21 results on '"Søren Overgaard"'
Search Results
2. Intersubjectivity
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Dan Zahavi and Søren Overgaard
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- 2020
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3. The PANSAID randomized clinical trial: A pre‐planned 1‐year follow‐up regarding harm
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Daniel Hägi-Pedersen, Jørn Wetterslev, Søren Overgaard, Kasper Højgaard Thybo, and Ole Mathiesen
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medicine.medical_specialty ,Denmark ,MEDLINE ,Ibuprofen ,1 year follow up ,law.invention ,Danish ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Humans ,Medicine ,Registries ,030212 general & internal medicine ,Adverse effect ,Acetaminophen ,Pain, Postoperative ,business.industry ,030208 emergency & critical care medicine ,General Medicine ,Analgesics, Non-Narcotic ,Acute Pain ,language.human_language ,Anesthesiology and Pain Medicine ,Harm ,Relative risk ,language ,Drug Therapy, Combination ,business ,Follow-Up Studies ,medicine.drug - Abstract
BACKGROUND: Limiting harm from postoperative pain treatment is important. However, long-term follow-up from acute pain trials are rare. The aim of the study was to provide long-term follow-up data regarding harm from the "Paracetamol and Ibuprofen in Combination" (PANSAID) trial.METHODS: In this preplanned long-term follow-up study from the PANSAID trial, we used data from Danish national health registries (the Danish National Patient Registry and the Danish Civil Registration System) in addition to the 90-day follow-up in the original trial. The primary outcome was 1-year proportion of patients with one or more serious adverse events.RESULTS: One-year follow-up was complete for 551 patients (99%). We found three additional patients with one or more serious adverse events in the 1-year follow-up compared with the 90-day follow-up. The relative risk of having one or more serious adverse event when randomized to ibuprofen compared with paracetamol was 1.40 (95% CI: 0.84-2.33, P = .20).CONCLUSION: We found no statistically significant difference in 1-year serious adverse events between patients randomized to ibuprofen compared with paracetamol in patients having planned primary total hip arthroplasty. There were few additional events from the 90-day follow-up to the 1-year follow-up.
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- 2020
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4. Gait analysis for individually tailored interdisciplinary interventions in children with cerebral palsy: a randomized controlled trial
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Ulrike Dunkhase-Heinl, Yanko Petkov, Lars Kjærsgaard Hansen, Vilhelm Engell, Anders Holsgaard-Larsen, Helle Mätzke Rasmussen, Søren Overgaard, and Niels Wisbech Pedersen
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Male ,Orthotic Devices ,030506 rehabilitation ,medicine.medical_specialty ,Psychological intervention ,law.invention ,Cerebral palsy ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Gait (human) ,Developmental Neuroscience ,Quality of life ,Randomized controlled trial ,law ,medicine ,Humans ,Orthopedic Procedures ,Prospective Studies ,Child ,Gait ,Physical Therapy Modalities ,business.industry ,Cerebral Palsy ,Gross Motor Function Classification System ,medicine.disease ,Orthotic device ,Treatment Outcome ,Gait analysis ,Pediatrics, Perinatology and Child Health ,Female ,Neurology (clinical) ,Gait Analysis ,0305 other medical science ,business ,human activities ,030217 neurology & neurosurgery - Abstract
To test the hypothesis that improvements in gait and function following individualized interdisciplinary interventions consisting of physical therapy, orthotics, spasticity management, and orthopaedic surgery using instrumented gait analysis are superior to 'usual care' in children with cerebral palsy (CP).This was a prospective, single-blind, parallel-group, randomized controlled trial investigating the effectiveness of interventions based on the use of gait analysis. Primary outcome was gait (Gait Deviation Index) and secondary outcomes were walking and patient-reported outcome measures of function, disability, and health-related quality of life. Follow-ups were done at 26 weeks (questionnaires) and at the primary end point of 52 weeks (all outcomes).Sixty participants with CP (39 males, 21 females, mean age 6y 10mo, standard deviation 1y 3mo, range 5y-9y 1mo) in Gross