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2 results on '"Raorao Zhou"'

1. High‐Speed Centrifugation Efficiently Removes Immunogenic Elements in Osteochondral Allografts

Author

Yongsheng Ma, Qitai Lin, Wenming Yang, Yang Liu, Yugang Xing, Zhiyuan Ren, Xueding Wang, Raorao Zhou, Gaige Wu, Pengcui Li, Wangping Duan, Xiaoling Zhang, and Xiaochun Wei

Subjects
Allografts, Articular Cartilage, Centrifugation, Immunogenic Elements, Pulse Lavage, Orthopedic surgery, RD701-811
Abstract

Objectives The current clinical pulse lavage technique for flushing fresh osteochondral allografts (OCAs) to remove immunogenic elements from the subchondral bone is ineffective. This study aimed to identify the optimal method for removing immunogenic elements from OCAs. Methods We examined five methods for the physical removal of immunogenic elements from OCAs from the femoral condyle of porcine knees. We distributed the OCAs randomly into the following seven groups: (1) control, (2) saline, (3) ultrasound, (4) vortex vibration (VV), (5) low‐pulse lavage (LPL), (6) high‐pulse lavage (HPL), and (7) high‐speed centrifugation (HSC). OCAs were evaluated using weight measurement, micro‐computed tomography (micro‐CT), macroscopic and histological evaluation, DNA quantification, and chondrocyte activity testing. Additionally, the subchondral bone was zoned to assess the bone marrow and nucleated cell contents. One‐way ANOVA and paired two‐tailed Student's t‐test are used for statistical analysis. Results Histological evaluation and DNA quantification showed no significant reduction in marrow elements compared to the control group after the OCAs were treated with saline, ultrasound, or VV treatments; however, there was a significant reduction in marrow elements after LPL, HPL, and HSC treatments. Furthermore, HSC more effectively reduced the marrow elements of OCAs in the middle and deep zones compared with LPL (p

Published
2024
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2. The influence of prostate volume on clinical parameters in prostate cancer screening

Author

Jiahao Shan, Xinyu Geng, Youlu Lu, Ziyang Liu, Hengyu Zhu, Raorao Zhou, Zhengyuan Zhang, Xianghui Gang, Duobing Zhang, and Hongbin Shi

Subjects
Male, Microbiology (medical), Biochemistry (medical), Clinical Biochemistry, Prostate, Prostatic Hyperplasia, Public Health, Environmental and Occupational Health, Prostatic Neoplasms, Hematology, Prostate-Specific Antigen, Medical Laboratory Technology, ROC Curve, Humans, Immunology and Allergy, Biomarkers, Early Detection of Cancer
Abstract

The purpose of the study was to evaluate the diagnostic significance of two new and a few clinical markers for prostate cancer (PCa) at various prostate volumes (PV).The study subjects were divided into two groups. Among them, there were 70 cases in the PV ≤30 ml group (benign prostatic hyperplasia [BPH]: 32 cases, PCa: 38 cases) and 372 cases in the PV 30 ml group (BPH: 277 cases, PCa: 95 cases). SPSS 26.0 and GraphPad Prism 8.0 were used to construct their receiver operating characteristic (ROC) curves for diagnosing PCa and calculating their area under the ROC curve (AUC).In the PV ≤30 ml group, the diagnostic parameters based on prostate-specific antigen (PSA) had a decreased diagnostic significance for PCa. In the PV 30 ml group, PSAD (AUC = 0.709), AVR (AVR = Age/PV, AUC = 0.742), and A-PSAD (A-PSAD = Age×PSA/PV, AUC = 0.736) exhibited moderate diagnostic significance for PCa, which was better than PSA-AV (AUC = 0.672), free PSA (FPSA, AUC = 0.509), total PSA (TPSA, AUC = 0.563), (F/T) PSA (AUC = 0.540), and (F/T)/PSAD (AUC = 0.663). Compared with AVR, A-PSAD exhibited similar diagnostic significance for PCa, but higher than PSA density (PSAD).Choosing appropriate indicators for different PVs could contribute to the early screening and diagnosis of PCa. The difference in the diagnostic value of two new indicators (A-PSAD and AVR), and PSAD for PCa may require further validation by increasing the sample size.

Published
2022

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