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C-vinyl glycosides are an important class of carbohydrates and pose a unique synthetic challenge. A new strategy has been developed for stereoselective synthesis of C-vinyl glycosides via Pd-catalyzed directed C-H glycosylation of alkenes with glycosyl chloride donors using an easily removable bidentate auxiliary. Both the γ C-H bond of allylamines and the δ C-H bond of homoallyl amine substrates can be glycosylated in high efficiency and with excellent regio- and stereoselectivity. The resulting C-vinyl glycosides can be further converted to a variety of C-alkyl glycosides with high stereospecificity. These reactions offer a broadly applicable method to streamline the synthesis of complex C-vinyl glycosides from easily accessible starting materials.

Objective Chinese left-behind children have faced a high level of stress and tend to engage in nonsuicidal self-injury (NSSI) behavior. However, the impacts of parental migration on NSSI are complex. The improved family's socioeconomic status (SES) could have positive impacts on these children's mental health, yet the parental absence could have negative influences. To explore the complex dynamics of parental migration on NSSI, this study examined the roles of parent-child cohesion and SES in the relationship between stressful life events and NSSI. Method A total of 509 left-behind children completed self-report surveys that addressed stressful life events, NSSI, parent-child cohesion, and SES. Results Stressful life events were positively related to NSSI in both the migrant father and two migrant parents' groups. Furthermore, for children with migrant fathers, father-child cohesion and SES significantly moderated the relation between stressful life events and NSSI. The interaction of stressful life events, mother-child cohesion, and SES also was significant. For children with two migrant parents, mother-child cohesion was negatively related to NSSI. No significant interactions were found in this group. Conclusions The findings suggested that, although parent-child cohesion and SES were both important for the prevention of NSSI among left-behind children, parent-child cohesion should remain a priority.

This study aimed to investigate the phenomenon of mitochondrial apoptosis and autophagy in the process of adipose-derived stromal cell (ADSC) differentiation into astrocytes for 48 h, 7 days, 14 days, and 21 days. Immunocytochemistry and Western blotting indicated that the expression of GFAP reached a peak on the 7th day (P