1. Is the extent of lymphadenectomy a prognostic factor in International Federation of Gynecology and Obstetrics stage <scp>II</scp> endometrioid endometrial cancer?
- Author
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Zeliha Firat Cuylan, Mehmet Mutlu Meydanli, Ali Ayhan, Kemal Güngördük, Murat Gultekin, Huseyin Akilli, Nejat Ozgul, Mehmet Coskun Salman, Oguzhan Kuru, Husnu Celik, Samet Topuz, Esra Kuscu, Hamdullah Sozen, Murat Oz, Mehmet Gökçü, Fuat Demirkiran, Sibel Gokmen, and Tugan Bese
- Subjects
medicine.medical_specialty ,Multivariate analysis ,Turkey ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Adjuvant therapy ,Humans ,Lymph node ,Neoplasm Staging ,Retrospective Studies ,Gynecology ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Endometrial cancer ,Hazard ratio ,Obstetrics and Gynecology ,Prognosis ,medicine.disease ,Confidence interval ,Endometrial Neoplasms ,Dissection ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Lymph Node Excision ,Female ,Lymphadenectomy ,business ,Carcinoma, Endometrioid - Abstract
AIM This study aimed to evaluate the prognostic significance of adequate lymph node dissection (LND) (≥10 pelvic lymph nodes (LNs) and ≥ 5 paraaortic LNs removed) in patients with International Federation of Gynecology and Obstetrics (FIGO) stage II endometrioid endometrial cancer (EEC). METHODS A multicenter department database review was performed to identify patients who had been operated and diagnosed with stage II EEC at seven centers in Turkey retrospectively. Demographic, clinicopathological, and survival data were collected and analyzed. RESULTS We identified 284 women with stage II EEC. There were 170 (59.9%) patients in the adequate lymph node dissection (LND) group and 114 (40.1%) in the inadequate LND group. The 5-year overall survival (OS) rate of the inadequate LND group was significantly lower than that of the adequate LND group (84.1% vs. 89.1%, respectively; p = 0.028). In multivariate analysis, presence of lymphovascular space invasion (LVSI) (hazard ratio [HR]: 2.39, 95% confidence interval [CI]: 1.23-4.63; p = 0.009), age ≥ 60 (HR: 3.30, 95% CI: 1.65-6.57; p = 0.001], and absence of adjuvant therapy (HR: 2.74, 95% CI: 1.40-5.35; p = 0.003) remained as independent risk factors for decreased 5-year disease-free survival (DFS). Inadequate LND (HR: 2.34, 95% CI: 1.18-4.63; p
- Published
- 2021