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12 results on '"Ritchie, Stuart J."'

2. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age

Author

Wiseman, Stewart J., Booth, Tom, Ritchie, Stuart J., Cox, Simon R., Muñoz Maniega, Susana, Valdés Hernández, Maria del C., Dickie, David Alexander, Royle, Natalie A., Starr, John M., Deary, Ian J., Wardlaw, Joanna M., and Bastin, Mark E.

Abstract

Objective:\ud \ud To assess brain structural connectivity in relation to cognitive abilities in healthy ageing, and the mediating effects of white matter hyper‐intensity (WMH) volume.\ud Methods:\ud \ud MRI data were analysed in 558 members of the Lothian Birth Cohort 1936. Brains were segmented into 85 regions and combined with tractography to generate structural connectomes. WMH volume was quantified. Relationships between whole‐brain connectivity, assessed using graph theory metrics, and four major domains of cognitive ability (visuospatial reasoning, verbal memory, information processing speed and crystallized ability) were investigated, as was the mediating effects of WMH volume on these relationships.\ud Results:\ud \ud Visuospatial reasoning was associated with network strength, mean shortest path length, and global efficiency. Memory was not associated with any network connectivity metric. Information processing speed and crystallized ability were associated with all network measures. Some relationships were lost when adjusted for mean network FA. WMH volume mediated 11%–15% of the relationships between most network measures and information processing speed, even after adjusting for mean network FA.\ud Conclusion:\ud \ud Brain structural connectivity relates to visuospatial reasoning, information processing speed and crystallized ability, but not memory, in this relatively healthy age‐homogeneous cohort of 73 year olds. When adjusted for mean FA across the network, most relationships are lost, except with information processing speed suggesting that the underlying topological network structure is related to this cognitive domain. Moreover, the connectome‐processing speed relationship is partly mediated by WMH volume in this cohort.

Published
2018

3. Retinal microvascular features and cognitive change in the Lothian‐Birth Cohort 1936

Author

McGrory, Sarah, primary, Ballerini, Lucia, additional, Okely, Judith A., additional, Ritchie, Stuart J., additional, Doubal, Fergus N., additional, Doney, Alex S.F., additional, Dhillon, Baljean, additional, Starr, John M., additional, MacGillivray, Thomas J., additional, Trucco, Emanuele, additional, Wardlaw, Joanna M., additional, and Deary, Ian J., additional

Published
2019
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4. Coupled changes in hippocampal structure and cognitive ability in later life

Author

Anblagan, Devasuda, primary, Valdés Hernández, Maria C., additional, Ritchie, Stuart J., additional, Aribisala, Benjamin S., additional, Royle, Natalie A., additional, Hamilton, Iona F., additional, Cox, Simon R., additional, Gow, Alan J., additional, Pattie, Alison, additional, Corley, Janie, additional, Starr, John M., additional, Muñoz Maniega, Susana, additional, Bastin, Mark E., additional, Deary, Ian J., additional, and Wardlaw, Joanna M., additional

Published
2018
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5. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age

Author

Wiseman, Stewart J., primary, Booth, Tom, additional, Ritchie, Stuart J., additional, Cox, Simon R., additional, Muñoz Maniega, Susana, additional, Valdés Hernández, Maria del C., additional, Dickie, David Alexander, additional, Royle, Natalie A., additional, Starr, John M., additional, Deary, Ian J., additional, Wardlaw, Joanna M., additional, and Bastin, Mark E., additional

Published
2017
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9. Brain volumetric changes and cognitive ageing during the eighth decade of life

Author

Ritchie, Stuart J., primary, Dickie, David Alexander, additional, Cox, Simon R., additional, Valdes Hernandez, Maria del C., additional, Corley, Janie, additional, Royle, Natalie A., additional, Pattie, Alison, additional, Aribisala, Benjamin S., additional, Redmond, Paul, additional, Muñoz Maniega, Susana, additional, Taylor, Adele M., additional, Sibbett, Ruth, additional, Gow, Alan J., additional, Starr, John M., additional, Bastin, Mark E., additional, Wardlaw, Joanna M., additional, and Deary, Ian J., additional

Published
2015
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12. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age.

Author

Wiseman SJ, Booth T, Ritchie SJ, Cox SR, Muñoz Maniega S, Valdés Hernández MDC, Dickie DA, Royle NA, Starr JM, Deary IJ, Wardlaw JM, and Bastin ME

Subjects
Aged, Aging pathology, Brain anatomy & histology, Connectome, Female, Humans, Imaging, Three-Dimensional, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neural Pathways anatomy & histology, Neural Pathways diagnostic imaging, Neural Pathways physiology, Neuropsychological Tests, White Matter anatomy & histology, White Matter diagnostic imaging, White Matter physiology, Aging physiology, Aging psychology, Brain diagnostic imaging, Brain physiology, Mental Processes physiology
Abstract

Objective: To assess brain structural connectivity in relation to cognitive abilities in healthy ageing, and the mediating effects of white matter hyper-intensity (WMH) volume., Methods: MRI data were analysed in 558 members of the Lothian Birth Cohort 1936. Brains were segmented into 85 regions and combined with tractography to generate structural connectomes. WMH volume was quantified. Relationships between whole-brain connectivity, assessed using graph theory metrics, and four major domains of cognitive ability (visuospatial reasoning, verbal memory, information processing speed and crystallized ability) were investigated, as was the mediating effects of WMH volume on these relationships., Results: Visuospatial reasoning was associated with network strength, mean shortest path length, and global efficiency. Memory was not associated with any network connectivity metric. Information processing speed and crystallized ability were associated with all network measures. Some relationships were lost when adjusted for mean network FA. WMH volume mediated 11%-15% of the relationships between most network measures and information processing speed, even after adjusting for mean network FA., Conclusion: Brain structural connectivity relates to visuospatial reasoning, information processing speed and crystallized ability, but not memory, in this relatively healthy age-homogeneous cohort of 73 year olds. When adjusted for mean FA across the network, most relationships are lost, except with information processing speed suggesting that the underlying topological network structure is related to this cognitive domain. Moreover, the connectome-processing speed relationship is partly mediated by WMH volume in this cohort. Hum Brain Mapp 39:622-632, 2018. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc., (© 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.)

Published
2018
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