Motor Function Classification System levels I or II, were randomized to interventions with or without gait analysis. No significant or clinically relevant between-group differences in change scores of the primary or secondary outcomes were found. The recommended categories of interventions were dominated by non-surgical interventions and were applied in 36% to 86% of the participants.Interventions using gait analysis were not superior to 'usual care' on gait, walking, or patient-reported outcomes in a sample of relatively young and independently walking children with CP not expected to need surgery.Gait analysis in children with cerebral palsy in Gross Motor Function Classification System levels I or II recommends interdisciplinary interventions. Compliance to interventions recommended after gait analysis was low. No statistically significant advantages were identified for the intervention group versus the control group.ANÁLISIS DE MARCHA PARA LA INTERVENCIÓN INTERDISCIPLINARIA ADAPTADA INDIVIDUALMENTE EN NIÑOS CON PARÁLISIS CEREBRAL: ENSAYO CONTROLADO RANDOMIZADO: OBJETIVO: Comprobar la hipótesis que las mejoras en la marcha y la función luego de las intervenciones interdisciplinarias individualizadas de terapia física, ortésis, tratamiento antiespástico, y cirugía ortopédica son superiores que “tratamiento convencional” en parálisis cerebral (PC) utilizando un análisis de marcha instrumentada METODO: Este fue un ensayo randomizado controlado, prospectivo, ciego, con grupo paralelo que investigó la efectividad de intervenciones basada en el uso de análisis de marcha. El resultado primario fue la marcha (Índice de Desviación de la Marcha) y los resultados secundarios fueron el paso y los resultados reportados por los pacientes de función, discapacidad y calidad de vida relacionada a la salud. Los seguimientos se realizaron a las 26 semanas (cuestionarios) y el punto de fin primario de 52 semanas (todos los resultados). RESULTADOS: Sesenta participantes con PC (39 masculinos, 21 femeninos, edad media de 6 años 10 meses, desviación estándar de 1 años y 3 meses, rango 5 años 0 meses- 9 años y 1 mes) con niveles de GMFCS I o II, fueron asignados al azar intervenciones con y sin análisis de marcha. No se encontraron diferencias significativas o clínicamente relevantes entre los grupos en cuanto a los cambios de los resultados primarios y secundarios. INTERPRETACION: Las intervenciones que usaron análisis de marcha no fueron superiores al tratamiento convencional sobre el paso, la marcha o resultados reportados por los pacientes en una muestra de niños con PC relativamente jóvenes y de marcha independiente que no se espera que necesiten cirugía.ANÁLISE DE MARCHA PARA INTERVENÇÕES INDIVIDUALMENTE PLANEJADAS EM CRIANÇAS COM PARALISIA CEREBRAL: UM ENSAIO CONTROLADO RANDOMIZADO: OBJETIVO: Testar a hipótese de que melhoras na marcha e função após intervenções interdisciplinares individualizadas consistindo de fisioterapia, órteses, manejo da espasticidade, e cirurgia ortopédica usando análise de marcha instrumentalizada são superiors comparadas ao “cuidado usual” em crianças com paralisia cerebral (PC). MÉTODO: Este foi um estudo randomizado controlado prospectivo, único cego, com grupos paralelos, investigando a efetividade de intervenções baseadas no uso da análise de marcha. O desfecho primário foi a marcha (Índice de Desvio da Marcha) e os desfechos secundários foram o caminhar e medidas relatadas pelo paciente da função, incapacidade, e qualidade de vida relacionada à saúde. Acompanhamentos foram feitos com 26 semanas (questionários) e o encerramento primário foi 52 semanas (todos os resultados). RESULTADOS: Sessenta participantes com PC (39 do sexo masculino, 21 do sexo feminino, média de idade 6a 10 m, desvio padrão 1a 3 m, variação 5a 0 m- 9a 1 m) nos níveis do Sistema de Classificação da Função Motora Grossa (GMFCS) I ou II foram fandomizados para intervenções com ou sem análise de marcha. Nenhuma diferença significativa ou clinicamente relevante entre grupos nos escores de mudança dos desfechos primários e secundários foram encontradas. As categorias de intervenção recomendadas foram dominadas pelas intervenções não-cirúrgicas e foram aplicadas em 36% a 86% dos participantes. INTERPRETAÇÃO: Intervenções usando análise de marcha não foram superiores ao “cuidado usual” para a marcha, o caminhar, ou resultados reportados por pacientes em ma amostra de crianças com PC relativamente jovens e com deambulação indepente, para a qual não se espera a necessidade de cirurgia.
