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Your search keyword '"Sarah L. DeVos"' showing total 7 results
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7 results on '"Sarah L. DeVos"'

1. Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease

Author

Georg Meisl, Yukun Zuo, Kieren Allinson, Timothy Rittman, Sarah L. DeVos, Justin S Sanchez, Catherine K. Xu, Karen E. Duff, Keith A. Johnson, James B. Rowe, Bradley T. Hyman, Tuomas Knowles, and David Klenerman

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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2. A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of GRN knockout mice

Author

Hoang Nguyen, Elizabeth Sun, Yashas Rajendra, Gerald Maxwell Cherf, Jennifer Hsiao-Nakamoto, Todd P. Logan, Joseph Duque, Anil Rana, Fen Huang, Matthew J. Simon, Kannan Gunasekaran, Pascal E. Sanchez, Junhua Wang, Mihalis Kariolis, Kirk R. Henne, Zachary Kevin Sweeney, Sofia Mosesova, Sonnet S. Davis, Bettina Van Lengerich, Do Jin Kim, Hai L. Tran, Rachel Prorok, Darren Chan, Mark S. Dennis, Kathryn M. Monroe, Yuda Zhu, Ray Low, Akhil Bhalla, Gilbert Di Paolo, Ankita Srivastava, Giuseppe Astarita, Timothy K. Earr, Joseph W. Lewcock, Roni Chau, Sarah L. DeVos, Ryan J. Watts, and Melina Lenser

Subjects
Epidemiology, Health Policy, Biology, Phenotype, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, Knockout mouse, Neurology (clinical), Geriatrics and Gerontology, Penetrant (biochemical)
Published
2020
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3. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies

Author

Diane Lucente, Stephen N. Gomperts, Chester A. Mathis, Bradley T. Hyman, Bradford C. Dickerson, Sarah L. DeVos, Marc D. Normandin, Milos D. Ikonomovic, Charles R. Vanderburg, Avery C. Meltzer, Elizabeth Bien, Michael Siao Tick Chong, Kimiko Domoto-Reilly, Keith A. Johnson, Marta Marquié, William E. Klunk, Matthew P. Frosch, Sara Makaretz, Manik L. Debnath, Nicolas V Andrea, Alejandro Antón-Fernández, John H. Growdon, Derek H. Oakley, Teresa Gomez-Isla, and Isabel Costantino

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Chemistry, Substantia nigra, Ligand (biochemistry), Entorhinal cortex, medicine.disease, Progressive supranuclear palsy, White matter, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Neurology, In vivo, Basal ganglia, medicine, Neurology (clinical), Tauopathy, 030217 neurology & neurosurgery
Abstract

Objective Recent studies have shown that positron emission tomography (PET) tracer AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV-1451 binding patterns in three autopsy-confirmed non-Alzheimer tauopathy cases. Methods We quantified in vivo retention of [F-18]-AV-1451 and performed autoradiography, [H-3]-AV-1451 binding assays, and quantitative tau measurements in postmortem brain samples from two progressive supranuclear palsy (PSP) cases and a MAPT P301L mutation carrier. They all underwent [F-18]-AV-1451 PET imaging before death. Results The three subjects exhibited [F-18]-AV-1451 in vivo retention predominantly in basal ganglia and midbrain. Neuropathological examination confirmed the PSP diagnosis in the first two subjects; the MAPT P301L mutation carrier had an atypical tauopathy characterized by grain-like tau-containing neurites in gray and white matter with heaviest burden in basal ganglia. In all three cases, autoradiography failed to show detectable [F-18]-AV-1451 binding in multiple brain regions examined, with the exception of entorhinal cortex (reflecting incidental age-related neurofibrillary tangles) and neuromelanin-containing neurons in the substantia nigra (off-target binding). The lack of a consistent significant correlation between in vivo [F-18]-AV-1541 retention and postmortem in vitro binding and tau measures in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight tau filaments. Interpretation AV-1451 may have limited utility for in vivo selective and reliable detection of tau aggregates in these non-Alzheimer tauopathies. ANN NEUROL 2017;81:117–128

Published
2017
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4. O2‐06‐01: Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice

Author

Eduardo A Maury, Samantha B. Nicholls, Rose Pitstick, Shuko Takeda, Lubna Saqran, Sarah L. DeVos, Christopher William, Bradley T. Hyman, George A. Carlson, Zhanyun Fan, Amy M. Pooler, Tara L. Spires-Jones, Molly J. Kirk, Susanne Wegmann, and Allyson D. Roe

Subjects
Genetically modified mouse, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Toxicity, Endogeny, Neurology (clinical), Geriatrics and Gerontology, Biology, Cell biology
Published
2015
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5. O3‐04‐03: Tau splicing in vivo : Application in mouse models of tauopathy confers functional and pathological changes

Author

Rebecca L. Miller, Sarah L. DeVos, Seung J. Chun, Carey S. Kebodeaux, Frank Rigo, Timothy M. Miller, Michaela Norrbom, Hana N. Dawson, C. Frank Bennett, and Kathleen M. Schoch

Subjects
Epidemiology, Health Policy, Biology, medicine.disease, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, In vivo, RNA splicing, medicine, Neurology (clinical), Tauopathy, Geriatrics and Gerontology, Pathological
Published
2015
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6. P3‐071: A unique high‐molecular‐weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer's disease patients

Author

Ana T. Trisini Lipsanopoulos, Zhanyun Fan, Shuko Takeda, Allyson D. Roe, Susanne Wegmann, Bradley T. Hyman, Matthew P. Frosch, Isabel Costantino, Sarah L. DeVos, and Caitlin Commins

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Pathology, medicine.medical_specialty, Cerebrospinal fluid, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, medicine, Neurology (clinical), Disease, Geriatrics and Gerontology
Published
2015
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7. P1‐286: Using antisense oligonucleotides to knockdown endogenous brain tau in vivo

Author

Frank C. Bennett, Carey Shaner, Dushyanth Srinivasan, Sarah L. DeVos, Giorgetti Marco, and Timothy M. Miller

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Gene knockdown, Developmental Neuroscience, Epidemiology, Chemistry, In vivo, Health Policy, Antisense oligonucleotides, Endogeny, Neurology (clinical), Geriatrics and Gerontology, Cell biology
Published
2012
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