1. The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
- Author
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Rocky Vig, Raymond F. Palmer, Deydeep Kothapalli, Raul Vintimilla, Sid E. O'Bryant, Fan Zhang, Yonggang Shi, Meredith N. Braskie, Kristine Yaffe, Bradley T. Christian, Stephanie Large, James Hall, Elizabeth Matsiyevskiy, David C. Mason, Melissa Petersen, Rajesh Nandy, Arthur W. Toga, Kevin S. King, Robert A. Rissman, Roderick W McColl, Leigh Johnson, Nalini Hazra, Nicole Philips, and Robert Barber
- Subjects
Gerontology ,Significant group ,Hispanic ,Mexican americans ,diversity ,03 medical and health sciences ,mild cognitive impairment ,0302 clinical medicine ,Study methods ,Aging brain ,RC346-429 ,Diagnostic Assessment & Prognosis ,030304 developmental biology ,0303 health sciences ,neurodegeneration ,RC952-954.6 ,amyloid ,biomarkers ,Alzheimer's disease ,Psychiatry and Mental health ,Mexican American ,Geriatrics ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,Neuropsychological testing ,Psychology ,030217 neurology & neurosurgery ,Research Article - Abstract
Author(s): O'Bryant, Sid E; Johnson, Leigh A; Barber, Robert C; Braskie, Meredith N; Christian, Bradley; Hall, James R; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa; Philips, Nicole; Rissman, Robert A; Shi, Yonggang; Toga, Arthur W; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; HABLE Study Team | Abstract: IntroductionMexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health a Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.MethodsCommunity-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.ResultsData was examined from nn=n1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites.DiscussionThe current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.
- Published
- 2021