144 results on '"Pathmanathan A"'
Search Results
2. Analysis and design for constant current/constant voltage multi‐coil wireless power transfer system with high EMF reduction
- Author
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Zhichao Luo, Mehanathan Pathmanathan, Wei Han, Shuang Nie, and Peter W. Lehn
- Subjects
Electronics ,TK7800-8360 - Abstract
Abstract The investigation on the constant current (CC)/constant voltage (CV) charging for the electric vehicle wireless power transfer (WPT) system has been widely conducted. However, the CC/CV performance under misalignment cases has been scarcely studied especially for the multi‐coil WPT system. The resonant tank compensation methodology for the exciter‐quadrature‐repeaters (EQR) transmitter‐based multi‐coil WPT system is studied to achieve high power factor CC/CV charging with low leakage flux over ±150 mm lateral misalignment range. The EQR transmitter consists of one small exciter coil powered by a single full bridge inverter and two larger decoupled quadrature repeater coils which are magnetically coupled to the exciter coil. A variable switched capacitor is applied on the exciter side to maintain a high power factor in the CV mode. A 3‐kW experimental setup with a 200 mm nominal vertical distance was built and a three‐coil WPT system with a single large repeater coil is chosen as a comparison. Experimental results show that the EQR transmitter‐based WPT system achieves 92% coil‐to‐coil efficiency and reduces the leakage flux density by 70% compared with the existing three‐coil system in the CV mode at 150‐mm lateral misalignment.
- Published
- 2022
- Full Text
- View/download PDF
3. Hyperarousal features in the sleep architecture of individuals with and without insomnia
- Author
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Di Marco, Tobias, primary, Scammell, Thomas E., additional, Sadeghi, Kolia, additional, Datta, Alexandre N., additional, Little, David, additional, Tjiptarto, Nurkurniati, additional, Djonlagic, Ina, additional, Olivieri, Antonio, additional, Zammit, Gary, additional, Krystal, Andrew, additional, Pathmanathan, Jay, additional, Donoghue, Jacob, additional, Hubbard, Jeffrey, additional, and Dauvilliers, Yves, additional
- Published
- 2024
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4. Evaluation framework for systems models
- Author
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Sietse Braakman, Pras Pathmanathan, and Helen Moore
- Subjects
Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract As decisions in drug development increasingly rely on predictions from mechanistic systems models, assessing the predictive capability of such models is becoming more important. Several frameworks for the development of quantitative systems pharmacology (QSP) models have been proposed. In this paper, we add to this body of work with a framework that focuses on the appropriate use of qualitative and quantitative model evaluation methods. We provide details and references for those wishing to apply these methods, which include sensitivity and identifiability analyses, as well as concepts such as validation and uncertainty quantification. Many of these methods have been used successfully in other fields, but are not as common in QSP modeling. We illustrate how to apply these methods to evaluate QSP models, and propose methods to use in two case studies. We also share examples of misleading results when inappropriate analyses are used.
- Published
- 2022
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5. Open‐phase fault tolerant driving operation of dual‐inverter‐based traction drive
- Author
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M. Pathmanathan, C.C.D. Viana, S. Semsar, and P.W. Lehn
- Subjects
Applications of electric power ,TK4001-4102 - Abstract
Abstract A method for achieving open‐phase fault tolerant operation of a dual‐inverter‐based traction drive with charging capability is presented. This method utilises a contactor to connect the switching nodes of the two half bridges which are normally used for AC charging in this dual inverter configuration. These half bridges are then modulated to provide a path for zero‐sequence current and enhance the available voltage vector space of the drive by injecting a controllable common‐mode voltage between the two inverters. A control method and five‐level modulator based on zero‐sequence voltage control and phase shifted carriers are introduced to accommodate this novel remedial method. Using this approach, the open‐phase faulted dual inverter drive is able to operate with twice the speed range of the conventional open‐phase fault tolerant approach, which is to provide a path for zero‐sequence current by connecting the negative DC rails of the two inverters with a contactor. Simulation and experimental results with a prototype dual inverter drive are presented to validate the theory of the new control and modulation method. The experimental results showcase the proposed algorithms performance by dynamically responding to an open‐phase fault and starting from standstill, thereby proving its validity for an electric vehicle application.
- Published
- 2021
- Full Text
- View/download PDF
6. Field orientation based three‐coil decoupled wireless transmitter for electric vehicle charging with large lateral receiver misalignment tolerance
- Author
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Shuang Nie, Mehanathan Pathmanathan, Netan Yakop, Zhichao Luo, and Peter W. Lehn
- Subjects
Power electronics, supply and supervisory circuits ,Inductors and transformers ,Other power apparatus and electric machines ,Transportation ,DC‐AC power convertors (invertors) ,Wireless power transmission ,Electronics ,TK7800-8360 - Abstract
Abstract A three‐coil decoupled transmitter is developed for the inductive power transfer system of electric vehicle charging. The three‐coil decoupled transmitter consists of three overlapping rectangular coils with magnetic mutual decoupling and is capable of overcoming large receiver lateral misalignment up to 20 cm. A current optimization method is advanced to derive transmitter coil currents for the multi‐phase system that minimizes the coil loss through optimizing the current distribution among transmitter coils. The optimized current distribution reduces the maximum leakage flux by around 40% compared to the best alternative excitation method. The compensation strategy provides unity power factor for high‐power transfer phases and allows a single set of compensation capacitors to be used regardless of receiver alignment. The three‐coil decoupled transmitter is compatible with a typical three‐phase inverter for industrial practical application, which halves the power electronic switches used with previous topologies. The simulation verification is performed at 3.3 kW, achieving 93.76% efficiency at perfect alignment and 92.54% efficiency at 20 cm misalignment. The experimental verification is implemented at 3.3 kW with 200 mm ground clearance, realizing a 92.97% efficiency at perfect alignment and 90.57% efficiency at 20 cm misalignment.
- Published
- 2021
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7. Macro and microarchitectural features of sleep in Alzheimer’s dementia and mild cognitive impairment in a large clinical cohort
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Pathmanathan, Jay, primary, Zheng, Kevin, additional, Little, David, additional, Laberinto, Kim, additional, Sadeghi, Kolia, additional, Tjipterto, Dhany, additional, Arslan, Alexander, additional, Patino, Angelica, additional, Kleinschmidt, David, additional, Alday, Phillip, additional, Puryear, Corey, additional, Westover, M Brandon, additional, and Donoghue, Jacob, additional
- Published
- 2023
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8. Bilateral Leydig Cell Hyperplasia: A Rare Cause of Postmenopausal Hirsutism
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S. Pathmanathan, S. D. N. De Silva, M. Sumanatilleke, D. Lokuhetty, and U. V. V. Ranathunga
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background. Postmenopausal hirsutism could be due to a myriad of causes, including ovarian and adrenal tumours, ovarian hyperthecosis, exogenous androgens, and Cushing’s syndrome. We report a patient who was found to have a rare cause of postmenopausal hirsutism. Case Presentation. A 64-year-old postmenopausal woman with a history of hypertension, thyrotoxicosis, and poorly controlled diabetes on multiple oral hypoglycaemic agents presented with gradual onset progressive excessive hair growth without any virilizing features. On examination, she did not have Cushingnoid features or clitoromegaly. Her hirsutism was quantified with Ferriman–Gallwey score which was 9. Her biochemical evaluation showed elevated testosterone levels with normal DHEAS, ODST, 17-OHP, and prolactin. Low-dose dexamethasone suppression test did not suppress testosterone more than 40%. Contrast-enhanced CT of the adrenal and pelvis did not show any adrenal or ovarian mass lesions. Transvaginal ultrasound scan showed bilateral prominent ovaries only. Combined adrenal and ovarian venous sampling was carried out to localize the source of excess androgen, but only the left adrenal vein was successfully cannulated which showed suppressed testosterone level compared to periphery. The patient underwent total abdominal hysterectomy and bilateral salphingo oophorectomy, and her testosterone level normalized postoperatively. Her glycaemic control improved. Histology showed evidence of bilateral diffuse ovarian Leydig cell hyperplasia. Conclusion. Evaluation of postmenopausal hirsutism needs careful history and examination followed by biochemical evaluation and imaging. While adrenal and ovarian venous sampling can help to arrive at a diagnosis, it is a technically demanding procedure with low success rates even at centers of excellence. Therefore, in such situations, bilateral oophorectomy may be the best course of action which will give the histological confirmation of the diagnosis. Successful treatment of hyperandrogenism can result in improvement of glycaemic control. Bilateral diffuse Leydig cell hyperplasia is a rare but important cause of postmenopausal hirsutism.
