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4. Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma.

Author

Tanabe S, Nakadai T, Furuoka H, Oomachi T, Kobayashi Y, Omata Y, Koyama T, Hondo E, Uzuka Y, Sarashina T, Ducusin RJ, Shida T, and Dorf ME

Subjects
Adenocarcinoma metabolism, Adenocarcinoma pathology, Animals, Base Sequence, Carcinoma, Ductal, Breast metabolism, Carcinoma, Ductal, Breast pathology, Carcinoma, Ductal, Breast veterinary, Cat Diseases pathology, Cats, Female, In Situ Hybridization veterinary, Mammary Neoplasms, Animal pathology, Molecular Sequence Data, Receptors, CXCR4 genetics, Reverse Transcriptase Polymerase Chain Reaction veterinary, Survival Analysis, Adenocarcinoma veterinary, Cat Diseases metabolism, Mammary Neoplasms, Animal metabolism, RNA, Messenger analysis, Receptors, CXCR4 biosynthesis
Abstract

The expression of mRNA of the chemokine receptor CXCR4 in 65 surgically resected mammary adenocarcinomas from cats was investigated by in situ hybridisation. No expression of the receptor's mRNA was detectable in the mammary tissue of healthy cats, but it was expressed in areas adjacent to necrosis, surrounding blood vessels and cells infiltrating the lymphatics of 47 (72.3 per cent) of the 65 samples. There was a significant relationship between lymphatic infiltration by neoplastic cells and the expression of the receptor's mRNA (P < 0.005), but there was no significant relationship between its expression and the one-year survival of the cats.

Published
2002

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