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Your search keyword '"Remling-Mulder, Leila"' showing total 9 results
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9 results on '"Remling-Mulder, Leila"'

4. Evolution of SIVmac239 following serial passaging in humanized mice

Author

Curlin, James Z., primary, Schmitt, Kimberly, additional, Remling‐Mulder, Leila, additional, Morrison, Jared, additional, Baczenas, John J., additional, Tibbits, Corina Valencia, additional, Goff, Kelly, additional, O'Connor, Shelby, additional, Stenglein, Mark, additional, Marx, Preston, additional, and Akkina, Ramesh, additional

Published
2022
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6. Evolution of SIVsm in humanized mice towards HIV‐2

Author

Curlin, James, primary, Schmitt, Kimberly, additional, Remling‐Mulder, Leila, additional, Moriarty, Ryan, additional, Goff, Kelly, additional, O’Connor, Shelby, additional, Stenglein, Mark, additional, Marx, Preston, additional, and Akkina, Ramesh, additional

Published
2020
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9. SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model.

Author

Curlin J, Schmitt K, Remling-Mulder L, Moriarty R, Stenglein M, O'Connor S, Marx P, and Akkina R

Subjects
Animals, Biological Evolution, HIV Infections veterinary, HIV Infections virology, HIV-1 genetics, Mice, Mice, Transgenic, Simian Acquired Immunodeficiency Syndrome virology, Simian Immunodeficiency Virus genetics, CD4 Lymphocyte Count, Evolution, Molecular, Genome, Viral, HIV-1 physiology, Simian Immunodeficiency Virus physiology, Viral Load
Abstract

HIV-1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross-species transmission. Increasing viral loads, CD4 + T-cell decline, and non-synonymous mutations were seen in the entire genome reflecting viral adaptation., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2020
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