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- 2022
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9. A Case Report of Leptomeningeal Myelomatosis and Rapid Improvement with Regimen Consisting of Daratumumab, Pomalidomide, Vincristine, Procarbazine, and Dexamethasone
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Jew Win Kuan, Sing Ling Chai, Pathmanathan Rajadurai, Lee Gong Lau, Joseph Uchang, and Sharifah Noor Akmal Syed Husain
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Central nervous system (CNS) involvement in multiple myeloma (MM) (MM-CNS) in the form of leptomeningeal myelomatosis or brain parenchyma plasmacytoma is rare, causing challenges in clinical diagnosis and treatment. We would like to report a case of leptomeningeal myelomatosis and illustrated the challeges. A 61-year-old man was diagnosed with MM with left paravertebral plasmacytoma, R-ISS II with high suspicion of double-hit MM, either biallelic aberrancy of TP53 or del(17p) and IGH aberrancy depending on the definition chosen, treated with lenalidomide-bortezomib-dexamethasone and local radiotherapy, later developed systemic relapse and progression to MM-CNS in the form of leptomeningeal myelomatosis. A modified CNS-based treatment not reported before, consisting of daratumumab, pomalidomide, vincristine, procarbazine, and dexamethasone, brought a rapid clinical improvement and warrants a further study. Incorporation of intrathecal thiotepa into the regimen would likely increase the efficacy.
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- 2022
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10. A Case of Successful Treatment with Unilateral Oophorectomy in a Patient with Resistant Polycystic Ovary Syndrome
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S. Pathmanathan, I. Ranathunga, and N. P. Somasundaram
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background. Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogeneous etiology. Typical features consist of oligo/anovulation, polycystic ovaries, and features of hyperandrogenism. Pathogenesis is multifactorial, and positive family history may have a predisposition for disease development. The syndrome is associated with multiple metabolic and nonmetabolic entities. As the disease is involved with multiple adverse outcomes, the successful treatment is pivotal. Among the more advanced options, the unilateral oophorectomy is considered as a last resort to alleviate the symptoms. Case Presentation. A 29-year-old female presented to us with oligomenorrhea, severe hirsutism, androgenic pattern hair loss, acne, increased skin pigmentation, and secondary subfertility. On examination, she was obese with a body mass index (BMI) of 29.6 kg/m2. She had evidence of acanthosis nigricans, androgenic pattern balding, acne, dorsal, supraclavicular fat deposition, and moderate-severe hirsutism. Investigations confirmed excess right ovarian testosterone secretion which led to the ultimate management with right oophorectomy with successful alleviation of clinical features. Conclusions. The multifaceted medical treatment comprises the first-line therapy in PCOS. Surgery is considered as a second-line option in resistant PCOS following failure of initial therapeutic options. We report a case of resistant polycystic ovary syndrome with secondary subfertility and moderate-to-severe hirsutism who was successfully treated with unilateral oophorectomy with favorable results.
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- 2020
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11. Machine learning for major food crops breeding: Applications, challenges, and ways forward
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N. Govaichelvan, Kumanan, primary, Pathmanathan, Dharini, additional, Zainal‐Abidin, Rabiatul‐Adawiah, additional, and Abu, Arpah, additional
- Published
- 2023
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12. Determinants of quality of life and hand function among people with hand osteoarthritis
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Cinthuja Pathmanathan, Leticia A. Deveza, Sarah R. Robbins, Vicky Duong, Venkatesha Venkatesha, and David J. Hunter
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Male ,Rheumatology ,Hand Joints ,Osteoarthritis ,Quality of Life ,Humans ,Pain ,Female ,Middle Aged ,Aged ,Pain Measurement - Abstract
The objectives of this study are to ascertain the determinants of quality of life (QoL) and hand function among persons with hand osteoarthritis (OA) and to assess the influence of hand function on QoL among persons with OA.Two hundred and four participants in a clinical trial completed the baseline assessment. Demographic, socioeconomic, QoL (AqoL-4D), hand function (Functional Index for Hand Osteoarthritis, FIHOA), pain assessment, radiographic and clinical characteristics of participants were measured using standard methods. Univariate and multivariate analyses were performed to evaluate potential associations.We studied 204 participants (76% female, age 65.63 ± 8.13 years, body mass index 28.7 ± 6.5 kg/mThe results indicate increasing impairment in hand function decreases the QoL of persons with hand OA. Some determinants were significantly associated with hand function and QoL. Determinants related to hand functions may be modifiable. In future, appropriate intervention strategies should be implemented, and further studies should be conducted to identify the effectiveness of those interventions.
- Published
- 2022
13. COVID‐19 death and kidney disease in a multiracial Asian country
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Bak Leong Goh, Malini Shanmuganathan, Kalaiarasu Peariasamy, Nor Arisah Misnan, Suresh Kumar Chidambaram, Eddie Fook Sem Wong, Mohan Dass Pathmanathan, Kim Liong Ang, Hin Seng Wong, and Lena Lay Ling Yeap
- Subjects
Adult ,Male ,kidney ,asian ,Racial Groups ,COVID-19 ,General Medicine ,Acute Kidney Injury ,Middle Aged ,malaysia ,Risk Factors ,Nephrology ,death ,Diabetes Mellitus ,Humans ,Female ,Hospital Mortality ,Prospective Studies ,Renal Insufficiency, Chronic ,Aged ,Retrospective Studies - Abstract
IntroductionCOVID-19 infection and kidney disease (KD) carry a considerable risk of mortality. Understanding predictors of death and KD may help improve management and patient outcome. MethodsThis is a prospective multi-centre observational study conducted in a multiracial Asian country to identify predictors of death and AKI in hospitalized COVID-19 patients from January to June 2020. ResultsA total of 6078 patients were included in this study. Mean age was 37.3(±16.8) years, 71% were male, 59.4% Malay, 6.7% Chinese, 2.3% Indian and 31.7% other ethnicities. Acute kidney injury (AKI) was seen in 3.5% of patients while 1.6% had pre-existing chronic kidney disease (CKD). Overall case fatality rate (CFR) was 1.3%. Patients with KD (AKI and CKD) had CFR of 20%. Many factors were associated with increased risk of death and AKI. However, significant predictors of death after adjustment for covariates were age (>70 years), Chinese ethnicity, diabetes mellitus (DM) and KD. Adjusted predictors of AKI were age (>51 years), DM and severity at presentation. Chinese were 2.58 times more likely to die (P=0.036) compared to Malay. Centre capacity to manage, ventilate and dialyze patients significantly influenced death. Among those with AKI, the most common symptoms were fever, cough, and dyspnea. They had lower absolute lymphocyte count, were more likely to be admitted to ICU, required more ventilation and longer hospitalization. ConclusionPatient and centre factors influence death and AKI among COVID-19 patients. This study also demonstrates death disparities across different racial groups and centre capacities in this multiracial Asian country.
