1. Organocatalytic Stereoselective α-Formylation of Ketones
- Author
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Montse Guiteras Capdevila, Pier Giorgio Cozzi, Enrico Emer, Stefano Grilli, Diego Petruzziello, Andrea Gualandi, Capdevila, M G, Emer, E, Gualandi, A, Petruzziello, D, Grilli, S, and Cozzi, P G
- Subjects
010405 organic chemistry ,Chemistry ,Stereochemistry ,Organic Chemistry ,Enantioselective synthesis ,organocatalysi ,010402 general chemistry ,STEREOSELECTIVITY ,01 natural sciences ,Catalysis ,3. Good health ,0104 chemical sciences ,Formylation ,Inorganic Chemistry ,Organocatalysis ,Organic chemistry ,Stereoselectivity ,Physical and Theoretical Chemistry - Abstract
We have described the first organocatalytic stereoselective formylation of ketones accomplished by the use of N-methybenzothiazolylium iodide. The benzothiazolium salt, generally used as a masked formyl group or as precursor of carbenes,[31] is quite electrophilic and react with enamines formed in situ. Both moderate yield and high stereoselectivity were obtained with different ketones.
- Published
- 2012
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