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- 2019
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5. Microcalorimetric detection of staphylococcal biofilm growth on various prosthetic biomaterials after exposure to daptomycin
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Inês Santos Ferreira, Christen Ravn, Andrej Trampuz, Søren Overgaard, and E. Maiolo
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0301 basic medicine ,biology ,Sonication ,030106 microbiology ,Biofilm ,chemistry.chemical_element ,biochemical phenomena, metabolism, and nutrition ,Polyethylene ,biology.organism_classification ,03 medical and health sciences ,chemistry.chemical_compound ,chemistry ,medicine ,Orthopedics and Sports Medicine ,Daptomycin ,Heat flow ,Bacteria ,Biofilm growth ,Biomedical engineering ,Titanium ,medicine.drug - Abstract
Primary aim of this in vitro study was to test the efficacy of daptomycin to eradicate staphylococcal biofilms on various orthopedic implant materials. Secondary aim was to quantitatively estimate the formation of staphylococcal biofilm. We tested six clinically important biomaterials: Cobalt chrome, pure titanium, grid-blasted titanium, porous plasma-coated titanium with/without hydroxyapatite, and polyethylene. Biofilms of S. aureus and S. epidermidis were formed on the samples and thereafter exposed to daptomycin. Samples were subsequently sonicated in order to detect dislodged biofilm bacteria and transferred to a microcalorimeter for real-time measurement of growth-related heat flow. Minimal biofilm eradication concentration (MBEC) was determined as the lowest concentration of daptomycin required to eradicate biofilm bacteria on the sample. Median MBEC of S. aureus biofilm on smooth metallic surfaces was lower than the rough metallic surfaces. In experiments with S. epidermidis, no pattern was seen in relation to the surface roughness. Regarding the quantitative estimation of staphylococcal biofilm formation on the sample, we found a significantly higher amount of biofilm growth on the rough surfaces than the smooth samples and polyethylene. In conclusion, the presented study showed that daptomycin could eradicate S. aureus biofilm at lower concentrations on the smooth surfaces compared to the rough surfaces, as well as polyethylene. In experiments with daptomycin against S. epidermidis biofilms, no pattern was seen in relation to the surface roughness. Furthermore, we demonstrated a faster detection of staphylococcal heat flow due to higher biofilm quantity on the rough surfaces compared to smooth samples and polyethylene. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2809-2816, 2018.
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- 2018
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6. Optimizing combination of vascular endothelial growth factor and mesenchymal stem cells on ectopic bone formation in SCID mice
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Nicholas Ditzel, Chris Halling Dreyer, Ming Ding, Niklas Rye Jørgensen, Søren Overgaard, and Kristian Kjærgaard
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0301 basic medicine ,biology ,Angiogenesis ,Mesenchymal stem cell ,Metals and Alloys ,Biomedical Engineering ,Vimentin ,Staining ,Biomaterials ,Andrology ,Vascular endothelial growth factor ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,Tissue engineering ,chemistry ,030220 oncology & carcinogenesis ,Immunology ,Ceramics and Composites ,biology.protein ,Immunohistochemistry ,Bone regeneration - Abstract
Introduction: Insufficient blood supply may limit bone regeneration in bone defects. Vascular endothelial growth factor (VEGF) promotes angiogenesis by increasing endothelial migration. This outcome, however, could depend on time of application. Sheep mesenchymal stem cells (MSCs) in severe combined immunodeficient (SCID) mice were used in this study to evaluate optimal time points for VEGF stimulation to increase bone formation. Methods: Twenty-eight SCID (NOD.CB17-Prkdcscid/J) mice had hydroxyapatite (HA) granules seeded with 5x105 MSCs inserted subcutaneously. Pellets released VEGF on Days 1-7, Days 1-14, Days 1-21, Days 1-42, Days 7-14, and Days 21-42. After 8 weeks, the implant-bone-blocks were harvested, paraffin embedded, sectioned, and stained with both Haematoxylin Eosin (HE) and immunohistochemistry for human vimentin staining (hVim). Blood samples were collected for determination of bone-related biomarkers in serum. Results: The groups with 5x105 mesenchymal stem cells and VEGF stimulation on Days 1-14 and Days 1-21 showed more bone formation when compared to the control group of 5x105 mesenchymal stem cells alone (p
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- 2017
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7. Effect of Teriparatide or Risedronate in Elderly Patients With a Recent Pertrochanteric Hip Fracture: Final Results of a 78-Week Randomized Clinical Trial
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Costantino Corradini, Pedro A García-Hernández, Umberto Tarantino, Søren Overgaard, José R. Caeiro, Kyriakos A. Papavasiliou, Jan J. Stepan, Eric Lespessailles, Per Aspenberg, Helmut Petto, Fernando Marin, Frede Frihagen, Jorge Malouf-Sierra, and Lars C. Borris