- Published
- 2022
14. Artificial intelligence based digital scores of stromal tumour‐infiltrating lymphocytes and tumour‐associated stroma predict disease specific survival in triple‐negative breast cancer
- Author
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Albusayli, Rawan, primary, Graham, J. Dinny, additional, Pathmanathan, Nirmala, additional, Shaban, Muhammad, additional, Ahmed Raza, Shan E, additional, Minhas, Fayyaz, additional, Armes, Jane E., additional, and Rajpoot, Nasir, additional
- Published
- 2023
- Full Text
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15. Machine learning‐enabled epileptiform spike detection stratifies patient subpopulations with Alzheimer’s disease
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Pathmanathan, Jay, primary, Laberinto, Kim, additional, Robertson, Hannah, additional, Hanson, Eric, additional, and Donoghue, Jacob, additional
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- 2022
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16. Machine learning‐enabled epileptiform spike detection stratifies patient subpopulations with Alzheimer’s disease
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Jay Pathmanathan, Kim Laberinto, Hannah Robertson, Eric Hanson, and Jacob Donoghue
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
17. Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome
- Author
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Chandrika Jayakanthi Subasinghe, Noel Somasundaram, Pathmanathan Sivatharshya, Lalana Devi Ranasinghe, and Márta Korbonits
- Subjects
Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Multiple endocrine neoplasia (MEN) type 1 syndrome is an autosomal dominant disorder caused by germline mutations in MEN1 gene, characterized by tumours in endocrine and nonendocrine organs. Giant prolactinoma is defined as tumours larger than 40mm with very high prolactin secretion. We report two unrelated Sri Lankan patients (8-year-old boy and a 20-year-old female) who presented with giant prolactinomas with mass effects of the tumours. The female patient showed complete response to medical therapy, while the boy developed recurrent resistant prolactinoma needing surgery and radiotherapy. During follow-up, both developed pancreatic neuroendocrine tumours. Genetic analysis revealed that one was heterozygous for a nonsense mutation and other for missense mutation in MEN1 gene. Screening confirmed familial MEN-1 syndrome in their families. High clinical suspicion upon unusual clinical presentation prompted genetic evaluation in these patients and detection of MEN1 gene mutation. Pituitary adenomas in children with MEN-1 syndrome are larger tumours with higher rates of treatment resistance. This report emphasizes importance of screening young patients with giant prolactinoma for MEN-1 syndrome and arranging long-term follow-up for them expecting variable treatment outcomes. Sri Lanka requires further studies to describe the genotypic-phenotypic variability of MEN-1 syndrome in this population.
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- 2018
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18. Toxicity and response to ipilimumab and nivolumab in older patients with metastatic melanoma: A multicentre retrospective analysis
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Pathmanathan, Shivanshan, primary, Babu, Hari, additional, Dzienis, Marcin, additional, Azer, Mary, additional, and Eastgate, Melissa, additional
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- 2022
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19. Determinants of quality of life and hand function among people with hand osteoarthritis
- Author
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Pathmanathan, Cinthuja, primary, Deveza, Leticia A., additional, Robbins, Sarah R., additional, Duong, Vicky, additional, Venkatesha, Venkatesha, additional, and Hunter, David J., additional
- Published
- 2022
- Full Text
- View/download PDF
20. Open‐phase fault tolerant driving operation of dual‐inverter‐based traction drive
- Author
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Mehanathan Pathmanathan, Sepehr Semsar, Peter W. Lehn, and Caniggia Viana
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TK4001-4102 ,Computer science ,Control theory ,Traction drive ,Applications of electric power ,Phase (waves) ,Inverter ,Fault tolerance ,Electrical and Electronic Engineering ,Dual (category theory) - Abstract
A method for achieving open‐phase fault tolerant operation of a dual‐inverter‐based traction drive with charging capability is presented. This method utilises a contactor to connect the switching nodes of the two half bridges which are normally used for AC charging in this dual inverter configuration. These half bridges are then modulated to provide a path for zero‐sequence current and enhance the available voltage vector space of the drive by injecting a controllable common‐mode voltage between the two inverters. A control method and five‐level modulator based on zero‐sequence voltage control and phase shifted carriers are introduced to accommodate this novel remedial method. Using this approach, the open‐phase faulted dual inverter drive is able to operate with twice the speed range of the conventional open‐phase fault tolerant approach, which is to provide a path for zero‐sequence current by connecting the negative DC rails of the two inverters with a contactor. Simulation and experimental results with a prototype dual inverter drive are presented to validate the theory of the new control and modulation method. The experimental results showcase the proposed algorithms performance by dynamically responding to an open‐phase fault and starting from standstill, thereby proving its validity for an electric vehicle application.
- Published
- 2021
21. Author response for 'Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients'
- Author
