Search

Based on the growing demand for facile and sustainable synthetic methods to structurally perfect polymers, we herein describe a significant improvement of esterification reactions capitalizing on 1,1'-carbonyldiimidazole (CDI). Cesium fluoride was shown to be an essential catalyst for these reactions to reach completion. This approach was successfully applied to the synthesis of structurally flawless and highly functional polyester dendrimers employing traditional and accelerated growth strategies. A sixth generation bis-MPA dendrimer with a molecular weight of 22.080 Da and 192 peripheral hydroxy groups was isolated in less than one day of total reaction time. Large quantities of dendrimers were obtained in high yields (90%) using simple purification steps under sustainable conditions. The fluoride-promoted esterification (FPE) via imidazolide-activated compounds is wide in scope and constitutes a potentially new approach toward functional polymers and other materials.

Die Entwicklung Kohlenmonoxid freisetzender Molekule (carbon-monoxide-releasing molecules, CORMs) als pharmazeutische Wirkstoffe stellt eine attraktive und sichere Alternative zur Verabreichung von gasformigem CO dar. Die meisten bisher entwickelten CORMs sind Carbonylkomplexe von Ubergangsmetallen. Obgleich derartige CORMs im Tierversuch bei einer Reihe von Krankheiten vielversprechende Resultate gezeitigt haben, fehlen ihnen noch die notwendigen Attribute fur eine weitergehende klinische Entwicklung. Hier werden die bis jetzt entwickelten Methoden der CORM-Selektion beschrieben. Weiterhin werden neue Erkenntnisse hinsichtlich der In-vivo-Reaktivitat von Metall-Carbonylkomplexen im Zusammenhang mit Methoden fur den CO-Nachweis in lebenden Zellen dargelegt. Es wird aufgezeigt, wie diese den Entwurf und die Synthese neuer CORMs vorantreiben.

Herein, we describe the synthesis and characterization of a sulfonate-containing N-donor ligand in its sodium salt and acid forms, Na2[(DES)MeN(CH2)2NMe(DES)]·2H2O (1) and [(DES)MeN+H(CH2)2N+HMe(DES)]·H2O (2), and its corresponding metal complexes, [{(DES)MeN(CH2)2NMe(DES)}M(H2O)2]·nH2O [M = Ni (3), Co (4), Cu (5) and Zn (6)]. Treatment of HIV-infected MT-2 cells with Ni, Co and Cu complexes inhibit virus replication up to 50–70 % both in pre- and post-infected cells as a result of dual preventive and therapeutic behaviour.