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musculoskeletal diseases ,medicine.medical_specialty ,Visual analogue scale ,Endocrinology, Diabetes and Metabolism ,Urology ,030209 endocrinology & metabolism ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Teriparatide ,medicine ,Clinical endpoint ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Femoral neck ,Hip fracture ,business.industry ,Repeated measures design ,medicine.disease ,3. Good health ,Surgery ,medicine.anatomical_structure ,Orthopedic surgery ,business ,medicine.drug - Abstract
We present final results of a study comparing teriparatide 20 μg every day (QD) with risedronate 35 mg once per week (QW) started within 2 weeks after surgery for a pertrochanteric hip fracture. Patients with BMD T-score ≤ -2.0 and 25OHD ≥9.2 ng/mL were randomized to receive 26-week double-dummy treatment plus calcium and vitamin D, followed by 52-week open-label treatment with the same assigned active drug. Primary endpoint was change from baseline in lumbar spine (LS) BMD at 78 weeks. Secondary and exploratory endpoints were change in BMD at the proximal femur, function, hip pain (Charnley score and 100 mm Visual Analog Scale [VAS]), quality of life (Short Form-36), radiology outcomes, and safety. Data were analyzed with mixed models for repeated measures (MMRM) and logistic regression. Totally, 224 patients were randomized; 171 (teriparatide: 86) contributed to the efficacy analyses (mean ± SD age: 77 ± 7.7 years, 77% females). Mean baseline LS, femoral neck (FN), and total hip (TH) T-scores were -2.16, -2.63, and -2.51, respectively. At 78 weeks, BMD increased significantly more with teriparatide compared to risedronate at the LS (+11.08% versus +6.45%; p < 0.001) and FN (+1.96% versus -1.19%; p = 0.003), with no significant between-group difference in TH BMD. Timed up-and-go (TUG) test was significantly faster with teriparatide at 6, 12, 18, and 26 weeks (differences: -3.2 to -5.9 s; p = 0.045 for overall difference). Hip pain during TUG test by 100 mm VAS was significantly lower with teriparatide at 18 weeks (adjusted difference: -11.3 mm, p = 0.033; -10.0 and -9.3 mm at 12 and 26 weeks, respectively; p = 0.079 for overall difference). Other secondary and exploratory outcomes were not different. Teriparatide group showed two new hip fractures versus seven with risedronate (p = 0.171) and more frequent hypercalcemia and hyperuricemia. In conclusion, 78-week treatment with teriparatide showed significantly greater increases in LS and FN BMD, less pain, and a faster TUG test versus risedronate. © 2016 American Society for Bone and Mineral Research.
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- 2017
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8. Agreement and precision of periprosthetic bone density measurements in micro-CT, single and dual energy CT
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Peter Traise, Bo Redder Mussmann, Trine Torfing, Søren Overgaard, Oke Gerke, and Poul Erik Andersen
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Bone mineral ,Materials science ,Bone density ,Intraclass correlation ,business.industry ,Periprosthetic ,Dual-Energy Computed Tomography ,Imaging phantom ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Orthopedics and Sports Medicine ,Dual energy ct ,Micro ct ,Nuclear medicine ,business - Abstract
The objective of this study was to test the precision and agreement between bone mineral density measurements performed in micro CT, single and dual energy computed tomography, to determine how the keV level influences density measurements and to assess the usefulness of quantitative dual energy computed tomography as a research tool for longitudinal studies aiming to measure bone loss adjacent to total hip replacements. Samples from 10 fresh-frozen porcine femoral heads were placed in a Perspex phantom and computed tomography was performed with two acquisition modes. Bone mineral density was calculated and compared with measurements derived from micro CT. Repeated scans and dual measurements were performed in order to measure between- and within-scan precision. Mean density difference between micro CT and single energy computed tomography was 72 mg HA/cm3. For dual energy CT, the mean difference at 100 keV was 128 mg HA/cm3 while the mean difference at 110–140 keV ranged from −84 to −67 mg HA/cm3 compared with micro CT. Rescanning the samples resulted in a non-significant overall between-scan difference of 13 mg HA/cm3. Bland–Altman limits of agreement were wide and intraclass correlation coefficients ranged from 0.29 to 0.72, while 95% confidence intervals covered almost the full possible range. Repeating the density measurements for within-scan precision resulted in ICCs >0.99 and narrow limits of agreement. Single and dual energy quantitative CT showed excellent within-scan precision, but poor between-scan precision. No significant density differences were found in dual energy quantitative CT at keV-levels above 110 keV. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1470–1477, 2017.