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null Joaquin Baruch, null Amanda Rojek, null Christiana Kartsonaki, null Bharath K. T. Vijayaraghavan, null Bronner P. Gonçalves, null Mark G. Pritchard, null Laura Merson, null Jake Dunning, null Matthew Hall, null Louise Sigfrid, null Barbara W. Citarella, null Srinivas Murthy, null Trokon O. Yeabah, null Piero Olliaro, null Ali Abbas, null Sheryl Ann Abdukahil, null Nurul Najmee Abdulkadir, null Ryuzo Abe, null Laurent Abel, null Lara Absil, null Subhash Acharya, null Andrew Acker, null Elisabeth Adam, null Diana Adrião, null Saleh Al Ageel, null Shakeel Ahmed, null Kate Ainscough, null Eka Airlangga, null Tharwat Aisa, null Ali Ait Hssain, null Younes Ait Tamlihat, null Takako Akimoto, null Ernita Akmal, null Eman Al Qasim, null Razi Alalqam, null Angela Alberti, null Tala Al‐dabbous, null Senthilkumar Alegesan, null Cynthia Alegre, null Marta Alessi, null Beatrice Alex, null Kévin Alexandre, null Abdulrahman Al‐Fares, null Huda Alfoudri, null Imran Ali, null Adam Ali, null Naseem Ali Shah, null Kazali Enagnon Alidjnou, null Jeffrey Aliudin, null Qabas Alkhafajee, null Clotilde Allavena, null Nathalie Allou, null Aneela Altaf, null João Alves, null Rita Alves, null João Melo Alves, null Maria Amaral, null Nur Amira, null Phoebe Ampaw, null Roberto Andini, null Claire Andréjak, null Andrea Angheben, null François Angoulvant, null Séverine Ansart, null Sivanesen Anthonidass, null Massimo Antonelli, null Carlos Alexandre Antunes de Brito, null Ardiyan Apriyana, null Yaseen Arabi, null Irene Aragao, null Carolline Araujo, null Antonio Arcadipane, null Patrick Archambault, null Lukas Arenz, null Jean‐Benoît Arlet, null Lovkesh Arora, null Rakesh Arora, null Elise Artaud‐Macari, null Diptesh Aryal, null Angel Asensio, null Muhammad Ashraf, null Namra Asif, null Mohammad Asim, null Jean Baptiste Assie, null Amirul Asyraf, null Anika Atique, null A. M. Udara Lakshan Attanyake, null Johann Auchabie, null Hugues Aumaitre, null Adrien Auvet, null Eyvind W. Axelsen, null Laurène Azemar, null Cecile Azoulay, null Benjamin Bach, null Delphine Bachelet, null Claudine Badr, null Roar Bævre‐Jensen, null Nadia Baig, null J. Kenneth Baillie, null J. Kevin Baird, null Erica Bak, null Agamemnon Bakakos, null Nazreen Abu Bakar, null Andriy Bal, null Mohanaprasanth Balakrishnan, null Valeria Balan, null Firouzé Bani‐Sadr, null Renata Barbalho, null Nicholas Yuri Barbosa, null Wendy S. Barclay, null Saef Umar Barnett, null Michaela Barnikel, null Helena Barrasa, null Audrey Barrelet, null Cleide Barrigoto, null Marie Bartoli, null Joaquín Baruch, null Mustehan Bashir, null Romain Basmaci, null Muhammad Fadhli Hassin Basri, null Denise Battaglini, null Jules Bauer, null Diego Fernando Bautista Rincon, null Denisse Bazan Dow, null Abigail Beane, null Alexandra Bedossa, null Ker Hong Bee, null Husna Begum, null Sylvie Behilill, null Albertus Beishuizen, null Aleksandr Beljantsev, null David Bellemare, null Anna Beltrame, null Beatriz Amorim Beltrão, null Marine Beluze, null Nicolas Benech, null Lionel Eric Benjiman, null Dehbia Benkerrou, null Suzanne Bennett, null Luís Bento, null Jan‐Erik Berdal, null Delphine Bergeaud, null Hazel Bergin, null José Luis Bernal Sobrino, null Giulia Bertoli, null Lorenzo Bertolino, null Simon Bessis, null Sybille Bevilcaqua, null Karine Bezulier, null Amar Bhatt, null Krishna Bhavsar, null Claudia Bianco, null Farah Nadiah Bidin, null Moirangthem Bikram Singh, null Felwa Bin Humaid, null Mohd Nazlin Bin Kamarudin, null François Bissuel, null Laurent Bitker, null Jonathan Bitton, null Pablo Blanco‐Schweizer, null Catherine Blier, null Frank Bloos, null Mathieu Blot, null Filomena Boccia, null Laetitia Bodenes, null Alice Bogaarts, null Debby Bogaert, null Anne‐Hélène Boivin, null Pierre‐Adrien Bolze, null François Bompart, null Aurelius Bonfasius, null Diogo Borges, null Raphaël Borie, null Hans Martin Bosse, null Elisabeth Botelho‐Nevers, null Lila Bouadma, null Olivier Bouchaud, null Sabelline Bouchez, null Dounia Bouhmani, null Damien Bouhour, null Kévin Bouiller, null Laurence Bouillet, null Camile Bouisse, null Anne‐Sophie Boureau, null John Bourke, null Maude Bouscambert, null Aurore Bousquet, null Jason Bouziotis, null Bianca Boxma, null Marielle Boyer‐Besseyre, null Maria Boylan, null Fernando Augusto Bozza, null Axelle Braconnier, null Cynthia Braga, null Timo Brandenburger, null Filipa Brás Monteiro, null Luca Brazzi, null Patrick Breen, null Dorothy Breen, null Kathy Brickell, null Shaunagh Browne, null Alex Browne, null Nicolas Brozzi, null Sonja Hjellegjerde Brunvoll, null Marjolein Brusse‐Keizer, null Nina Buchtele, null Christian Buesaquillo, null Polina Bugaeva, null Marielle Buisson, null Danilo Buonsenso, null Erlina Burhan, null Aidan Burrell, null Ingrid G. Bustos, null Denis Butnaru, null André Cabie, null Susana Cabral, null Eder Caceres, null Cyril Cadoz, null Kate Calligy, null Jose Andres Calvache, null João Camões, null Valentine Campana, null Paul Campbell, null Josie Campisi, null Cecilia Canepa, null Mireia Cantero, null Pauline Caraux‐Paz, null Sheila Cárcel, null Chiara Simona Cardellino, null Sofia Cardoso, null Filipe Cardoso, null Filipa Cardoso, null Nelson Cardoso, null Simone Carelli, null Nicolas Carlier, null Thierry Carmoi, null Gayle Carney, null Inês Carqueja, null Marie‐Christine Carret, null François Martin Carrier, null Ida Carroll, null Gail Carson, null Maire‐Laure Casanova, null Mariana Cascão, null Siobhan Casey, null José Casimiro, null Bailey Cassandra, null Silvia Castañeda, null Nidyanara Castanheira, null Guylaine Castor‐Alexandre, null Henry Castrillón, null Ivo Castro, null Ana Catarino, null François‐Xavier Catherine, null Paolo Cattaneo, null Roberta Cavalin, null Giulio Giovanni Cavalli, null Alexandros Cavayas, null Adrian Ceccato, null Minerva Cervantes‐Gonzalez, null Anissa Chair, null Catherine Chakveatze, null Adrienne Chan, null Meera Chand, null Christelle Chantalat Auger, null Jean‐Marc Chapplain, null Julie Chas, null Allegra Chatterjee, null Mobin Chaudry, null Jonathan Samuel Chávez Iñiguez, null Anjellica Chen, null Yih‐Sharng Chen, null Matthew Pellan Cheng, null Antoine Cheret, null Thibault Chiarabini, null Julian Chica, null Suresh Kumar Chidambaram, null Leong Chin Tho, null Catherine Chirouze, null Davide Chiumello, null Sung‐Min Cho, null Bernard Cholley, null Marie‐Charlotte Chopin, null Ting Soo Chow, null Yock Ping Chow, null Jonathan Chua, null Hiu Jian Chua, null Jose Pedro Cidade, null José Miguel Cisneros Herreros, null Barbara Wanjiru Citarella, null Anna Ciullo, null Jennifer Clarke, null Emma Clarke, null Rolando Claure‐Del Granado, null Sara Clohisey, null Perren J. Cobb, null Cassidy Codan, null Caitriona Cody, null Alexandra Coelho, null Megan Coles, null Gwenhaël Colin, null Michael Collins, null Sebastiano Maria Colombo, null Pamela Combs, null Marie Connor, null Anne Conrad, null Sofía Contreras, null Elaine Conway, null Graham S. Cooke, null Mary Copland, null Hugues Cordel, null Amanda Corley, null Sabine Cornelis, null Alexander Daniel Cornet, null Arianne Joy Corpuz, null Andrea Cortegiani, null Grégory Corvaisier, null Emma Costigan, null Camille Couffignal, null Sandrine Couffin‐Cadiergues, null Roxane Courtois, null Stéphanie Cousse, null Rachel Cregan, null Sabine Croonen, null Gloria Crowl, null