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20 results on '"Pei, Xuetao"'

1. Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells

Author

Wang, Xiaoling, primary, Zhang, Wei, additional, Zhao, Siqi, additional, Yan, Hao, additional, Xin, Zijuan, additional, Cui, Tiantian, additional, Zang, Ruge, additional, Zhao, Lingping, additional, Wang, Haiyang, additional, Zhou, Junnian, additional, Li, Xuan, additional, Yue, Wen, additional, Xi, Jiafei, additional, Zhang, Zhaojun, additional, Fang, Xiangdong, additional, and Pei, Xuetao, additional

Published
2024
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2. Generation of Rh D‐negative blood using CRISPR / Cas9

Author

Xu, Lei, primary, Zeng, Quan, additional, Liang, Liqing, additional, Yang, Zhou, additional, Qu, Mingyi, additional, Li, Huilin, additional, Zhang, Bowen, additional, Zhang, Jing, additional, Yuan, Xin, additional, Chen, Lin, additional, Fan, Zeng, additional, He, Lijuan, additional, Nan, Xue, additional, Yue, Wen, additional, Xie, Xiaoyan, additional, and Pei, Xuetao, additional

Published
2023
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3. Baffled‐flow culture system enables the mass production of megakaryocytes from human embryonic stem cells by enhancing mitochondrial function

Author

Wu, Xumin, primary, Zhang, Bowen, additional, Chen, Keyi, additional, Zhao, Jiahui, additional, Li, Yunxing, additional, Li, Jisheng, additional, Liu, Chuanli, additional, He, Lijuan, additional, Fan, Tao, additional, Wang, Chao, additional, Li, Yan, additional, Pei, Xuetao, additional, and Li, Yanhua, additional

Published
2023
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5. Therapeutic use of red blood cells and platelets derived from human cord blood stem cells

Author

Hailei Yao, Pei Xuetao, Xiaoyan Han, Xie Xiaoyan, and Wen Yue

Subjects
Blood Platelets, Medicine (General), Erythrocytes, Blood transfusion, medicine.medical_treatment, cord blood hematopoietic stem/progenitor cells, Antigens, CD34, Pharmacology, Concise Reviews, clinical translation, Blood cell, R5-920, megakaryocytes, medicine, Humans, Platelet, Progenitor cell, Cells, Cultured, QH573-671, Concise Review, business.industry, Cell Differentiation, Cell Biology, General Medicine, differentiation, Fetal Blood, Hematopoietic Stem Cells, Haematopoiesis, medicine.anatomical_structure, Hematopoietic Stem/Progenitor Cells, Cord blood, platelets, Stem cell, business, Cytology, Ex vivo, Developmental Biology, red blood cells
Abstract

Red blood cells (RBCs) and platelets derived from stem cells are possible solutions to the increasing demand for blood transfusion. Based on the availability of stem cells, their relatively defined differentiation mechanisms, and the massive exploration of induction systems, the generation of RBCs or platelets in vitro from cord blood hematopoietic stem/progenitor cells (CB‐HSPCs) has potential for clinical applications. However, information on the clinical translation of stem cell‐derived RBCs and platelets in the literature and at the ClinicalTrials.gov website is very limited. The only clinical trial on cultured RBCs, which aimed to assess the lifespan of RBCs cultured in vivo, was reported by Luc Douay and colleagues. Of note, the cultured RBCs they used were derived from autologous peripheral blood HSPCs, and no cultured platelets have been applied clinically to date. However, CB‐HSPC‐derived megakaryocytes, platelet precursors, have been used in the treatment of thrombocytopenia. A successful phase I trial was reported, followed by phase II and III clinical trials conducted in China. In this review, the gap between the many basic studies and limited clinical trials on stem cell‐derived RBCs and platelets is summarized. The possible reasons and solutions for this gap are discussed. Further technological improvements for blood cell expansion and maturation ex vivo and the establishment of biological standards for stem cell derivatives might help to facilitate the therapeutic applications of cultured RBCs and platelets derived from CB‐HSPCs in the near future., We review the progress in producing red blood cells (RBCs) and platelets from human cord blood hematopoietic stem/progenitor cells (HSPCs) and relatively limited reports on the clinical trials with cultured RBCs and megakaryocytic progenitors (MPs). Technical improvement together with the establishment of biological standards for stem cell derivations might help to achieve therapeutic applications of cultured RBCs and platelets. EPCs, erythroid progenitor cells.