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- 2016
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9. 3D perfusion bioreactor-activated porous granules on implant fixation and early bone formation in sheep
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Susan Snoek Henriksen, Roberta Martinetti, Søren Overgaard, and Ming Ding
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0301 basic medicine ,medicine.medical_specialty ,Materials science ,0206 medical engineering ,Biomedical Engineering ,Synthetic graft ,02 engineering and technology ,Fibrous tissue ,020601 biomedical engineering ,Perfusion bioreactor ,Surgery ,Biomaterials ,Implant fixation ,03 medical and health sciences ,surgical procedures, operative ,030104 developmental biology ,Bone graft materials ,medicine ,Bone formation ,Implant ,Biomedical engineering ,Fixation (histology) - Abstract
Early fixation of total joint arthroplasties is crucial for ensuring implant survival. An alternative bone graft material in revision surgery is needed to replace the current gold standard, allograft, seeing that the latter is associated with several disadvantages. The incubation of such a construct in a perfusion bioreactor has been shown to produce viable bone graft materials. This study aimed at producing larger amounts of viable bone graft material (hydroxyapatite 70% and β-tricalcium-phosphate 30%) in a novel perfusion bioreactor. The abilities of the bioreactor-activated graft material to induce early implant fixation were tested in a bilateral implant defect model in sheep, with allograft as the control group. Defects were bilaterally created in the distal femurs of the animals, and titanium implants were inserted. The concentric gaps around the implants were randomly filled with either allograft, granules, granules with bone marrow aspirate or bioreactor-activated graft material. Following an observation time of 6 weeks, early implant fixation and bone formation were assessed by micro-CT scanning, mechanical testing, and histomorphometry. Bone formations were seen in all groups, while no significant differences between groups were found regarding early implant fixation. The microarchitecture of the bone formed by the synthetic graft materials resembled that of allograft. Histomorphometry revealed that allograft induced significantly more bone and less fibrous tissue (p
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- 2016
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10. An automated perfusion bioreactor for the streamlined production of engineered osteogenic grafts
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Ming Ding, David Wendt, Susan Snoek Henriksen, and Søren Overgaard
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0301 basic medicine ,Stromal cell ,Materials science ,Mesenchymal stem cell ,Granule (cell biology) ,Biomedical Engineering ,Biomaterials ,03 medical and health sciences ,Tissue culture ,030104 developmental biology ,medicine.anatomical_structure ,Tissue engineering ,medicine ,Bioreactor ,Bone marrow ,Bone regeneration ,Biomedical engineering - Abstract
A computer-controlled perfusion bioreactor was developed for the streamlined production of engineered osteogenic grafts. This system automated the required bioprocesses, from the initial filling of the system through the phases of cell seeding and prolonged cell/tissue culture. Flow through chemo-optic micro-sensors allowed to non-invasively monitor the levels of oxygen and pH in the perfused culture medium throughout the culture period. To validate its performance, freshly isolated ovine bone marrow stromal cells were directly seeded on porous scaffold granules (hydroxyapatite/β-tricalcium-phosphate/poly-lactic acid), bypassing the phase of monolayer cell expansion in flasks. Either 10 or 20 days after culture, engineered cell-granule grafts were implanted in an ectopic mouse model to quantify new bone formation. After four weeks of implantation, histomorphometry showed more bone in bioreactor-generated grafts than cell-free granule controls, while bone formation did not show significant differences between 10 days and 20 days of incubation. The implanted granules without cells had no bone formation. This novel perfusion bioreactor has revealed the capability of activation larger viable bone graft material, even after shorter incubation time of graft material. This study has demonstrated the feasibility of engineering osteogenic grafts in an automated bioreactor system, laying the foundation for a safe, regulatory-compliant, and cost-effective manufacturing process.
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- 2015
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11. Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep
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Ming Ding, Anders E. Jensen, Mads L. Dencker, Christina Møller Andreasen, Søren Overgaard, and Naseem Theilgaard
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chemistry.chemical_classification ,medicine.medical_specialty ,Materials science ,Metals and Alloys ,Biomedical Engineering ,Biomaterial ,Peptide ,Biomaterials ,Implant fixation ,Cell binding ,chemistry ,Orthopedic surgery ,Ceramics and Composites ,medicine ,Bone formation ,Implant ,Fixation (histology) ,Biomedical engineering - Abstract
Cylindrical critical size defects were created at the distal femoral condyles bilaterally of eight female adult sheep. Titanium implants with 2-mm concentric gaps were inserted and the gaps were filled with one of the four materials: allograft; a synthetic 15-amino acid cell-binding peptide coated hydroxyapatite (ABM/P-15); hydroxyapatite + βtricalciumphosphate+ Poly-Lactic-Acid (HA/βTCP-PDLLA); or ABM/P-15+HA/βTCP-PDLLA. After nine weeks, bone-implant blocks were harvested and sectioned for micro-CT scanning, push-out test, and histomorphometry. Significant bone formation and implant fixation could be observed in all four groups. Interestingly, the microarchitecture of the ABM/P-15 group was significantly different from the control group. Tissue volume fraction and thickness were significantly greater in the ABM/P-15 group than in the allograft group. Bone formation and bone ingrowth to porous titanium implant were not significantly different among the four groups. The ABM/P-15 group had similar shear mechanical properties on implant fixation as the allograft group. Adding HA/βTCP-PDLLA to ABM/P-15 did not significantly change these parameters. This study revealed that ABM/P-15 had significantly bone formation in concentric gap, and its enhancements on bone formation and implant fixation were at least as good as allograft. It is suggested that ABM/P-15 might be a good alternative biomaterial for bone implant fixation in this well-validated critical-size defect gap model in sheep. Nevertheless, future clinical researches should focus on prospective, randomized, controlled trials in order to fully elucidate whether ABM/P-15 could be a feasible candidate for bone substitute material in orthopedic practices.