Jonathan Crump, null Claudina Cruz, null Juan Luis Cruz Bermúdez, null Jaime Cruz Rojo, null Marc Csete, null Ailbhe Cullen, null Matthew Cummings, null Gerard Curley, null Elodie Curlier, null Colleen Curran, null Paula Custodio, null Ana da Silva Filipe, null Charlene Da Silveira, null Al‐Awwab Dabaliz, null Andrew Dagens, null John Arne Dahl, null Darren Dahly, null Heidi Dalton, null Jo Dalton, null Seamus Daly, null Nick Daneman, null Corinne Daniel, null Emmanuelle A. Dankwa, null Jorge Dantas, null Frédérick D'Aragon, null Gillian de Loughry, null Diego de Mendoza, null Etienne De Montmollin, null Rafael Freitas de Oliveira França, null Ana Isabel de Pinho Oliveira, null Rosanna De Rosa, null Cristina De Rose, null Thushan de Silva, null Peter de Vries, null Jillian Deacon, null David Dean, null Alexa Debard, null Marie‐Pierre Debray, null Nathalie DeCastro, null William Dechert, null Lauren Deconninck, null Romain Decours, null Eve Defous, null Isabelle Delacroix, null Eric Delaveuve, null Karen Delavigne, null Nathalie M. Delfos, null Ionna Deligiannis, null Andrea Dell'Amore, null Christelle Delmas, null Pierre Delobel, null Corine Delsing, null Elisa Demonchy, null Emmanuelle Denis, null Dominique Deplanque, null Pieter Depuydt, null Mehul Desai, null Diane Descamps, null Mathilde Desvallées, null Santi Dewayanti, null Pathik Dhanger, null Alpha Diallo, null Sylvain Diamantis, null André Dias, null Juan Jose Diaz, null Priscila Diaz, null Rodrigo Diaz, null Kévin Didier, null Jean‐Luc Diehl, null Wim Dieperink, null Jérôme Dimet, null Vincent Dinot, null Fara Diop, null Alphonsine Diouf, null Yael Dishon, null Félix Djossou, null Annemarie B. Docherty, null Helen Doherty, null Arjen M. Dondorp, null Maria Donnelly, null Christl A. Donnelly, null Sean Donohue, null Yoann Donohue, null Chloe Donohue, null Peter Doran, null Céline Dorival, null Eric D'Ortenzio, null James Joshua Douglas, null Renee Douma, null Nathalie Dournon, null Triona Downer, null Joanne Downey, null Mark Downing, null Tom Drake, null Aoife Driscoll, null Murray Dryden, null Claudio Duarte Fonseca, null Vincent Dubee, null François Dubos, null Alexandre Ducancelle, null Toni Duculan, null Susanne Dudman, null Abhijit Duggal, null Paul Dunand, null Mathilde Duplaix, null Emanuele Durante‐Mangoni, null Lucian Durham, null Bertrand Dussol, null Juliette Duthoit, null Xavier Duval, null Anne Margarita Dyrhol‐Riise, null Sim Choon Ean, null Marco Echeverria‐Villalobos, null Siobhan Egan, null Linn Margrete Eggesbø, null Carla Eira, null Mohammed El Sanharawi, null Subbarao Elapavaluru, null Brigitte Elharrar, null Jacobien Ellerbroek, null Merete Ellingjord‐Dale, null Philippine Eloy, null Tarek Elshazly, null Iqbal Elyazar, null Isabelle Enderle, null Tomoyuki Endo, null Chan Chee Eng, null Ilka Engelmann, null Vincent Enouf, null Olivier Epaulard, null Martina Escher, null Mariano Esperatti, null Hélène Esperou, null Marina Esposito‐Farese, null João Estevão, null Manuel Etienne, null Nadia Ettalhaoui, null Anna Greti Everding, null Mirjam Evers, null Marc Fabre, null Isabelle Fabre, null Amna Faheem, null Arabella Fahy, null Cameron J. Fairfield, null Zul Fakar, null Komal Fareed, null Pedro Faria, null Ahmed Farooq, null Hanan Fateena, null Arie Zainul Fatoni, null Karine Faure, null Raphaël Favory, null Mohamed Fayed, null Niamh Feely, null Laura Feeney, null Jorge Fernandes, null Marília Andreia Fernandes, null Susana Fernandes, null François‐Xavier Ferrand, null Eglantine Ferrand Devouge, null Joana Ferrão, null Mário Ferraz, null Sílvia Ferreira, null Isabel Ferreira, null Benigno Ferreira, null Ricard Ferrer‐Roca, null Nicolas Ferriere, null Céline Ficko, null Claudia Figueiredo‐Mello, null William Finlayson, null Juan Fiorda, null Thomas Flament, null Clara Flateau, null Tom Fletcher, null Letizia Lucia Florio, null Deirdre Flynn, null Claire Foley, null Jean Foley, null Victor Fomin, null Tatiana Fonseca, null Patricia Fontela, null Simon Forsyth, null Denise Foster, null Giuseppe Foti, null Erwan Fourn, null Robert A. Fowler, null Marianne Fraher, null Diego Franch‐Llasat, null John F. Fraser, null Christophe Fraser, null Marcela Vieira Freire, null Ana Freitas Ribeiro, null Caren Friedrich, null Stéphanie Fry, null Nora Fuentes, null Masahiro Fukuda, null G. Argin, null Valérie Gaborieau, null Rostane Gaci, null Massimo Gagliardi, null Jean‐Charles Gagnard, null Amandine Gagneux‐Brunon, null Sérgio Gaião, null Linda Gail Skeie, null Phil Gallagher, null Carrol Gamble, null Yasmin Gani, null Arthur Garan, null Rebekha Garcia, null Noelia García Barrio, null Julia Garcia‐Diaz, null Esteban Garcia‐Gallo, null Navya Garimella, null Denis Garot, null Valérie Garrait, null Basanta Gauli, null Nathalie Gault, null Aisling Gavin, null Anatoliy Gavrylov, null Alexandre Gaymard, null Johannes Gebauer, null Eva Geraud, null Louis Gerbaud Morlaes, null Nuno Germano, null Praveen Kumar Ghisulal, null Jade Ghosn, null Marco Giani, null Jess Gibson, null Tristan Gigante, null Morgane Gilg, null Elaine Gilroy, null Guillermo Giordano, null Michelle Girvan, null Valérie Gissot, null Daniel Glikman, null Petr Glybochko, null Eric Gnall, null Geraldine Goco, null François Goehringer, null Siri Goepel, null Jean‐Christophe Goffard, null Jin Yi Goh, null Jonathan Golob, null Kyle Gomez, null Joan Gómez‐Junyent, null Marie Gominet, null Alicia Gonzalez, null Patricia Gordon, null Isabelle Gorenne, null Laure Goubert, null Cécile Goujard, null Tiphaine Goulenok, null Margarite Grable, null Jeronimo Graf, null Edward Wilson Grandin, null Pascal Granier, null Giacomo Grasselli, null Christopher A. Green, null Courtney Greene, null William Greenhalf, null Segolène Greffe, null Domenico Luca Grieco, null Matthew Griffee, null Fiona Griffiths, null Ioana Grigoras, null Albert Groenendijk, null Anja Grosse Lordemann, null Heidi Gruner, null Yusing Gu, null Jérémie Guedj, null Martin Guego, null Dewi Guellec, null Anne‐Marie Guerguerian, null Daniela Guerreiro, null Romain Guery, null Anne Guillaumot, null Laurent Guilleminault, null Maisa Guimarães de Castro, null Thomas Guimard, null Marieke Haalboom, null Daniel Haber, null Hannah Habraken, null Ali Hachemi, null Amy Hackmann, null Nadir Hadri, null Fakhir Haidri, null Sheeba Hakak, null Adam Hall, null Sophie Halpin, null Jawad Hameed, null Ansley Hamer, null Raph L. Hamers, null Rebecca Hamidfar, null Bato Hammarström, null Terese Hammond, null Lim Yuen Han, null Rashan Haniffa, null Kok Wei Hao, null Hayley Hardwick, null Ewen M. Harrison, null Janet Harrison, null Samuel Bernard Ekow Harrison, null Alan Hartman, null Mohd Shahnaz