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13 results on '"Perrone Laura"'

1. Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children

Author

Menale, Ciro, primary, Grandone, Anna, additional, Nicolucci, Carla, additional, Cirillo, Grazia, additional, Crispi, Stefania, additional, Di Sessa, Anna, additional, Marzuillo, Pierluigi, additional, Rossi, Sergio, additional, Mita, Damiano Gustavo, additional, Perrone, Laura, additional, Diano, Nadia, additional, and Miraglia Del Giudice, Emanuele, additional

Published
2016
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6. Familial trisomy 6p in mother and daughter

Author

Savarese, Marco, primary, Grandone, Anna, additional, Perone, Lucia, additional, Blanco, Francesca Del Vecchio, additional, De Luca, Giuseppina, additional, Di Fruscio, Giuseppina, additional, Fogu, Giuseppina, additional, Piluso, Giulio, additional, Perrone, Laura, additional, del Giudice, Emanuele Miraglia, additional, and Nigro, Vincenzo, additional

Published
2013
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12. Low-protein diet and progression of retinal degeneration in gyrate atrophy of the choroid and retina: A twenty-six-year follow-up

Author

Ciro Costagliola, Laura Perrone, Francesco Prisco, Raffaele Santinelli, Angelo D'Avanzo, Carlo Tolone, A. D'Aloia, E. Miraglia del Giudice, Santinelli, R., Costagliola, C., Tolone, Carlo, D'Aloia, A., D'Avanzo, A., Prisco, F., Perrone, Laura, MIRAGLIA DEL GIUDICE, Emanuele, Santinelli, R, Costagliola, Ciro, Tolone, C, D'Aloia, A, D'Avanzo, A, Prisco, F, Perrone, L, and DEL GIUDICE, Em

Subjects
Adult, Ornithine, Retinal degeneration, medicine.medical_specialty, Arginine, medicine.medical_treatment, Biology, Retina, chemistry.chemical_compound, Atrophy, Low-protein diet, Internal medicine, Diet, Protein-Restricted, Genetics, medicine, Humans, gyrate atrophy, Genetics (clinical), Ornithine-Oxo-Acid Transaminase, Choroid, chorioretinal dystrophy, Homozygote, Retinal Degeneration, low-protein diet, Retinal, medicine.disease, Electrooculography, medicine.anatomical_structure, Endocrinology, chemistry, Child, Preschool, Female, Visual Fields, Follow-Up Studies
Abstract

Summary: Gyrate atrophy of the choroid and retina is an autosomal recessive chorioretinal dystrophy which leads to a slowly progressive loss of vision. The primary defect is due to a deficiency of the enzyme ornithine δ-aminotransferase, which is responsible for markedly elevated levels of ornithine in plasma and other body fluids. Although several therapeutic regimens have been proposed, the reduction in ornithine accumulation obtained by reducing the intake of its precursor arginine (semisynthetic low-arginine diet) is the one most practised. In this clinical and molecular study we report a patient with hyperornithinaemia and gyrate atrophy of the choroid and retina who had been diagnosed when she was 3 years 9 months old. She also presented mild mental retardation, delayed language development and speech defects. The patient has recently been found to be homozygous for the new Gly91Arg amino acid substitution of the enzyme ornithine δ-aminotransferase. This mutation lies in a region of the mature protein that is considered crucial for the mitochondrial targeting activity. In this patient, a 28-year treatment with a completely natural low-protein diet (0.8 g/kg per day of natural protein) has been able to significantly reduce ornithine plasma levels, and to greatly delay the natural progression of the chorioretinal changes. This study suggests that, in the long-term treatment of gyrate atrophy, the efficacy in slowing the progression of chorioretinal changes and the palatability of a completely natural low-protein diet make this treatment a potentially viable alternative in patients refusing the semisynthetic diet.

Published
2004
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13. Zinc and Copper Status of Allergic Children

Author

M. Miraglia del Giudice, G. Gialanella, R. Di Toro, R. Moro, L. Perrone, M. Galdo Capotorti, DI TORO, R, GALDO CAPOTORTI, G, Gialanella, G, MIRAGLIA DEL GIUDICE, Michele, Moro, R, and Perrone, Laura

Subjects
Male, Zinc level, Adolescent, Serum protein, chemistry.chemical_element, Physiology, Zinc, Dermatitis, Atopic, Humans, Medicine, Child, biology, business.industry, Albumin, Infant, Nutritional status, Feeding Behavior, General Medicine, medicine.disease, Copper, Asthma, chemistry, Child, Preschool, Pediatrics, Perinatology and Child Health, Immunology, Zinc deficiency, biology.protein, Female, business, Ceruloplasmin
Abstract

Zinc and copper status was examined in 19 healthy and 43 atopic children (22 asthmatics and 21 eczematous) 2-14 years old. Dietary intakes for energy, protein, zinc and copper and some nutritional indices (height, weight, serum protein, albumin, ceruloplasmin) were similar in the allergic and in the control group. The proton-induced X-ray fluorescence technique was used to assess zinc and copper concentrations in serum and hair. No difference was detected in serum zinc concentration between allergic and healthy children. In contrast, mean hair zinc level was lower (p less than 0.05) in allergic than in healthy children (99 +/- 6 vs. 147 +/- 9 micrograms/g). Mean serum copper content was higher in asthmatic than in control children while mean hair copper was higher (p less than 0.05) in asthmatic and eczematous children than in the control group. These findings suggest a different zinc and copper nutritional status between allergic and healthy subjects. Allergic children, in particular, seem to be a risk of zinc deficiency.

Published
1987
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