1. Orbital granulocytic sarcomas (myeloid sarcomas) in acute nonlymphocytic leukemia.
- Author
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Shome DK, Gupta NK, Prajapati NC, Raju GM, Choudhury P, and Dubey AP
- Subjects
- Adolescent, Child, Child, Preschool, Exophthalmos etiology, Female, Granulocytes pathology, Humans, Immunophenotyping, Macrophages pathology, Male, Monocytes pathology, Leukemia, Myeloid pathology, Leukemia, Myeloid, Acute pathology, Neoplasms, Multiple Primary pathology, Orbital Neoplasms pathology
- Abstract
In a series of 89 patients with acute leukemia, orbital granulocytic sarcomas were observed in 7. All these patients had acute nonlymphocytic leukemia, and they were all children. The orbital involvement usually was bilateral, and the patients had proptosis, conjunctival hemorrhage, and chemosis. Morphologic, cytochemical, and immunophenotypic analyses did not show a predilection for any particular myeloid cell type. Two patients had biphenotypic leukemias with myeloid components. The ocular manifestations responded well to chemotherapy irrespective of the hematologic response.
- Published
- 1992
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