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Background: The incidence of sedentary behaviour and cardiovascular disease impacts the health of older people, potentially leading to serious and negative health consequences., Aim: The purpose of this umbrella review was to identify the systematic reviews that explore the association between sedentary behaviour and cardiovascular disease specific to older people., Methods: An umbrella review was undertaken to systematically search five databases. Papers included were published between 2011 and 2015., Results: A search yielded 2,163 results. Six reviews met the inclusion criteria. While all six systematic reviews included older people in the overall sample, only one systematic review focused on an entirely older person population. Three of the six systematic reviews provided a meta-analysis, but none of the reviews reported a separate subgroup analysis for a discrete sample of older people CONCLUSION: This umbrella review demonstrates that while sedentary behaviour is associated with cardiovascular disease, a gap exists in the analysis on the relationship specific to older persons., Implications for Practice: Interventions aimed at reducing sedentary behaviour may improve cardiovascular health and well-being among older people., (© 2018 John Wiley & Sons Ltd.)

The URA3 gene of Candida utilis encoding orotidine-5'-phosphate decarboxylase enzyme was isolated by complementation in Escherichia coli pyrF mutation. The deduced amino-acid sequence is highly similar to that of the Ura3 proteins from other yeast and fungal species. An extensive analysis of the family of orotidine-5'-phosphate decarboxylase is shown. The URA3 gene of C. utilis was able to complement functionally the ura3 mutation of Saccharomyces cerevisiae.