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11 results on '"Sanders, Joyce"'

1. Proteomics on malignant pleural effusions reveals ERα loss in metastatic breast cancer associates with SGK1–NDRG1 deregulation

Author

Mayayo‐Peralta, Isabel, primary, Debets, Donna O., additional, Prekovic, Stefan, additional, Schuurman, Karianne, additional, Beerthuijzen, Suzanne, additional, Almekinders, Mathilde, additional, Sanders, Joyce, additional, Moelans, Cathy B., additional, Saleiro, Sandra, additional, Wesseling, Jelle, additional, van Diest, Paul J., additional, Henrique, Rui, additional, Jerónimo, Carmen, additional, Altelaar, Maarten, additional, and Zwart, Wilbert, additional

Published
2023
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2. Prognostic impact of variant histologies in urothelial bladder cancer treated with radical cystectomy

Author

Claps, Francesco, primary, van de Kamp, Maaike W., additional, Mayr, Roman, additional, Bostrom, Peter J., additional, Shariat, Shahrokh F., additional, Hippe, Katrin, additional, Bertz, Simone, additional, Neuzillet, Yann, additional, Sanders, Joyce, additional, Otto, Wolfgang, additional, van der Heijden, Michiel S., additional, Jewett, Michael A.S., additional, Stöhr, Robert, additional, Zlotta, Alexandre R., additional, Trombetta, Carlo, additional, Eckstein, Markus, additional, Mertens, Laura S., additional, Burger, Maximilian, additional, Soorojebally, Yanish, additional, Wullich, Bernd, additional, Bartoletti, Riccardo, additional, Radvanyi, François, additional, Pavan, Nicola, additional, Sirab, Nanour, additional, Mir, M. Carmen, additional, Pouessel, Damien, additional, van der Kwast, Theo H., additional, Hartmann, Arndt, additional, Lotan, Yair, additional, Bussani, Rossana, additional, Allory, Yves, additional, and van Rhijn, Bas W.G., additional

Published
2023
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3. Effect of HIPEC according to HRD/BRCAwt genomic profile in stage III ovarian cancer: Results from the phase III OVHIPEC trial

Author

Koole, Simone N., Schouten, Philip C., Hauke, Jan, Kluin, Roel J. C., Nederlof, Petra, Richters, Lisa K., Krebsbach, Gabriele, Sikorska, Karolina, Alkemade, Maartje, Opdam, Mark, van Leeuwen, Jules H. Schagen, Schreuder, Henk W. R., Hermans, Ralph H. M., de Hingh, Ignace H. J. T., Mom, Constantijne H., Arts, Henriette J. G., van Ham, Maaike, van Dam, Peter, Vuylsteke, Peter, Sanders, Joyce, Horlings, Hugo M., van de Vijver, Koen K., Hahnen, Eric, van Driel, Willemien J., Schmutzler, Rita, Sonke, Gabe S., Linn, Sabine C., Koole, Simone N., Schouten, Philip C., Hauke, Jan, Kluin, Roel J. C., Nederlof, Petra, Richters, Lisa K., Krebsbach, Gabriele, Sikorska, Karolina, Alkemade, Maartje, Opdam, Mark, van Leeuwen, Jules H. Schagen, Schreuder, Henk W. R., Hermans, Ralph H. M., de Hingh, Ignace H. J. T., Mom, Constantijne H., Arts, Henriette J. G., van Ham, Maaike, van Dam, Peter, Vuylsteke, Peter, Sanders, Joyce, Horlings, Hugo M., van de Vijver, Koen K., Hahnen, Eric, van Driel, Willemien J., Schmutzler, Rita, Sonke, Gabe S., and Linn, Sabine C.