Published
2021

6. Requirements for human haematopoietic stem/progenitor cells

Author

Nan, Xue, primary, Zhang, Bowen, additional, Hao, Jie, additional, Yue, Wen, additional, Fu, Boqiang, additional, Qu, Mingyi, additional, Zhang, Yu, additional, Wang, Haiyang, additional, Fang, Fang, additional, Wei, Jun, additional, Li, Qiyuan, additional, Hu, Shijun, additional, Yu, Junying, additional, Gao, Yingdai, additional, Liu, Qifa, additional, Cao, Jiani, additional, Wang, Lei, additional, Peng, Yaojin, additional, Zhu, Huanxin, additional, Liang, Lingmin, additional, Ma, Aijin, additional, Zhou, Jiaxi, additional, Zhao, Tongbiao, additional, and Pei, Xuetao, additional

Published
2021
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8. Requirements for human cardiomyocytes

Author

Yu, Miao, primary, Lei, Wei, additional, Cao, Jiani, additional, Wang, Lei, additional, Ma, Aijin, additional, Zhao, Zhen‐Ao, additional, Yang, Huang‐Tian, additional, Shen, Zhenya, additional, Lan, Feng, additional, Cao, Feng, additional, Liang, Ping, additional, Pei, Xuetao, additional, Xiang, Andy Peng, additional, Yu, Junying, additional, Zhang, Yu, additional, Zhang, Yong, additional, Li, Qiyuan, additional, Zhou, Jiaxi, additional, Wei, Jun, additional, Peng, Yaojin, additional, Zhu, Huanxin, additional, Liang, Lingmin, additional, Cao, Nan, additional, Fu, Boqiang, additional, Hao, Jie, additional, Zhao, Tongbiao, additional, and Hu, Shijun, additional

Published
2021
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9. Large‐scale generation of megakaryocytes from human embryonic stem cells using transgene‐free and stepwise defined suspension culture conditions

Author

Zhang, Bowen, primary, Wu, Xumin, additional, Zi, Guicheng, additional, He, Lijuan, additional, Wang, Sihan, additional, Chen, Lin, additional, Fan, Zeng, additional, Nan, Xue, additional, Xi, Jiafei, additional, Yue, Wen, additional, Wang, Lei, additional, Wang, Liu, additional, Hao, Jie, additional, Pei, Xuetao, additional, and Li, Yanhua, additional

Published
2021
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11. General requirements for stem cells

Author

Hao, Jie, primary, Ma, Aijin, additional, Wang, Lei, additional, Cao, Jiani, additional, Chen, Si, additional, Wang, Liu, additional, Fu, Boqiang, additional, Zhou, Jiaxi, additional, Pei, Xuetao, additional, Zhang, Yu, additional, Xiang, Peng, additional, Hu, Shijun, additional, Li, Qiyuan, additional, Zhang, Yong, additional, Xia, Yingjie, additional, Zhu, Huanxin, additional, Stacey, Glyn, additional, Zhou, Qi, additional, and Zhao, Tongbiao, additional

Published
2020
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12. Requirements for human embryonic stem cells

Author

Hao, Jie, primary, Cao, Jiani, additional, Wang, Lei, additional, Ma, Aijin, additional, Chen, Si, additional, Ding, Jinfeng, additional, Wang, Liu, additional, Fu, Boqiang, additional, Zhang, Yu, additional, Pei, Xuetao, additional, Xiang, Peng, additional, Li, Qiyuan, additional, Zhang, Yong, additional, Zhou, Jiaxi, additional, Hu, Shijun, additional, Yu, Junying, additional, Wei, Jun, additional, Zhu, Huanxin, additional, Stacey, Glyn, additional, Zhao, Tongbiao, additional, and Zhou, Qi, additional

Published
2020
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13. HGF Mediates Clinical‐Grade Human Umbilical Cord‐Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence‐Accelerated Mouse Model of Alzheimer's Disease

Author

Jia, Yali, primary, Cao, Ning, additional, Zhai, Jinglei, additional, Zeng, Quan, additional, Zheng, Pei, additional, Su, Ruyu, additional, Liao, Tuling, additional, Liu, Jiajing, additional, Pei, Haiyun, additional, Fan, Zeng, additional, Zhou, Junnian, additional, Xi, Jiafei, additional, He, Lijuan, additional, Chen, Lin, additional, Nan, Xue, additional, Yue, Wen, additional, and Pei, Xuetao, additional

Published
2020
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14. Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression

Author

Liu, Yiming, primary, Ding, Li, additional, Zhang, Bowen, additional, Deng, Ziliang, additional, Han, Yi, additional, Wang, Sihan, additional, Yang, Shu, additional, Fan, Zeng, additional, Zhang, Jing, additional, Yan, Hongmin, additional, Han, Dongmei, additional, He, Lijuan, additional, Yue, Wen, additional, Wang, Hengxiang, additional, Li, Yanhua, additional, and Pei, Xuetao, additional

Published
2020
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