1. Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia
- Author
-
Craig L. Hyde, Xiaoming Du, Laura M. Rowland, Zhiyong Xie, Baohong Zhang, Sara A. Paciga, Patricio O'Donnell, Christian R. Schubert, Xing Chen, L. E. Hong, Christopher D. Whelan, Seth A. Ament, Peter Kochunov, Heather Bruce, Dinesh Shukla, Hugh O'Neill, Alfredo Bellon, and Hualin Xi
- Subjects
0301 basic medicine ,Genetics ,education.field_of_study ,Imaging genetics ,Population ,Genome-wide association study ,medicine.disease ,White matter ,03 medical and health sciences ,Behavioral Neuroscience ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Neurology ,Schizophrenia ,Endophenotype ,Fractional anisotropy ,medicine ,education ,Psychology ,Neuroscience ,030217 neurology & neurosurgery ,Psychiatric genetics - Abstract
Patients with schizophrenia show decreased processing speed on neuropsychological testing and decreased white matter integrity as measured by diffusion tensor imaging, two traits shown to be both heritable and genetically associated indicating that there may be genes that influence both traits as well as schizophrenia disease risk. The potassium channel gene family is a reasonable candidate to harbor such a gene given the prominent role potassium channels play in the central nervous system in signal transduction, particularly in myelinated axons. We genotyped members of the large potassium channel gene family focusing on putatively functional single nucleotide polymorphisms (SNPs) in a population of 363 controls, 194 patients with schizophrenia spectrum disorder (SSD) and 28 patients with affective disorders with psychotic features who completed imaging and neuropsychological testing. We then performed three association analyses using three phenotypes - processing speed, whole-brain white matter fractional anisotropy (FA) and schizophrenia spectrum diagnosis. We extracted SNPs showing an association at a nominal P value of
- Published
- 2017