Search

Your search keyword '"Roose T"' showing total 17 results
Start Over Author "Roose T" Publisher wiley
17 results on '"Roose T"'

2. The effect of non-uniform microscale distribution of sorption sites on solute diffusion in soil

Author

Masum, Shakil, Kirk, Guy J. D., Daly, K. R., and Roose, T.

Abstract

Conventional models of solute transport in soil consider only soil volumes large enough to average over microscale heterogeneities, and it is assumed that microscale variations are unimportant at the macroscale. In this research we test this assumption for cases in which the microscale distribution of solute-sorbing sites is patchy. We obtain a set of equations at the macroscale that allow for the effect of the microscale distribution with the mathematical technique of homogenization. We combine these equations with an image-based model that describes the true microscale pore geometry in a real, structured soil measured with X-ray computed tomography. The resulting models are used to test the microscale averaging assumptions inherent in conventional models. We show that, in general, macroscale diffusion is little affected by microscale variation in the distribution of sorption sites. Therefore, for most purposes the assumption of microscale averaging used in conventional models is justified. The effects of microscale heterogeneity are noticeable only when (i) the rate of sorption is slow compared with diffusion, but still fast enough to affect macroscale transport and (ii) the defined macroscale volume approaches the microscale. We discuss the effects when these conditions are met

Published
2016

8. Modeling Soil Processes: Review, Key Challenges, and New Perspectives

Author

Vereecken, H., primary, Schnepf, A., additional, Hopmans, J.W., additional, Javaux, M., additional, Or, D., additional, Roose, T., additional, Vanderborght, J., additional, Young, M.H., additional, Amelung, W., additional, Aitkenhead, M., additional, Allison, S.D., additional, Assouline, S., additional, Baveye, P., additional, Berli, M., additional, Brüggemann, N., additional, Finke, P., additional, Flury, M., additional, Gaiser, T., additional, Govers, G., additional, Ghezzehei, T., additional, Hallett, P., additional, Hendricks Franssen, H.J., additional, Heppell, J., additional, Horn, R., additional, Huisman, J.A., additional, Jacques, D., additional, Jonard, F., additional, Kollet, S., additional, Lafolie, F., additional, Lamorski, K., additional, Leitner, D., additional, McBratney, A., additional, Minasny, B., additional, Montzka, C., additional, Nowak, W., additional, Pachepsky, Y., additional, Padarian, J., additional, Romano, N., additional, Roth, K., additional, Rothfuss, Y., additional, Rowe, E.C., additional, Schwen, A., additional, Šimůnek, J., additional, Tiktak, A., additional, Van Dam, J., additional, van der Zee, S.E.A.T.M., additional, Vogel, H.J., additional, Vrugt, J.A., additional, Wöhling, T., additional, and Young, I.M., additional

Published
2016
Full Text
View/download PDF

17. A four-compartment multiscale model of fluid and drug distribution in vascular tumours.

Author

Shipley RJ, Sweeney PW, Chapman SJ, and Roose T

Subjects
Computer Simulation, Humans, Vascular Neoplasms, Drug Therapy methods, Models, Theoretical
Abstract

The subtle relationship between vascular network structure and mass transport is vital to predict and improve the efficacy of anticancer treatments. Here, mathematical homogenisation is used to derive a new multiscale continuum model of blood and chemotherapy transport in the vasculature and interstitium of a vascular tumour. This framework enables information at a range of vascular hierarchies to be fed into an effective description on the length scale of the tumour. The model behaviour is explored through a demonstrative case study of a simplified representation of a dorsal skinfold chamber, to examine the role of vascular network architecture in influencing fluid and drug perfusion on the length scale of the chamber. A single parameter, P, is identified that relates tumour-scale fluid perfusion to the permeability and density of the capillary bed. By fixing the topological and physiological properties of the arteriole and venule networks, an optimal value for P is identified, which maximises tumour fluid transport and is thus hypothesised to benefit chemotherapy delivery. We calculate the values for P for eight explicit network structures; in each case, vascular intervention by either decreasing the permeability or increasing the density of the capillary network would increase fluid perfusion through the cancerous tissue. Chemotherapeutic strategies are compared and indicate that single injection is consistently more successful compared with constant perfusion, and the model predicts optimal timing of a second dose. These results highlight the potential of computational modelling to elucidate the link between vascular architecture and fluid, drug distribution in tumours., (© 2020 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.)

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results