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- 2014
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12. ON THE LOOKS OF THINGS
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Søren Overgaard
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Perception ,media_common.quotation_subject ,Criticism ,General Medicine ,Sociology ,Visual experience ,Characterization (mathematics) ,Constant (mathematics) ,Epistemology ,media_common - Abstract
In recent publications, Michael Tye and Alva Noe have claimed that there is a sense in which a tilted plate looks round and another sense in which it looks elliptical. This paper argues that their proposal faces decisive objections. On Tye and Noe's account of ordinary, veridical perception, appearances are in constant conflict. As a characterization of ordinary visual experience, this cannot be correct. I examine various responses to this criticism, and conclude that they all fail. I then argue that Noe's account has the further, unintended and undesirable consequence of promoting a version of the sense-datum theory.
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- 2010
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13. Hip Fracture Patients at Risk of Second Hip Fracture: A Nationwide Population-Based Cohort Study of 169,145 Cases During 1977–2001
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Peter Vestergaard, Lars Rejnmark, Søren Overgaard, Kim Brixen, and Jesper Ryg
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Male ,medicine.medical_specialty ,Denmark ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Population ,Population based cohort ,Sex Factors ,Risk Factors ,Internal medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Cumulative incidence ,Registries ,education ,Aged ,Aged, 80 and over ,Hip fracture ,education.field_of_study ,Hip Fractures ,business.industry ,Incidence (epidemiology) ,Age Factors ,Middle Aged ,medicine.disease ,Comorbidity ,Surgery ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Udgivelsesdato: July Abstract In patients with prior hip fracture (HFx), little is known about time frame and risk factors of second HFx, as well as the ensuing mortality. The aim of the study was to elucidate the incidence of second HFx and the subsequent mortality. All 169,145 patients with a first HFx in Denmark during 1977-2001 were followed for up to 25 years and compared with the background population. Data on fractures, vital status, comorbidity, redeemed prescriptions, and socio-demographic variables were retrieved from national registers. Median follow-up was 3.8 years corresponding 1,041,177 patient years. A total of 27,834 patients suffered a second HFx. The cumulative incidence was 9% after 1 year and 20% after 5 years, being significantly higher than expected (2% and 12%, respectively, p
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- 2009
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14. HOW TO ANALYZE IMMEDIATE EXPERIENCE
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Søren Overgaard
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Phenomenology (philosophy) ,Philosophy ,Analytic philosophy ,Epistemology ,Philosophical methodology - Abstract
This article discusses Jaakko Hintikka's interpretation of the aims and method of Husserl's phenomenology. I argue that Hintikka misrepresents Husserl's phenomenology on certain crucial points. More specifically, Hintikka misconstrues Husserl's notion of “immediate experience” and consequently fails to grasp the functions of the central methodological tools known as the “epoche” and the “phenomenological reduction.” The result is that the conception of phenomenology he attributes to Husserl is very far from realizing the philosophical potential of Husserl's position. Hence if we want a fruitful rapprochement between analytical philosophy and Continental phenomenology of the kind that is Hintikka's ultimate aim, then Hintikka's account of Husserl needs correcting on a number of crucial points.
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- 2008
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15. No effect of hydroxyapatite particles in phagocytosable sizes on implant fixation: An experimental study in dogs
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Knud Bendix, Søren Kold, Søren Overgaard, Ole Rahbek, and Kjeld Søballe
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Bone Regeneration ,Materials science ,Wear debris ,Biomedical Engineering ,Dentistry ,Biocompatible Materials ,Bone healing ,Biomaterials ,chemistry.chemical_compound ,Dogs ,Phagocytosis ,In vivo ,Hyaluronic acid ,medicine ,Animals ,Hyaluronic Acid ,Fixation (histology) ,Analysis of Variance ,business.industry ,Metals and Alloys ,Osteoblast ,Prostheses and Implants ,Polyethylene ,Durapatite ,medicine.anatomical_structure ,chemistry ,Microscopy, Electron, Scanning ,Ceramics and Composites ,Implant ,business - Abstract
The influence of wear debris on bone healing around orthopedic implants is debated. Hydroxyapatite (HA) particles and polyethylene (PE) particles have been shown to have a negative effect on osteoblast cultures in vitro. The present study investigated the in vivo effects of HA and PE particles on the mechanical fixation and gap healing around experimental HA implants. Nonloaded implants (n = 30) were inserted bilaterally into the proximal tibia of 15 dogs with a 2-mm gap to the bone. The peri-implant gap was either (1) empty (n = 6) or filled with (2) hyaluronic acid (n = 8), (3) hyaluronic acid and HA particles (n = 8), or (4) hyaluronic acid and PE particles (n = 8). After 4 weeks, the animals were killed. The implant interface was evaluated by pushout testing until failure and by histomorphometry. Both HA and PE particles were found to be phagocytosed by macrophage-like cells in the interfacial tissue. HA particles were also integrated in newly formed bone. We found no negative effect of the particulate material on mechanical fixation of the implants or on bone formation around the implants.
