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4 results on '"Robinson, PD"'

1. Asthma and landscape fire smoke: A Thoracic Society of Australia and New Zealand position statement.

Author

McDonald, VM, Archbold, G, Beyene, T, Brew, BK, Franklin, P, Gibson, PG, Harrington, J, Hansbro, PM, Johnston, FH, Robinson, PD, Sutherland, M, Yates, D, Zosky, GR, Abramson, MJ, McDonald, VM, Archbold, G, Beyene, T, Brew, BK, Franklin, P, Gibson, PG, Harrington, J, Hansbro, PM, Johnston, FH, Robinson, PD, Sutherland, M, Yates, D, Zosky, GR, and Abramson, MJ

Abstract

Landscape fires are increasing in frequency and severity globally. In Australia, extreme bushfires cause a large and increasing health and socioeconomic burden for communities and governments. People with asthma are particularly vulnerable to the effects of landscape fire smoke (LFS) exposure. Here, we present a position statement from the Thoracic Society of Australia and New Zealand. Within this statement we provide a review of the impact of LFS on adults and children with asthma, highlighting the greater impact of LFS on vulnerable groups, particularly older people, pregnant women and Aboriginal and Torres Strait Islander peoples. We also highlight the development of asthma on the background of risk factors (smoking, occupation and atopy). Within this document we present advice for asthma management, smoke mitigation strategies and access to air quality information, that should be implemented during periods of LFS. We promote clinician awareness, and the implementation of public health messaging and preparation, especially for people with asthma.

Published
2023

2. Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

Author

Martins Costa Gomes, G, de Gouveia Belinelo, P, Starkey, MR, Murphy, VE, Hansbro, PM, Sly, PD, Robinson, PD, Karmaus, W, Gibson, PG, Mattes, J, and Collison, AM

Subjects
1107 Immunology, 1115 Pharmacology and Pharmaceutical Sciences
Abstract

Objective: Offspring born to mothers with asthma in pregnancy are known to have lower lung function which tracks with age. Human group 2 innate lymphoid cells (ILC2) accumulate in foetal lungs, at 10-fold higher levels compared to adult lungs. However, there are no data on foetal ILC2 numbers and the association with respiratory health outcomes such as lung function in early life. We aimed to investigate cord blood immune cell populations from babies born to mothers with asthma in pregnancy. Methods: Cord blood from babies born to asthmatic mothers was collected, and cells were stained in whole cord blood. Analyses were done using traditional gating approaches and computational methodologies (t-distributed stochastic neighbour embedding and PhenoGraph algorithms). At 6 weeks of age, the time to peak tidal expiratory flow as a percentage of total expiratory flow time (tPTEF/tE%) was determined as well as Lung Clearance Index (LCI), during quiet natural sleep. Results: Of 110 eligible infants (March 2017 to November 2019), 91 were successfully immunophenotyped (82.7%). Lung function was attempted in 61 infants (67.0%), and 43 of those infants (70.5% of attempted) had technically acceptable tPTEF/tE% measurements. Thirty-four infants (55.7% of attempted) had acceptable LCI measurements. Foetal ILC2 numbers with increased expression of chemoattractant receptor-homologous molecule (CRTh2), characterised by two distinct analysis methodologies, were associated with poorer infant lung function at 6 weeks of age." Conclusion: Foetal immune responses may be a surrogate variable for or directly influence lung function outcomes in early life.

Published
2021

4. Ehlers–Danlos syndrome and anorexia nervosa: a dangerous combination?

Author

Miles SC, Robinson PD, and Miles JL

Subjects
Adolescent, Anorexia Nervosa complications, Anorexia Nervosa diagnostic imaging, Bradycardia diagnosis, Bradycardia etiology, Ehlers-Danlos Syndrome complications, Ehlers-Danlos Syndrome diagnostic imaging, Humans, Male, Mediastinal Emphysema diagnosis, Mediastinal Emphysema etiology, Radiography, Thoracic, Anorexia Nervosa diagnosis, Ehlers-Danlos Syndrome diagnosis
Abstract

A 16-year-old boy with anorexia nervosa and Ehlers–Danlos syndrome presented with spontaneous pneumomediastinum and bradycardia.Although prior occurrences of pneumomediastinum and visceral perforations have been reported in adolescents with isolated anorexia nervosa or Ehlers–Danlos syndrome, to our knowledge this is the first instance to be noted in a patient with both conditions.We explore several possibilities regarding the etiology of his mediastinal air, but ultimately conclude that it was the existence of Ehlers–Danlos syndrome in the presence of anorexia nervosa that led to the development of this dangerous condition.

Published
2007
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