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Your search keyword '"Phipps, Simon"' showing total 21 results
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21 results on '"Phipps, Simon"'

2. Diagnostic evaluation of upper tract urothelial carcinoma: can we safely omit diagnostic ureteroscopy?

Author

Trail, Matthew, primary, Rahman, Muhammad Sajid Waheed, additional, Broadhurst, William J., additional, Blackmur, James P., additional, Sharma, Abhishek, additional, Chew, Etienne, additional, O'Donnell, Marie, additional, Keanie, Julian Y., additional, Brush, John, additional, Taylor, John, additional, Phipps, Simon, additional, Thomas, Ben, additional, Mains, Edward A.A., additional, McNeill, S. Alan, additional, Leung, Steve, additional, Cutress, Mark L., additional, and Laird, Alexander, additional

Published
2023
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3. RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

Author

Allam, Venkata Sita Rama Raju, primary, Faiz, Alen, additional, Lam, Maggie, additional, Rathnayake, Senani N. H., additional, Ditz, Benedikt, additional, Pouwels, Simon D., additional, Brandsma, Corry‐Anke, additional, Timens, Wim, additional, Hiemstra, Pieter S., additional, Tew, Gaik W., additional, Neighbors, Margaret, additional, Grimbaldeston, Michele, additional, van den Berge, Maarten, additional, Donnelly, Sheila, additional, Phipps, Simon, additional, Bourke, Jane E., additional, and Sukkar, Maria B., additional

Published
2020
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4. PAG1 limits allergen‐induced type 2 inflammation in the murine lung

Author

Ullah, Md Ashik, primary, Vicente, Cristina T., additional, Collinson, Natasha, additional, Curren, Bodie, additional, Sikder, Md Al Amin, additional, Sebina, Ismail, additional, Simpson, Jennifer, additional, Varelias, Antiopi, additional, Lindquist, Jonathan A., additional, Ferreira, Manuel A. R., additional, and Phipps, Simon, additional

Published
2019
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5. Prostate Benign Prostatic Hyperplasia

Author

Good, Daniel W., primary, Nahas, Bashar, additional, Phipps, Simon, additional, Popert, Rick, additional, Stolzenburg, Jens‐Uwe, additional, and McNeill, Stuart Alan S., additional

Published
2019
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8. Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation

Author

Poon, Ivan K. H., primary, Goodall, Katharine J., additional, Phipps, Simon, additional, Chow, Jenny D. Y., additional, Pagler, Eloisa B., additional, Andrews, Daniel M., additional, Conlan, Carly L., additional, Ryan, Gemma F., additional, White, Julie A., additional, Wong, Michael K. L., additional, Horan, Catherine, additional, Matthaei, Klaus I., additional, Smyth, Mark J., additional, and Hulett, Mark D., additional

Published
2014
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11. RAGE: a new frontier in chronic airways disease

Author

Sukkar, Maria B, primary, Ullah, Md Ashik, additional, Gan, Wan Jun, additional, Wark, Peter AB, additional, Chung, Kian Fan, additional, Hughes, J Margaret, additional, Armour, Carol L, additional, and Phipps, Simon, additional

Published
2012
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21. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.

Author

Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, and Ramshaw IA

Subjects
Animals, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes metabolism, Cell Line, Chlorocebus aethiops, Cytokines metabolism, Ectromelia virus physiology, Ectromelia, Infectious immunology, Ectromelia, Infectious prevention & control, Female, Gene Expression Regulation, Viral, Genetic Vectors genetics, Genetic Vectors metabolism, Humans, Interferon-beta genetics, Interferon-beta metabolism, Interleukin-12 metabolism, Interleukin-2 metabolism, Killer Cells, Natural immunology, Killer Cells, Natural metabolism, Lymphocyte Activation immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Virus Replication immunology, Cytokines genetics, Myeloid Differentiation Factor 88 genetics, Toll-Like Receptors genetics, Vaccinia virus genetics, Vaccinia virus metabolism
Abstract

Using Toll-like receptor (TLR) and MyD88 gene knock-out (GKO) mice the effect of TLRs and MyD88 on virus replication, interferon (IFN)-β production, natural killer (NK) cell and CD8T cell responses were assessed following ectromelia virus (ECTV) and recombinant vaccinia virus (rVV) infection. The capacity for rVVs encoding cytokines to restore immune function in MyD88(-/-) mice was clearly demonstrated. Results showed that TLR2(-/-), TLR4(-/-)and TLR7(-/-) mice survived ECTV infection whereas MyD88(-/-) and TLR9(-/-)mice, in contrast, were highly susceptible. Next, following infection with rVV, MyD88(-/-) mice elicited reduced serum IFN-β, NK cell and CD8T cell responses compared with wild-type mice, whereas TLR9(-/-) mice showed elevated CD8T cell responses. When MyD88(-/-)mice were infected with rVV co-expressing IFN-β these mice were able to restore IFN-β levels and CD8T cell responses but not NK cell activation. Interestingly, even though rVV co-expressing interleukin (IL)-2 enhanced NK cell activation in MyD88(-/-) mice, this was not associated with an antiviral effect, as observed in normal mice. Surprisingly, co-infection with rVV IL-2/rVV IL-12, but not rVV IL-2/rVV IFN-β, restored the attenuated phenotype of rVV IL-2 in MyD88(-/-) mice indicating that the IL-2/IL-12 combination promotes antiviral responses. Our results clearly show that the CD8T cell defect observed in MyD88(-/-) mice to vaccinia virus infection can be restored by rVV-encoding IFN-β demonstrating the critical role of this cytokine in T cell mediated immunity and illustrates that the model can provide an effective platform for the elucidation of cytokine immunobiology.

Published
2011
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