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- 2005
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16. Effect of osteogenic protein 1/collagen composite combined with impacted allograft around hydroxyapatite-coated titanium alloy implants is moderate
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Kjeld Søballe, Thomas Bo Jensen, Yong Song, Søren Overgaard, Cody Bünger, Martin Lind, and Stuart B. Goodman
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Materials science ,Bone Morphogenetic Protein 7 ,medicine.medical_treatment ,Biomedical Engineering ,Dentistry ,Biocompatible Materials ,Bone healing ,Prosthesis ,Biomaterials ,Dogs ,Coated Materials, Biocompatible ,Osteogenesis ,Transforming Growth Factor beta ,Materials Testing ,medicine ,Animals ,Transplantation, Homologous ,Humerus ,Fixation (histology) ,Titanium ,Bone Transplantation ,business.industry ,Growth factor ,Titanium alloy ,Biomaterial ,Prostheses and Implants ,Biomechanical Phenomena ,medicine.anatomical_structure ,Bone Morphogenetic Proteins ,Cattle ,Collagen ,Hydroxyapatites ,Stress, Mechanical ,Implant ,business - Abstract
This study evaluated the effects of osteogenic protein 1/collagen composite (OP-1 /col) mixed with impacted allograft around hydroxyapatite (HA)-coated titanium alloy implants in a canine model. The aim of the study was to test different doses of OP-1 growth factor in a collagen composite for stimulatory effect on allograft incorporation around an implant. Unloaded implants were inserted in each proximal humerus of 16 skeletally mature dogs. The cylindrical implants (4 x 9 mm) coated with HA were initially surrounded by a 3-mm gap into which allograft mixed with OP-1/col was impacted. Two different doses of OP-1 were investigated. In eight animals 325 mg OP-1 protein and 130 mg bovine collagen type I as carrier were mixed with the allograft chips. This composite is identical to the clinically used OP-1 device called Novus. In another eight animals a lower dose of 65 mg OP-1 protein and 130 mg bovine collagen type I was used. Control implants placed in the contralateral humerus were surrounded by allograft mixed with collagen carrier only. The dogs were euthanized at 6 weeks. Implant fixation was determined by push-out testing. Bone ingrowth and bone formation were evaluated by quantitative histomorphometry on serial sections of the bone-implant interface. Impacted allograft together with low-dose OP-1 enhanced bone volume in a zone adjacent to HA-coated titanium alloy implants. The high dose had no effect on bone formation. Mechanical fixation, bone ingrowth, and bone volume in the gap near the original trabecular bone were unaffected by both low and high OP-1/col composite. In this model and observation period, the low dose of OP-1 /col composite mixed with impacted allograft has a moderate effect on bone healing around HA-coated implants and no effect on implant fixation.
- Published
- 2001
- Full Text
- View/download PDF
17. Efficiency of systematic sampling in histomorphometric bone research illustrated by hydroxyapatite-coated implants: Optimizing the stereological vertical-section design
- Author
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Kjeld Søballe, Søren Overgaard, and Hans Jørgen G. Gundersen
- Subjects
Microscope ,Sampling efficiency ,law ,Statistics ,Sampling design ,Microtome ,Sampling (statistics) ,Orthopedics and Sports Medicine ,Systematic sampling ,Variance (accounting) ,Implant ,Mathematics ,law.invention - Abstract
The sampling efficiency of the unbiased stereological vertical-section method was analyzed in five hydroxyapatite-coated implants. They were inserted into humans and harvested after 1 year. To find an optimal sampling design for histomorphometric analyses, sampling efficiency was estimated by variance analyses at different sampling levels (humans, sections, fields of view, and number of counting items) and intensities. Only minor changes in variance were observed when the initial scheme was reduced to include just one of the two possible implant sides, every third field of view, and half the density of the probe; this reduced the total workload at the microscope to less than 10% for all sections. In addition, the number of sections for analysis could be reduced to every fourth section per implant (three to four sections for evaluation) without significantly increasing variance. The study demonstrated that biological variation contributed to the majority of the total observed variance. Optimizing the sampling design could significantly reduce the workload at the hard-tissue microtome and the microscope without reducing the quality of the data that were unbiased and that had low sampling variance as compared with the true biological variation.