Hasan, null Junaid Hashmi, null Muhammad Hayat, null Ailbhe Hayes, null Leanne Hays, null Jan Heerman, null Lars Heggelund, null Ross Hendry, null Martina Hennessy, null Aquiles Henriquez‐Trujillo, null Maxime Hentzien, null Jaime Hernandez‐Montfort, null Andrew Hershey, null Liv Hesstvedt, null Astarini Hidayah, null Eibhilin Higgins, null Dawn Higgins, null Rupert Higgins, null Rita Hinchion, null Samuel Hinton, null Hiroaki Hiraiwa, null Haider Hirkani, null Hikombo Hitoto, null Yi Bin Ho, null Antonia Ho, null Alexandre Hoctin, null Isabelle Hoffmann, null Wei Han Hoh, null Oscar Hoiting, null Rebecca Holt, null Jan Cato Holter, null Peter Horby, null Juan Pablo Horcajada, null Koji Hoshino, null Ikram Houas, null Catherine L. Hough, null Stuart Houltham, null Jimmy Ming‐Yang Hsu, null Jean‐Sébastien Hulot, null Stella Huo, null Abby Hurd, null Iqbal Hussain, null Samreen Ijaz, null Hajnal‐Gabriela Illes, null Patrick Imbert, null Mohammad Imran, null Rana Imran Sikander, null Aftab Imtiaz, null Hugo Inácio, null Carmen Infante Dominguez, null Yun Sii Ing, null Elias Iosifidis, null Mariachiara Ippolito, null Sarah Isgett, null Tiago Isidoro, null Nadiah Ismail, null Margaux Isnard, null Mette Stausland Istre, null Junji Itai, null Daniel Ivulich, null Danielle Jaafar, null Salma Jaafoura, null Julien Jabot, null Clare Jackson, null Nina Jamieson, null Pierre Jaquet, null Coline Jaud‐Fischer, null Stéphane Jaureguiberry, null Denise Jaworsky, null Florence Jego, null Anilawati Mat Jelani, null Synne Jenum, null Ruth Jimbo‐Sotomayor, null Ong Yiaw Joe, null Ruth N. Jorge García, null Silje Bakken Jørgensen, null Cédric Joseph, null Mark Joseph, null Swosti Joshi, null Mercé Jourdain, null Philippe Jouvet, null Hanna Jung, null Anna Jung, null Dafsah Juzar, null Ouifiya Kafif, null Florentia Kaguelidou, null Neerusha Kaisbain, null Thavamany Kaleesvran, null Sabina Kali, null Alina Kalicinska, null Karl Trygve Kalleberg, null Smaragdi Kalomoiri, null Muhammad Aisar Ayadi Kamaluddin, null Zul Amali Che Kamaruddin, null Nadiah Kamarudin, null Kavita Kamineni, null Darshana Hewa Kandamby, null Chris Kandel, null Kong Yeow Kang, null Darakhshan Kanwal, null Pratap Karpayah, null Daisuke Kasugai, null Anant Kataria, null Kevin Katz, null Aasmine Kaur, null Christy Kay, null Hannah Keane, null Seán Keating, null Pulak Kedia, null Claire Kelly, null Yvelynne Kelly, null Andrea Kelly, null Niamh Kelly, null Aoife Kelly, null Sadie Kelly, null Maeve Kelsey, null Ryan Kennedy, null Kalynn Kennon, null Maeve Kernan, null Younes Kerroumi, null Sharma Keshav, null Imrana Khalid, null Osama Khalid, null Antoine Khalil, null Coralie Khan, null Irfan Khan, null Quratul Ain Khan, null Sushil Khanal, null Abid Khatak, null Amin Khawaja, null Krish Kherajani, null Michelle E. Kho, null Ryan Khoo, null Denisa Khoo, null Saye Khoo, null Nasir Khoso, null Khor How Kiat, null Yuri Kida, null Peter Kiiza, null Beathe Kiland Granerud, null Anders Benjamin Kildal, null Jae Burm Kim, null Antoine Kimmoun, null Detlef Kindgen‐Milles, null Alexander King, null Nobuya Kitamura, null Eyrun Floerecke Kjetland Kjetland, null Paul Klenerman, null Rob Klont, null Gry Kloumann Bekken, null Stephen R. Knight, null Robin Kobbe, null Chamira Kodippily, null Malte Kohns Vasconcelos, null Sabin Koirala, null Mamoru Komatsu, null Caroline Kosgei, null Arsène Kpangon, null Karolina Krawczyk, null Vinothini Krishnan, null Sudhir Krishnan, null Oksana Kruglova, null Ganesh Kumar, null Deepali Kumar, null Mukesh Kumar, null Pavan Kumar Vecham, null Dinesh Kuriakose, null Ethan Kurtzman, null Demetrios Kutsogiannis, null Galyna Kutsyna, null Konstantinos Kyriakoulis, null Marie Lachatre, null Marie Lacoste, null John G. Laffey, null Marie Lagrange, null Fabrice Laine, null Olivier Lairez, null Sanjay Lakhey, null Antonio Lalueza, null Marc Lambert, null François Lamontagne, null Marie Langelot‐Richard, null Vincent Langlois, null Eka Yudha Lantang, null Marina Lanza, null Cédric Laouénan, null Samira Laribi, null Delphine Lariviere, null Stéphane Lasry, null Sakshi Lath, null Naveed Latif, null Odile Launay, null Didier Laureillard, null Yoan Lavie‐Badie, null Andy Law, null Teresa Lawrence, null Cassie Lawrence, null Minh Le, null Clément Le Bihan, null Cyril Le Bris, null Georges Le Falher, null Lucie Le Fevre, null Quentin Le Hingrat, null Marion Le Maréchal, null Soizic Le Mestre, null Gwenaël Le Moal, null Vincent Le Moing, null Hervé Le Nagard, null Paul Le Turnier, null Ema Leal, null Marta Leal Santos, null Heng Gee Lee, null Biing Horng Lee, null Yi Lin Lee, null Todd C. Lee, null James Lee, null Jennifer Lee, null Su Hwan Lee, null Gary Leeming, null Laurent Lefebvre, null Bénédicte Lefebvre, null Benjamin Lefèvre, null Sylvie LeGac, null Jean‐Daniel Lelievre, null François Lellouche, null Adrien Lemaignen, null Véronique Lemee, null Anthony Lemeur, null Gretchen Lemmink, null Ha Sha Lene, null Jenny Lennon, null Rafael León, null Marc Leone, null Michela Leone, null Quentin Lepiller, null François‐Xavier Lescure, null Olivier Lesens, null Mathieu Lesouhaitier, null Amy Lester‐Grant, null Yves Levy, null Bruno Levy, null Claire Levy‐Marchal, null Katarzyna Lewandowska, null Erwan L'Her, null Gianluigi Li Bassi, null Janet Liang, null Ali Liaquat, null Geoffrey Liegeon, null Kah Chuan Lim, null Wei Shen Lim, null Chantre Lima, null Lim Lina, null Bruno Lina, null Andreas Lind, null Maja Katherine Lingad, null Guillaume Lingas, null Sylvie Lion‐Daolio, null Samantha Lissauer, null Keibun Liu, null Marine Livrozet, null Patricia Lizotte, null Antonio Loforte, null Navy Lolong, null Leong Chee Loon, null Diogo Lopes, null Dalia Lopez‐Colon, null Jose W. Lopez‐Revilla, null Anthony L. Loschner, null Paul Loubet, null Bouchra Loufti, null Guillame Louis, null Silvia Lourenco, null Lara Lovelace‐Macon, null Lee Lee Low, null Marije Lowik, null Jia Shyi Loy, null Jean Christophe Lucet, null Carlos Lumbreras Bermejo, null Carlos M. Luna, null Olguta Lungu, null Liem Luong, null Nestor Luque, null Dominique Luton, null Nilar Lwin, null Ruth Lyons, null Olavi Maasikas, null Oryane Mabiala, null Moïse Machado, null Gabriel Macheda, null Hashmi Madiha, null Guillermo Maestro de la Calle, null Rafael Mahieu, null Sophie Mahy, null Ana Raquel Maia, null Lars S. Maier, null Mylène Maillet, null Thomas Maitre, null Maximilian Malfertheiner, null Nadia Malik, null Paddy Mallon, null Fernando Maltez, null Denis Malvy, null Victoria Manda, null Laurent Mandelbrot, null Frank Manetta, null Julie Mankikian, null Edmund Manning, null Aldric Manuel, null Ceila Maria Sant'Ana Malaque, null Flávio Marino, null