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Your search keyword '"Robert M. Cronin"' showing total 3 results
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3 results on '"Robert M. Cronin"'

2. Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT)

Author

Christian M. Shaffer, Simon Mallal, Rebecca Pavlos, Jason H. Karnes, Heidi E. Steiner, Dan M. Roden, Silvana Gaudieri, Robert M. Cronin, Ian James, Lisa Bastarache, Jonathan D. Mosley, Elizabeth J. Phillips, and Joshua C. Denny

Subjects
Adult, Male, 0301 basic medicine, Population, Immunogenetics, Human leukocyte antigen, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Receptors, KIR, HLA Antigens, Heparin-induced thrombocytopenia, Genotype, medicine, Humans, Pharmacology (medical), Allele, education, Alleles, Aged, Genetics, education.field_of_study, biology, Heparin, Anticoagulants, Odds ratio, Middle Aged, medicine.disease, Thrombocytopenia, 030104 developmental biology, Case-Control Studies, Immunology, biology.protein, Female, Antibody, Databases, Nucleic Acid
Abstract

Objectives Heparin-induced thrombocytopenia (HIT) is an unpredictable, life-threatening, immune-mediated reaction to heparin. Variation in human leukocyte antigen (HLA) genes is now used to prevent immune-mediated adverse drug reactions. Combinations of HLA alleles and killer cell immunoglobulin-like receptors (KIR) are associated with multiple autoimmune diseases and infections. The objective of this study is to evaluate the association of HLA alleles and KIR types, alone or in the presence of different HLA ligands, with HIT. Methods HIT cases and heparin-exposed controls were identified in BioVU, an electronic health record coupled to a DNA biobank. HLA sequencing and KIR type imputation using Illumina® OMNI-Quad data were performed. Odds ratios for HLA alleles and KIR types and HLA*KIR interactions using conditional logistic regressions were determined in the overall population and by race/ethnicity. Analysis was restricted to KIR types and HLA alleles with a frequency greater than 0.01. P values for HLA and KIR association were corrected using a false discovery rate (FDR) q

Published
2017
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3. Barriers and facilitators to research participation among adults, and parents of children with sickle cell disease: A trans-regional survey

Author

Marsha Treadwell, Patricia Adams-Graves, Michael R. DeBaun, Brandi L. McClain, Alexis A. Thompson, Adetola A. Kassim, Karen Kalinyak, Jeannie Byrd, Jane S. Hankins, and Robert M. Cronin

Subjects
Adult, Male, Parents, medicine.medical_specialty, Pediatrics, Adolescent, 020205 medical informatics, Anemia, MEDLINE, Anemia, Sickle Cell, 02 engineering and technology, Disease, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, 0202 electrical engineering, electronic engineering, information engineering, Humans, Medicine, 030212 general & internal medicine, Young adult, Child, Aged, business.industry, Research, Infant, Hematology, Middle Aged, medicine.disease, Child, Preschool, Family medicine, Female, business
Published
2016
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