1. Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study
- Author
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Steven Jacobson, Tianxia Wu, Avindra Nath, Pascal Sati, Vincent Van Pesch, Daniel S. Reich, Marie Théaudin, Irene Cortese, Caroline Pot, Massimo Filippi, Vittorio Martinelli, Peter A. Calabresi, Renaud Du Pasquier, M. Absinta, Pietro Maggi, Govind Nair, Roberta Scotti, Gaetano Perrotta, Bryan Smith, Joan Ohayon, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, Maggi, Pietro, Sati, Pascal, Nair, Govind, Cortese, Irene C M, Jacobson, Steven, Smith, Bryan R, Nath, Avindra, Ohayon, Joan, van Pesch, Vincent, Perrotta, Gaetano, Pot, Caroline, Théaudin, Marie, Martinelli, Vittorio, Scotti, Roberta, Wu, Tianxia, Du Pasquier, Renaud, Calabresi, Peter A, Filippi, Massimo, Reich, Daniel S, and Absinta, Martina
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,Neuroimaging ,Sensitivity and Specificity ,Article ,Diagnosis, Differential ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,medicine ,Humans ,Diagnostic biomarker ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,Chronic Active ,business.industry ,Multiple sclerosis ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Clinical disease ,Magnetic Resonance Imaging ,Hyperintensity ,030104 developmental biology ,Neurology ,Female ,Neurology (clinical) ,Nervous System Diseases ,Differential diagnosis ,business ,030217 neurology & neurosurgery - Abstract
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034-1042.
- Published
- 2020