Daniel Marino, null Samuel Markowicz, null Charbel Maroun Eid, null Ana Marques, null Catherine Marquis, null Brian Marsh, null Laura Marsh, null Megan Marshal, null John Marshall, null Celina Turchi Martelli, null Dori‐Ann Martin, null Emily Martin, null Guillaume Martin‐Blondel, null Ignacio Martin‐Loeches, null Martin Martinot, null Alejandro Martin‐Quiros, null João Martins, null Ana Martins, null Nuno Martins, null Caroline Martins Rego, null Gennaro Martucci, null Olga Martynenko, null Eva Miranda Marwali, null Marsilla Marzukie, null David Maslove, null Sabina Mason, null Sobia Masood, null Basri Mat Nor, null Moshe Matan, null Meghena Mathew, null Daniel Mathieu, null Mathieu Mattei, null Romans Matulevics, null Laurence Maulin, null Michael Maxwell, null Javier Maynar, null Thierry Mazzoni, null Natalie Mc Evoy, null Lisa Mc Sweeney, null Colin McArthur, null Anne McCarthy, null Aine McCarthy, null Colin McCloskey, null Rachael McConnochie, null Sherry McDermott, null Sarah E. McDonald, null Aine McElroy, null Samuel McElwee, null Victoria McEneany, null Allison McGeer, null Chris McKay, null Johnny McKeown, null Kenneth A. McLean, null Paul McNally, null Bairbre McNicholas, null Elaine McPartlan, null Edel Meaney, null Cécile Mear‐Passard, null Maggie Mechlin, null Maqsood Meher, null Omar Mehkri, null Ferruccio Mele, null Luis Melo, null Kashif Memon, null Joao Joao Mendes, null Ogechukwu Menkiti, null Kusum Menon, null France Mentré, null Alexander J. Mentzer, null Noémie Mercier, null Emmanuelle Mercier, null Antoine Merckx, null Mayka Mergeay‐Fabre, null Blake Mergler, null António Mesquita, null Roberta Meta, null Osama Metwally, null Agnès Meybeck, null Dan Meyer, null Alison M. Meynert, null Vanina Meysonnier, null Amina Meziane, null Mehdi Mezidi, null Céline Michelanglei, null Isabelle Michelet, null Efstathia Mihelis, null Vladislav Mihnovit, null Hugo Miranda‐Maldonado, null Nor Arisah Misnan, null Tahira Jamal Mohamed, null Nik Nur Eliza Mohamed, null Asma Moin, null David Molina, null Elena Molinos, null Brenda Molloy, null Mary Mone, null Agostinho Monteiro, null Claudia Montes, null Giorgia Montrucchio, null Shona C. Moore, null Sarah Moore, null Lina Morales Cely, null Lucia Moro, null Ben Morton, null Catherine Motherway, null Ana Motos, null Hugo Mouquet, null Clara Mouton Perrot, null Julien Moyet, null Caroline Mudara, null Aisha Kalsoom Mufti, null Ng Yong Muh, null Dzawani Muhamad, null Jimmy Mullaert, null Fredrik Müller, null Karl Erik Müller, null Daniel Munblit, null Syed Muneeb, null Nadeem Munir, null Laveena Munshi, null Aisling Murphy, null Lorna Murphy, null Marlène Murris, null Himed Musaab, null Himasha Muvindi, null Gugapriyaa Muyandy, null Dimitra Melia Myrodia, null Farah Nadia Mohd‐Hanafiah, null Dave Nagpal, null Alex Nagrebetsky, null Mangala Narasimhan, null Nageswaran Narayanan, null Rashid Nasim Khan, null Alasdair Nazerali‐Maitland, null Nadège Neant, null Holger Neb, null Nikita Nekliudov, null Erni Nelwan, null Raul Neto, null Emily Neumann, null Pauline Yeung Ng, null Wing Yiu Ng, null Anthony Nghi, null Duc Nguyen, null Orna Ni Choileain, null Niamh Ni Leathlobhair, null Alistair Nichol, null Prompak Nitayavardhana, null Stephanie Nonas, null Nurul Amani Mohd Noordin, null Marion Noret, null Nurul Faten Izzati Norharizam, null Lisa Norman, null Alessandra Notari, null Mahdad Noursadeghi, null Karolina Nowicka, null Adam Nowinski, null Saad Nseir, null Jose I. Nunez, null Nurnaningsih Nurnaningsih, null Dwi Utomo Nusantara, null Elsa Nyamankolly, null Anders Benteson Nygaard, null Fionnuala O. Brien, null Annmarie O. Callaghan, null Annmarie O'Callaghan, null Giovanna Occhipinti, null Derbrenn OConnor, null Max O'Donnell, null Tawnya Ogston, null Takayuki Ogura, null Tak‐Hyuk Oh, null Sophie O'Halloran, null Katie O'Hearn, null Shinichiro Ohshimo, null Agnieszka Oldakowska, null João Oliveira, null Larissa Oliveira, null Piero L. Olliaro, null Jee Yan Ong, null David S. Y. Ong, null Wilna Oosthuyzen, null Anne Opavsky, null Peter Openshaw, null Saijad Orakzai, null Claudia Milena Orozco‐Chamorro, null Jamel Ortoleva, null Javier Osatnik, null Linda O'Shea, null Miriam O'Sullivan, null Siti Zubaidah Othman, null Nadia Ouamara, null Rachida Ouissa, null Eric Oziol, null Maïder Pagadoy, null Justine Pages, null Mario Palacios, null Amanda Palacios, null Massimo Palmarini, null Giovanna Panarello, null Prasan Kumar Panda, null Hem Paneru, null Lai Hui Pang, null Mauro Panigada, null Nathalie Pansu, null Aurélie Papadopoulos, null Rachael Parke, null Melissa Parker, null Briseida Parra, null Taha Pasha, null Jérémie Pasquier, null Bruno Pastene, null Fabian Patauner, null Drashti Patel, null Mohan Dass Pathmanathan, null Luís Patrão, null Patricia Patricio, null Juliette Patrier, null Lisa Patterson, null Rajyabardhan Pattnaik, null Mical Paul, null Christelle Paul, null Jorge Paulos, null William A. Paxton, null Jean‐François Payen, null Kalaiarasu Peariasamy, null Miguel Pedrera Jiménez, null Giles J. Peek, null Florent Peelman, null Nathan Peiffer‐Smadja, null Vincent Peigne, null Mare Pejkovska, null Paolo Pelosi, null Ithan D. Peltan, null Rui Pereira, null Daniel Perez, null Luis Periel, null Thomas Perpoint, null Antonio Pesenti, null Vincent Pestre, null Lenka Petrou, null Michele Petrovic, null Ventzislava Petrov‐Sanchez, null Frank Olav Pettersen, null Gilles Peytavin, null Scott Pharand, null Walter Picard, null Olivier Picone, null Maria de Piero, null Carola Pierobon, null Djura Piersma, null Carlos Pimentel, null Raquel Pinto, null Catarina Pires, null Isabelle Pironneau, null Lionel Piroth, null Ayodhia Pitaloka, null Riinu Pius, null Laurent Plantier, null Hon Shen Png, null Julien Poissy, null Ryadh Pokeerbux, null Maria Pokorska‐Spiewak, null Sergio Poli, null Georgios Pollakis, null Diane Ponscarme, null Jolanta Popielska, null Diego Bastos Porto, null Andra‐Maris Post, null Douwe F. Postma, null Pedro Povoa, null Diana Póvoas, null Jeff Powis, null Sofia Prapa, null Sébastien Preau, null Christian Prebensen, null Jean‐Charles Preiser, null Anton Prinssen, null Gamage Dona Dilanthi Priyadarshani, null Lucia Proença, null Sravya Pudota, null Oriane Puéchal, null Bambang Pujo Semedi, null Mathew Pulicken, null Gregory Purcell, null Luisa Quesada, null Vilmaris Quinones‐Cardona, null Víctor Quirós González, null Else Quist‐Paulsen, null Mohammed Quraishi, null Maia Rabaa, null Christian Rabaud, null Ebenezer Rabindrarajan, null Aldo Rafael, null Marie Rafiq, null Mutia Rahardjani, null Rozanah Abd Rahman, null Ahmad Kashfi Haji Ab Rahman, null Arsalan Rahutullah, null Fernando