Search

Your search keyword '"Russell, David G."' showing total 24 results
Start Over Author "Russell, David G." Publisher wiley
24 results on '"Russell, David G."'

4. Cholesterol Metabolism in Mycobacterium tuberculosis: Chewing Through the Fat

Author

Nesbitt, Natasha Monic, primary, Dubnau, Eugenie, additional, Kisker, Caroline, additional, Lu, Rui, additional, Russell, David G, additional, Schäfer, Christin, additional, Sherman, David R, additional, Smith, Issar, additional, Thomas, Suzanne T, additional, VanderVen, Brian C, additional, Yang, Xinxin, additional, and Sampson, Nicole S, additional

Published
2012
Full Text
View/download PDF

16. M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)

Author

Owens, Roisin M., primary, Hsu, Fong Fu, additional, VanderVen, Brian C., additional, Purdy, Georgiana E., additional, Hesteande, Elizabeth, additional, Giannakas, Peter, additional, Sacchettini, James C., additional, McKinney, John D., additional, Hill, Preston J., additional, Belisle, John T., additional, Butcher, Barbara A., additional, Pethe, Kevin, additional, and Russell, David G., additional

Published
2006
Full Text
View/download PDF

18. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence

Author

Movahedzadeh, Farahnaz, primary, Smith, Debbie A., additional, Norman, Richard A., additional, Dinadayala, Premkumar, additional, Murray-Rust, Judith, additional, Russell, David G., additional, Kendall, Sharon L., additional, Rison, Stuart C. G., additional, McAlister, Mark S. B., additional, Bancroft, Gregory J., additional, McDonald, Neil Q., additional, Daffe, Mamadou, additional, Av-Gay, Yossef, additional, and Stoker, Neil G., additional

Published
2003
Full Text
View/download PDF

24. Macrophage activation downregulates the degradative capacity of the phagosome.

Author

Yates RM, Hermetter A, Taylor GA, and Russell DG

Subjects
Animals, Antigen Presentation, Down-Regulation, Fluorometry, Hydrolysis, Interferon-gamma immunology, Kinetics, Lipopolysaccharides immunology, Lysosomes enzymology, Lysosomes metabolism, Macrophages cytology, Macrophages enzymology, Macrophages immunology, Mice, Mice, Inbred C57BL, Phagosomes enzymology, Macrophage Activation, Macrophages metabolism, Phagosomes metabolism
Abstract

The phagosome is key to most macrophage functions. It is the site of degradation of particulate material, of bacterial killing and the generation of peptides for antigen presentation. Despite its role at the fulcrum of the innate and acquired immune systems, little is known about the physiology of this organelle in activated macrophages. In this study, we utilize fluorometric techniques to characterize functional alterations in the lumenal environment of the maturing phagosome following stimulation of macrophages with interferon-gamma and/or lipopolysaccharide. In addition to modulating the kinetics of phagosomal acidification, activation results in a phagosome with diminished hydrolytic activities that varies markedly with the activation status of the cell. Differential levels of proteolytic, lipolytic and beta-galactosidase activities were observed in the phagosome but not in the total lysosomal extract, indicating selective delivery of enzymes to the developing phagosome. Despite the suppression of hydrolytic activities observed in early phagosomes, late phagosomes exhibit an enhanced and protracted accumulation of lysosomal cargo. The data are consistent with limiting proteolysis in the early phagosome to maximize epitope generation and antigen presentation while sequestering the degradative capacity in the late phagolysosome.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results