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8. Automated radiosynthesis of [ 68 Ga]Ga-PSMA-11 and [ 177 Lu]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications.

Author

Wichmann CW, Ackermann U, Poniger S, Young K, Nguyen B, Chan G, Sachinidis J, and Scott AM

Subjects
Radiochemistry methods, Chemistry Techniques, Synthetic, Prostate-Specific Antigen, Lutetium chemistry, Heterocyclic Compounds, 1-Ring chemistry, Heterocyclic Compounds, 1-Ring chemical synthesis, Gallium Radioisotopes chemistry, Dipeptides chemistry, Dipeptides chemical synthesis, Radioisotopes chemistry, Gallium Isotopes, Radiopharmaceuticals chemical synthesis, Radiopharmaceuticals chemistry, Edetic Acid analogs & derivatives, Edetic Acid chemistry
Abstract

Prostate-specific membrane antigen (PSMA)-targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly changing clinical practice. To facilitate clinical trials, fully automated procedures for the radiosyntheses of [ 68 Ga]Ga-PSMA-11 and [ 177 Lu]Lu-PSMA-617 were developed from commercially available precursors using the cassette based iPHASE MultiSyn module. Formulated and sterile radiopharmaceuticals were obtained in 76 ± 3% (n = 20) and 91 ± 4% (n = 15) radiochemical yields after 17 and 20 min, respectively. Radiochemical purity was always >95% and molar activities exceeded 792 ± 100 and 88 ± 6 GBq/μmol, respectively. Quality control showed conformity with all relevant release criteria and radiopharmaceuticals were used in the clinic., (© 2020 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd.)

Published
2021
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