- Published
- 2000
- Full Text
- View/download PDF
18. Role of different loading conditions on resorption of hydroxyapatite coating evaluated by histomorphometric and stereological methods
- Author
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Ebbe Stender Hansen, Kjeld Søballe, Søren Overgaard, Cody Bünger, and Kaj Josephsen
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Materials science ,Medial femoral condyle ,Scanning electron microscope ,business.industry ,Metal implant ,chemistry.chemical_element ,Dentistry ,Resorption ,chemistry ,Hydroxyapatite coating ,Orthopedics and Sports Medicine ,Implant ,business ,Titanium - Abstract
The role of different loading conditions on resorption of plasma-sprayed hydroxyapatite coating was investigated in an experimental study. Resorption of hydroxyapatite was quantified by histomorphometric and stereological methods on backscattered scanning electron images. Hydroxyapatite-coated titanium implants were inserted unilaterally into the medial femoral condyle of the knee in 14 mature dogs. Initially, all implants were subjected to controlled micromotion of 150 microns. After 4 weeks, the dogs were randomly assigned either to have the implant surgically immobilized to prevent further micromovement or to have a sham operation. Sixteen weeks after the first operation, the implants were analyzed. Six noninserted implants served as controls. The surface area and volume of the hydroxyapatite coating were reduced on the immobilized implants by 53 and 67% (p < 0.05), respectively, and were further significantly reduced on the continuously loaded implants by 83 and 87%, respectively, compared with the control implants. The hydroxyapatite coating was significantly thinner on immobilized (15 microns) and continuously loaded (15 microns) implants as compared with control implants (23 microns), but no difference between the inserted implants was found. Areas not covered with hydroxyapatite had 29 and 24% bone coverage on the immobilized and continuously loaded implants (not significant). Resorption of hydroxyapatite coating did occur in vivo. Continuous loading of the implants accelerated resorption significantly compared with immobilization of the implants. It is suggested that completely resorbed hydroxyapatite was partly replaced by bone in direct contact with the metal implant surface.
- Published
- 1996
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19. Transforming growth factor-β1 enhances bone healing to unloaded tricalcium phosphate coated implants: An experimental study in dogs
- Author
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Cody Bünger, Tue Nguyen, Kjeld Søballe, Søren Overgaard, Boonsri Ongpipattanakul, and Martin Lind
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Bone growth ,Materials science ,biology ,business.industry ,Osteoporosis ,Dentistry ,chemistry.chemical_element ,Transforming growth factor beta ,Bone healing ,Calcium ,medicine.disease ,chemistry ,medicine ,biology.protein ,Orthopedics and Sports Medicine ,Implant ,business ,Bone volume ,Fixation (histology) - Abstract
Growth of bone into cementless prosthetic components is compromised after revision of failed joint prostheses and by osteoporosis, gaps, and micromotion. We studied the effects of recombinant human transforming growth factor-beta 1 adsorbed on ceramic coated implants on the improvement of mechanical fixation and bone growth on the implant. Unloaded cylindrical grit-blasted titanium alloy implants were inserted bilaterally into both the medial and lateral femoral condyles of 10 skeletally mature mongrel dogs. The implants measured 10 mm in length and 6 mm in diameter and were initially surrounded by a 2 mm gap. One implant had an uncoated titanium surface and three implants were coated with tricalcium phosphate and 0, 0.3, or 3.0 micrograms of recombinant human transforming growth factor-beta 1. The dogs were killed at 6 weeks. Mechanical testing showed a 3-fold increase in fixation for the 0.3 microgram dose of recombinant human transforming growth factor-beta 1 and a 2-fold increase for the 3.0 micrograms dose. Histological analysis of bone growth on the implant demonstrated that maximal stimulation occurred with the 0.3 microgram dose, but bone volume in the gap was maximally stimulated by the 3.0 micrograms dose and increased 2-fold over control values. The majority of tricalcium phosphate was resorbed after the 6-week observation period. This study suggests that recombinant human transforming growth factor-beta 1 adsorbed onto implants coated with tricalcium phosphate ceramic can enhance mechanical fixation and bone growth on the implant. The use of transforming growth factor-beta 1 on ceramic coated prosthetic components may help to improve the functional outcome of cementless total joint replacements.
- Published
- 1996
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20. Mixed bacterial meningitis in an adult caused byHaemophilus influenzaeandStreptococcus pneumoniae
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Poul Kjaeldgaard, Berit Lukman, Annette Jensen, and Søren Overgaard
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Microbiology (medical) ,business.industry ,General Medicine ,medicine.disease_cause ,Pathology and Forensic Medicine ,Microbiology ,Haemophilus influenzae ,Ampicillin ,Streptococcus pneumoniae ,medicine ,Immunology and Allergy ,Bacterial meningitis ,business ,After treatment ,medicine.drug - Abstract
A case of mixed bacterial meningitis with Haemophilus influenzae and Streptococcus pneumoniae is reported in a 26-year-old woman without demonstrable predisposing conditions, who recovered after treatment with ampicillin, without sequelae.
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- 1990
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21. S647 PREOPERATIVE MENTAL HEALTH AND QUALITY OF LIFE IN PATIENTS WITH SHOULDER AND HIP PAIN
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Kirsten Kaya Roessler, Randi Bilberg, Birgitte Nørgaard, and Søren Overgaard
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medicine.medical_specialty ,Pathology ,business.industry ,Plant biology ,Mental health ,Anesthesiology and Pain Medicine ,Quality of life (healthcare) ,Anesthesiology ,medicine ,Physical therapy ,In patient ,Hip pain ,business - Published
- 2011
- Full Text
- View/download PDF
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