Search

Your search keyword '"QUARANTA, L."' showing total 21 results
Start Over Author "QUARANTA, L." Publisher wiley
21 results on '"QUARANTA, L."'

20. Macular versus nerve fibre layer versus optic nerve head imaging for diagnosing glaucoma at different stages of the disease: Multicenter Italian Glaucoma Imaging Study

Author

Luciano Quaranta, E. Martini, Stefano Miglior, Manuele Michelessi, Michele Figus, Stefano Fazio, Paolo Frezzotti, Ivano Riva, Luca Agnifili, Chiara Posarelli, Francesco Oddone, Gianluca Manni, Michelessi, M, Riva, I, Martini, E, Figus, M, Frezzotti, P, Agnifili, L, Manni, G, Quaranta, L, Miglior, S, Posarelli, C, Fazio, S, and Oddone, F

Subjects
Male, Retinal Ganglion Cells, Visual acuity, genetic structures, Visual Acuity, Glaucoma, diagnostic accuracy, glaucoma, macular analysis, minimum rim width, optical coherence tomography, Nerve Fibers, 0302 clinical medicine, Macula Lutea, Prospective Studies, Prospective cohort study, Tomography, education.field_of_study, medicine.diagnostic_test, Incidence, General Medicine, Middle Aged, Visual field, Optic nerve, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Ophthalmoscopy, Optic Disk, Reproducibility of Results, Tomography, Optical Coherence, Visual Field Tests, medicine.symptom, medicine.medical_specialty, Population, 03 medical and health sciences, Optical coherence tomography, Settore MED/30, Ophthalmology, medicine, education, business.industry, medicine.disease, eye diseases, Optical Coherence, 030221 ophthalmology & optometry, sense organs, business, 030217 neurology & neurosurgery
Abstract

Purpose: To compare the diagnostic accuracy of minimum rim width (MRW), peripapillary retinal nerve fibre layer (pRNFL) and multilayered macular analysis by Spectralis SD-OCT (Heidelberg Engineering, Germany) in discriminating perimetric glaucoma at different stages of the disease from healthy eyes. Methods: In this multicentre, prospective, evaluation of diagnostic tests study, multilayered macular analysis and MRW and pRNFL were obtained from one eye of 197 glaucoma (76 early, 68 moderate and 53 advanced) and of 83 healthy controls from the Multicenter Italian Glaucoma Imaging Study (MIGIS). The reference standard for classifying eyes as glaucomatous and for staging thedisease was the visual field. The main outcome measures were area under the ROC curve (AUC) and sensitivity at fixed specificity (95%). Results: Average MRW and average pRNFL showed the highest and similar diagnostic accuracy in both the whole study population (AUC 0.968 and 0.939) and early glaucoma (AUC 0.956 and 0.929). Among the macular parameters, the three innermost retinal layers combined as the Ganglion Cell Complex provided the highest diagnostic accuracy (AUC 0.931) in the whole population, which was statistically similar to that of average pRNFL but inferior to that of average MRW. Compared to both average MRW and pRNFL, all macular parameters showed statistically significant lower accuracy in early glaucoma, but accuracy in moderate and advanced glaucoma showed no statistically significant differences among three protocols. Conclusion: The diagnostic accuracy of MRW, pRNFL and macular analysis by Spectralis SD-OCT is overall good. MRW and pRNFL analysis performs statistically and clinically better than macular analysis to discriminate early glaucoma from healthy eyes.

Published
2018

21. Circadian intraocular pressure and blood pressure reduction with timolol 0.5% solution and timogel 0.1% in patients with primary open-angle glaucoma.

Author

Quaranta L, Katsanos A, Floriani I, Riva I, Russo A, and Konstas AG

Subjects
Aged, Blood Pressure drug effects, Cross-Over Studies, Drug Administration Schedule, Female, Gels, Humans, Intraocular Pressure drug effects, Male, Middle Aged, Ophthalmic Solutions, Adrenergic beta-Antagonists administration & dosage, Antihypertensive Agents administration & dosage, Glaucoma, Open-Angle drug therapy, Timolol administration & dosage
Abstract

Purpose: To investigate the circadian and blood pressure (BP) reduction obtained with timolol maleate 0.5% solution administered twice daily versus timolol 0.1% in gel-forming carbomer administered in the morning in patients with primary open-angle glaucoma (POAG)., Methods: This investigator-masked, crossover study prospectively enrolled naive POAG patients not receiving systemic cardiovascular medications. Following a baseline evaluation, they were randomized to receive a timolol 0.5% solution or timolol 0.1% hydrogel for 2 months and then switched to the alternative medication for a further 2 months. Intraocular pressure (IOP) phasing (sitting Goldmann tonometry at 10 am, 2 pm, 6 pm, and 10 pm and supine Perkins tonometry at 2 am and 6 am) and ambulatory home BP monitoring were measured at baseline and after each treatment period., Results: On the basis of a prospective sample size estimate, 28 patients were analyzed. Mean 24-hour IOP decreased from 23.1 ± 0.7 mm Hg at baseline to 18.9 ± 0.6 mm Hg after timolol 0.5% and 18.9 ± 0.8 mm Hg after timolol 0.1% hydrogel (P < .001); both formulations also significantly decreased diurnal, nocturnal, and individual time point IOP in a statistically similar manner. Systolic and diastolic BP remained generally unaffected. The calculated diastolic ocular perfusion pressure was either unaffected or tended to increase with either medication., Conclusion: Both timolol formulations show similar and significant circadian efficacy and have minimal effects on BP and calculated diastolic ocular perfusion pressure.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results