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Your search keyword '"Roel Anthonissen"' showing total 2 results
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2 results on '"Roel Anthonissen"'

1. Investigation into the Genotoxicity of Water Extracts from Hypoxis Species and a Commercially Available Hypoxis Preparation

Author

B. Mertens, Roel Anthonissen, Luc Verschaeve, B. Gorissen, J. Van Staden, and Ashwell R. Ndhlala

Subjects
Pharmacology, Neutral red, Traditional medicine, Hypoxis hemerocallidea, Biology, Alkaline Comet Assay, medicine.disease_cause, biology.organism_classification, Molecular biology, Comet assay, chemistry.chemical_compound, chemistry, Hepg2 cells, medicine, Hypoxis, Cytotoxicity, Genotoxicity
Abstract

We performed an in vitro evaluation of the genotoxic potential of water extracts from four Hypoxis species (Hypoxis hemerocallidea, H. colchicifolia, H. rigidula, H. acuminata) and a commercial preparation thereof using the neutral red uptake (NRU) assay, the alkaline comet assay and the cytome assay in human hepatoma HepG2 cells. The relative cytotoxicity of these samples was established by determining their NI50 values (50% inhibition of NRU), and these results were used for dose-finding in genotoxicity tests. None of the tested extracts were identified as genotoxic in both the alkaline comet assay and cytome assay. Copyright © 2012 John Wiley & Sons, Ltd.

Published
2012

2. Genotoxicity investigation of ELF-magnetic fields in Salmonella typhimurium with the sensitive SOS-based VITOTOX test

Author

Annemarie Maes, Jakub Wudarski, Lieven Gevaert, L. Verschaeve, Magda Grudniewska, and Roel Anthonissen

Subjects
Salmonella typhimurium, endocrine system, Salmonella, Chemical mutagens, Physiology, DNA damage, Biophysics, medicine.disease_cause, Sensitivity and Specificity, Microbiology, SOS Response (Genetics), medicine, Radiology, Nuclear Medicine and imaging, SOS response, SOS Response, Genetics, Biology, Reporter gene, biology, Mutagenicity Tests, Chemistry, food and beverages, General Medicine, biology.organism_classification, Molecular biology, Magnetic Fields, bacteria, Human medicine, Genotoxicity, Bacteria, DNA Damage, Mutagens
Abstract

We performed a genotoxicity investigation of extremely low-frequency (ELF) magnetic fields (MFs, 50 Hz, 100 and 500 µT, 1 and 2 h exposure) alone and in combination with known chemical mutagens using the VITOTOX test. This test is a very sensitive reporter assay of Salmonella typhimurium bacteria based on the SOS response. Our study showed that ELF-MFs do not induce SOS-based mutagenicity in S. typhimurium bacteria and do not show any synergetic effect when combined with chemical mutagens.

Published
2011

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