1. Musculin is highly enriched in Th17 and IL‐22‐producing ILC3s and restrains pro‐inflammatory cytokines in murine colitis
- Author
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Yang Cao, Jing Shao, Jun Yan, Wei Ma, Richard I. Near, Shunzong Yuan, Xuemei Zhong, Xue Yang, Huaping Liang, Yijia Liu, Changchuin Mao, Jing Yu, Wenda Gao, and Wan-Qi Tang
- Subjects
0301 basic medicine ,Immunology ,Mice, Transgenic ,Biology ,law.invention ,Proinflammatory cytokine ,Interleukin 22 ,03 medical and health sciences ,0302 clinical medicine ,Transcription (biology) ,law ,Basic Helix-Loop-Helix Transcription Factors ,medicine ,Animals ,Immunology and Allergy ,Murine colitis ,Lymphocytes ,Colitis ,Transcription factor ,Mice, Knockout ,Interleukins ,Dextran Sulfate ,Interleukin-17 ,medicine.disease ,Immunity, Innate ,Mice, Inbred C57BL ,030104 developmental biology ,Cancer research ,Cytokines ,Th17 Cells ,Suppressor ,Inflammation Mediators ,Antagonism ,030215 immunology - Abstract
Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC-/- mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC-/- mice by IL-22 antagonism suggests the existence of MSC:IL-22 regulatory axis.
- Published
- 2021