Abstract

The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin to interval cytoreductive surgery improves recurrence-free (RFS) and overall survival (OS) in patients with stage III ovarian cancer. Homologous recombination deficient (HRD) ovarian tumors are usually more platinum sensitive. Since hyperthermia impairs BRCA1/2 protein function, we hypothesized that HRD tumors respond best to treatment with HIPEC. We analyzed the effect of HIPEC in patients in the OVHIPEC trial, stratified by HRD status and BRCAm status. Clinical data and tissue samples were collected from patients included in the randomized, phase III OVHIPEC-1 trial. DNA copy number variation (CNV) profiles, HRD-related pathogenic mutations and BRCA1 promotor hypermethylation were determined. CNV-profiles were categorized as HRD or non-HRD, based on a previously validated algorithm-based BRCA1-like classifier. Hazard ratios (HR) and corresponding 99% confidence intervals (CI) for the effect of RFS and OS of HIPEC in the BRCAm, the HRD/BRCAwt and the non-HRD group were estimated using Cox proportional hazard models. Tumor DNA was available from 200/245 (82%) patients. Seventeen (9%) tumors carried a pathogenic mutation in BRCA1 and 14 (7%) in BRCA2. Ninety-one (46%) tumors classified as BRCA1-like. The effect of HIPEC on RFS and OS was absent in BRCAm tumors (HR 1.25; 99%CI 0.48-3.29), and most present in HRD/BRCAwt (HR 0.44; 99%CI 0.21-0.91), and non-HRD/BRCAwt tumors (HR 0.82; 99%CI 0.48-1.42), interaction P value: 0.024. Patients with HRD tumors without pathogenic BRCA1/2 mutation appear to benefit most from treatment with HIPEC, while benefit in patients with BRCA1/2 pathogenic mutations and patients without HRD seems less evident.

Published
2022

4. Effect of HIPEC according to HRD /BRCA wtgenomic profile in stage III ovarian cancer: Results from the phase III OVHIPEC trial

Author

Koole, Simone N., primary, Schouten, Philip C., additional, Hauke, Jan, additional, Kluin, Roel J. C., additional, Nederlof, Petra, additional, Richters, Lisa K., additional, Krebsbach, Gabriele, additional, Sikorska, Karolina, additional, Alkemade, Maartje, additional, Opdam, Mark, additional, Schagen van Leeuwen, Jules H., additional, Schreuder, Henk W. R., additional, Hermans, Ralph H. M., additional, de Hingh, Ignace H. J. T., additional, Mom, Constantijne H., additional, Arts, Henriette J. G., additional, van Ham, Maaike, additional, van Dam, Peter, additional, Vuylsteke, Peter, additional, Sanders, Joyce, additional, Horlings, Hugo M., additional, van de Vijver, Koen K., additional, Hahnen, Eric, additional, van Driel, Willemien J., additional, Schmutzler, Rita, additional, Sonke, Gabe S., additional, and Linn, Sabine C., additional

Published
2022
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6. Using Diffuse Reflectance Spectroscopy to Distinguish Tumor Tissue From Fibrosis in Rectal Cancer Patients as a Guide to Surgery

Author

Baltussen, Elisabeth J.M., primary, Brouwer de Koning, Susan G., additional, Sanders, Joyce, additional, Aalbers, Arend G.J., additional, Kok, Niels F.M., additional, Beets, Geerard L., additional, Hendriks, Benno H.W., additional, Sterenborg, Henricus J.C.M., additional, Kuhlmann, Koert F.D., additional, and Ruers, Theo J.M., additional

Published
2019
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10. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium

Author

Howat, William J, primary, Blows, Fiona M, additional, Provenzano, Elena, additional, Brook, Mark N, additional, Morris, Lorna, additional, Gazinska, Patrycja, additional, Johnson, Nicola, additional, McDuffus, Leigh-Anne, additional, Miller, Jodi, additional, Sawyer, Elinor J, additional, Pinder, Sarah, additional, van Deurzen, Carolien H M, additional, Jones, Louise, additional, Sironen, Reijo, additional, Visscher, Daniel, additional, Caldas, Carlos, additional, Daley, Frances, additional, Coulson, Penny, additional, Broeks, Annegien, additional, Sanders, Joyce, additional, Wesseling, Jelle, additional, Nevanlinna, Heli, additional, Fagerholm, Rainer, additional, Blomqvist, Carl, additional, Heikkilä, Päivi, additional, Ali, H Raza, additional, Dawson, Sarah-Jane, additional, Figueroa, Jonine, additional, Lissowska, Jolanta, additional, Brinton, Louise, additional, Mannermaa, Arto, additional, Kataja, Vesa, additional, Kosma, Veli-Matti, additional, Cox, Angela, additional, Brock, Ian W, additional, Cross, Simon S, additional, Reed, Malcolm W, additional, Couch, Fergus J, additional, Olson, Janet E, additional, Devillee, Peter, additional, Mesker, Wilma E, additional, Seyaneve, Caroline M, additional, Hollestelle, Antoinette, additional, Benitez, Javier, additional, Perez, Jose Ignacio Arias, additional, Menéndez, Primitiva, additional, Bolla, Manjeet K, additional, Easton, Douglas F, additional, Schmidt, Marjanka K, additional, Pharoah, Paul D, additional, Sherman, Mark E, additional, and García-Closas, Montserrat, additional

Published
2014
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