional, Anderson, Luke Brian, additional, Latour, Chase Doyne, additional, Hockerman, Gregory H., additional, Kern, Helmut, additional, Sartori, Roberta, additional, Merigiano, Stefano, additional, Da Dalt, G, additional, Davie, Judy K., additional, and Carraro, Ugo, additional

Published
2020
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8. Abstracts of the 3rd International Conference on Cancer Cachexia, September 23-25, 2016 in Washington, DC, USA

Author

Claudio Fenizia, Sperti Cosimo, Sartori Roberta, Raffaella Fittipaldi, Zare Hossein, Giuseppina Caretti, Marco Segatto, Merigliano Stefano, Filippakopoulos Panagis, and Sartorelli Vittorio

Subjects
0303 health sciences, BRD4, business.industry, Skeletal muscle, Cancer cachexia, medicine.disease, Cachexia, Blockade, Abstracts, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Physiology (medical), Cancer research, medicine, Orthopedics and Sports Medicine, business, 030304 developmental biology
Published
2017

10. Mechano‐signalling pathways in an experimental intensive critical illness myopathy model

Author

Corpeno Kalamgi, Rebeca, primary, Salah, Heba, additional, Gastaldello, Stefano, additional, Martinez‐Redondo, Vicente, additional, Ruas, Jorge L., additional, Fury, Wen, additional, Bai, Yu, additional, Gromada, Jesper, additional, Sartori, Roberta, additional, Guttridge, Denis C., additional, Sandri, Marco, additional, and Larsson, Lars, additional

Published
2016
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