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Objectives To report the final results of the 2-year TAURUS study, assessing weekly prophylaxis dosing regimens of octocog alfa (Kovaltry (R)/BAY 81-8973) used in standard clinical practice in patients with moderate-to-severe haemophilia A. Methods TAURUS (NCT02830477) is a phase 4, multinational, prospective, non-interventional, single-arm study in patients of any age with moderate or severe haemophilia A (= 1

Oligochitosan (COS) and oligo-β-glucan (βOG) were prepared by gamma Co-60 irradiation of chitosan/H2O2 and β-glucan/H2O2 solutions. The striped catfish (P. hypophthalmus) was fed by diets containing 0 – 200 mg COS, βOG and mixture of COS/βOG per kg feed for 45 days, and then challenged with Edwardsiella ictaluri bacterium. The effects of supplemented COS, βOG and mixture of COS/βOG on immune stimulation and growth performance in striped catfish were investigated. The results indicated that striped catfish fed with 100 – 200 mg COS or βOG/kg feed, the growth performance was significantly improved and the mortality was considerably decreased. Furthermore, striped catfish fed with supplementation of 50 mg COS + 50 mg βOG/kg feed was the best for increasing weight gain (∼26%) and for decreasing mortality (∼38%) compared with control group. Moreover, phagocytic activity and lysozyme activity of fish were enhanced by feeding diet supplemented COS and/or βOG. Thus, COS and/or βOG can be potentially utilized as the immunostimulants and growth promoters for aquaculture. This article is protected by copyright. All rights reserved