Search

Your search keyword '"Saksida, Lisa M."' showing total 15 results
Start Over Author "Saksida, Lisa M." Publisher wiley
15 results on '"Saksida, Lisa M."'

1. Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons

Author

Kljakic, Ornela, primary, Janíčková, Helena, additional, Skirzewski, Miguel, additional, Reichelt, Amy, additional, Memar, Sara, additional, El Mestikawy, Salah, additional, Li, Yulong, additional, Saksida, Lisa M., additional, Bussey, Timothy J., additional, Prado, Vania F., additional, and Prado, Marco A. M., additional

Published
2022
Full Text
View/download PDF

3. New frontiers in translational research: Touchscreens, open science, and the mouse translational research accelerator platform

Author

Sullivan, Jacqueline A., primary, Dumont, Julie R., additional, Memar, Sara, additional, Skirzewski, Miguel, additional, Wan, Jinxia, additional, Mofrad, Maryam H., additional, Ansari, Hassam Zafar, additional, Li, Yulong, additional, Muller, Lyle, additional, Prado, Vania F., additional, Prado, Marco A. M., additional, Saksida, Lisa M., additional, and Bussey, Timothy J., additional

Published
2020
Full Text
View/download PDF

4. Selective decrease of cholinergic signaling from pedunculopontine and laterodorsal tegmental nuclei has little impact on cognition but markedly increases susceptibility to stress

Author

Janickova, Helena, primary, Kljakic, Ornela, additional, Rosborough, Kaie, additional, Raulic, Sanda, additional, Matovic, Sara, additional, Gros, Robert, additional, Saksida, Lisa M., additional, Bussey, Timothy J., additional, Inoue, Wataru, additional, Prado, Vania F., additional, and Prado, Marco A. M., additional

Published
2019
Full Text
View/download PDF

15. Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age

Author

Kent, Brianne A, Heath, Christopher J, Kim, Chi Hun, Ahrens, Rosemary, Fraser, Paul E, St George-Hyslop, Peter, Bussey, Timothy J, and Saksida, Lisa M

Subjects
Behavior, Animal, Mice, Transgenic, tau Proteins, Alzheimer's disease, recognition memory, frontotemporal dementia, attention, Disease Models, Animal, Mice, P301L, Cognition, Tauopathies, Reaction Time, Animals, Cognitive Dysfunction, tau, 10. No inequality
Abstract

INTRODUCTION: Tau is a microtubule-associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). These diseases result in the intracellular accumulation of hyperphosphorylated tau in the form of neurofibrillary tangles, the presence of which is associated with cognitive deficits. METHODS: We conducted a longitudinal behavioral study to provide a profile of the TgTau(P301L)23027 transgenic mouse in multiple cognitive domains across multiple ages. P301L is the tau mutation most frequently observed in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and this mouse model recapitulates the progressive development of glial and neurofibrillary tangles, and associated cerebral atrophy observed in patients. We examined frontal cortex-dependent executive function and attention with the touchscreen 5-choice serial reaction time test (5-CSRTT) and assessed the function of temporal cortical structures using novel object recognition (OR). RESULTS: Despite using sensitive tasks, there were no apparent changes in executive function, attention, or recognition memory in the transgenic mice from 5 to 17 months of age. CONCLUSIONS: This study represents the first comprehensive longitudinal analysis of cognition in the TgTauP301L mouse model and suggests that this model is not ideal for studying early attention and recognition memory impairments associated with tauopathy. However, spatial and object recognition memory impairments were observed during follow-up assessments when the mice were 18 and 21 months, respectively. These impairments are consistent with previous publications, and with a dementia-like phenotype in these mice when aged.

Catalog

Books, media, physical & digital resources
See catalog results