Rainieri, null Giri Shan Rajahram, null Pratheema Ramachandran, null Nagarajan Ramakrishnan, null Ahmad Afiq Ramli, null Blandine Rammaert, null Grazielle Viana Ramos, null Asim Rana, null Rajavardhan Rangappa, null Ritika Ranjan, null Christophe Rapp, null Aasiyah Rashan, null Thalha Rashan, null Ghulam Rasheed, null Menaldi Rasmin, null Indrek Rätsep, null Cornelius Rau, null Tharmini Ravi, null Ali Raza, null Andre Real, null Stanislas Rebaudet, null Sarah Redl, null Brenda Reeve, null Attaur Rehman, null Liadain Reid, null Dag Henrik Reikvam, null Renato Reis, null Jordi Rello, null Jonathan Remppis, null Martine Remy, null Hongru Ren, null Hanna Renk, null Anne‐Sophie Resseguier, null Matthieu Revest, null Oleksa Rewa, null Luis Felipe Reyes, null Tiago Reyes, null Maria Ines Ribeiro, null Antonia Ricchiuto, null David Richardson, null Denise Richardson, null Laurent Richier, null Siti Nurul Atikah Ahmad Ridzuan, null Jordi Riera, null Ana L. Rios, null Asgar Rishu, null Patrick Rispal, null Karine Risso, null Maria Angelica Rivera Nuñez, null Nicholas Rizer, null Chiara Robba, null André Roberto, null Stephanie Roberts, null David L. Robertson, null Olivier Robineau, null Ferran Roche‐Campo, null Paola Rodari, null Simão Rodeia, null Julia Rodriguez Abreu, null Bernhard Roessler, null Pierre‐Marie Roger, null Claire Roger, null Emmanuel Roilides, null Juliette Romaru, null Roberto Roncon‐Albuquerque, null Mélanie Roriz, null Manuel Rosa‐Calatrava, null Michael Rose, null Dorothea Rosenberger, null Nurul Hidayah Mohammad Roslan, null Andrea Rossanese, null Matteo Rossetti, null Bénédicte Rossignol, null Patrick Rossignol, null Stella Rousset, null Carine Roy, null Benoît Roze, null Desy Rusmawatiningtyas, null Clark D. Russell, null Maria Ryan, null Maeve Ryan, null Steffi Ryckaert, null Aleksander Rygh Holten, null Isabela Saba, null Sairah Sadaf, null Musharaf Sadat, null Valla Sahraei, null Maximilien Saint‐Gilles, null Pranya Sakiyalak, null Nawal Salahuddin, null Leonardo Salazar, null Jodat Saleem, null Gabriele Sales, null Stéphane Sallaberry, null Charlotte Salmon Gandonniere, null Hélène Salvator, null Olivier Sanchez, null Angel Sanchez‐Miralles, null Vanessa Sancho‐Shimizu, null Gyan Sandhu, null Zulfiqar Sandhu, null Pierre‐François Sandrine, null Oana Sandulescu, null Marlene Santos, null Shirley Sarfo‐Mensah, null Bruno Sarmento Banheiro, null Iam Claire E. Sarmiento, null Benjamine Sarton, null Ankana Satya, null Sree Satyapriya, null Rumaisah Satyawati, null Egle Saviciute, null Parthena Savvidou, null Yen Tsen Saw, null Justin Schaffer, null Tjard Schermer, null Arnaud Scherpereel, null Marion Schneider, null Stephan Schroll, null Michael Schwameis, null Gary Schwartz, null Janet T. Scott, null James Scott‐Brown, null Nicholas Sedillot, null Tamara Seitz, null Jaganathan Selvanayagam, null Mageswari Selvarajoo, null Caroline Semaille, null Malcolm G. Semple, null Rasidah Bt Senian, null Eric Senneville, null Filipa Sequeira, null Tânia Sequeira, null Ary Serpa Neto, null Pablo Serrano Balazote, null Ellen Shadowitz, null Syamin Asyraf Shahidan, null Mohammad Shamsah, null Anuraj Shankar, null Shaikh Sharjeel, null Pratima Sharma, null Catherine A. Shaw, null Victoria Shaw, null Ashraf Sheharyar, null Rohan Shetty, null Rajesh Mohan Shetty, null Haixia Shi, null Mohiuddin Shiekh, null Nobuaki Shime, null Keiki Shimizu, null Sally Shrapnel, null Pramesh Sundar Shrestha, null Shubha Kalyan Shrestha, null Hoi Ping Shum, null Nassima Si Mohammed, null Ng Yong Siang, null Jeanne Sibiude, null Atif Siddiqui, null Piret Sillaots, null Catarina Silva, null Rogério Silva, null Maria Joao Silva, null Benedict Sim Lim Heng, null Wai Ching Sin, null Dario Sinatti, null Punam Singh, null Budha Charan Singh, null Pompini Agustina Sitompul, null Karisha Sivam, null Vegard Skogen, null Sue Smith, null Benjamin Smood, null Coilin Smyth, null Michelle Smyth, null Morgane Snacken, null Dominic So, null Tze Vee Soh, null Lene Bergendal Solberg, null Joshua Solomon, null Tom Solomon, null Emily Somers, null Agnès Sommet, null Rima Song, null Myung Jin Song, null Tae Song, null Jack Song Chia, null Michael Sonntagbauer, null Azlan Mat Soom, null Arne Søraas, null Camilla Lund Søraas, null Alberto Sotto, null Edouard Soum, null Marta Sousa, null Ana Chora Sousa, null Maria Sousa Uva, null Vicente Souza‐Dantas, null Alexandra Sperry, null Elisabetta Spinuzza, null B. P. Sanka Ruwan Sri Darshana, null Shiranee Sriskandan, null Sarah Stabler, null Thomas Staudinger, null Stephanie‐Susanne Stecher, null Trude Steinsvik, null Ymkje Stienstra, null Birgitte Stiksrud, null Eva Stolz, null Amy Stone, null Adrian Streinu‐Cercel, null Anca Streinu‐Cercel, null David Stuart, null Ami Stuart, null Decy Subekti, null Gabriel Suen, null Jacky Y. Suen, null Asfia Sultana, null Charlotte Summers, null Dubravka Supic, null Deepashankari Suppiah, null Magdalena Surovcová, null Suwarti Suwarti, null Andrey Svistunov, null Sarah Syahrin, null Konstantinos Syrigos, null Jaques Sztajnbok, null Konstanty Szuldrzynski, null Shirin Tabrizi, null Fabio S. Taccone, null Lysa Tagherset, null Shahdattul Mawarni Taib, null Ewa Talarek, null Sara Taleb, null Jelmer Talsma, null Renaud Tamisier, null Maria Lawrensia Tampubolon, null Kim Keat Tan, null Yan Chyi Tan, null Taku Tanaka, null Hiroyuki Tanaka, null Hayato Taniguchi, null Huda Taqdees, null Arshad Taqi, null Coralie Tardivon, null Pierre Tattevin, null M. Azhari Taufik, null Hassan Tawfik, null Richard S. Tedder, null Tze Yuan Tee, null João Teixeira, null Sofia Tejada, null Marie‐Capucine Tellier, null Sze Kye Teoh, null Vanessa Teotonio, null François Téoulé, null Pleun Terpstra, null Olivier Terrier, null Nicolas Terzi, null Hubert Tessier‐Grenier, null Adrian Tey, null Alif Adlan Mohd Thabit, null Anand Thakur, null Zhang Duan Tham, null Suvintheran Thangavelu, null Vincent Thibault, null Simon‐Djamel Thiberville, null Benoît Thill, null Jananee Thirumanickam, null Shaun Thompson, null Emma C. Thomson, null Surain Raaj Thanga Thurai, null Ryan S. Thwaites, null Paul Tierney, null Vadim Tieroshyn, null Peter S. Timashev, null Jean‐François Timsit, null Bharath Kumar Tirupakuzhi Vijayaraghavan, null Noémie Tissot, null Jordan Zhien Yang Toh, null Maria Toki, null Kristian Tonby, null Sia Loong Tonnii, null Margarida Torres, null Antoni Torres, null Rosario Maria Torres Santos‐Olmo, null Hernando Torres‐Zevallos, null Michael Towers, null Tony Trapani, null Théo Treoux, null Cécile Tromeur, null Ioannis Trontzas, null Tiffany Trouillon, null Jeanne Truong, null Christelle Tual, null Sarah Tubiana, null Helen Tuite, null Jean‐Marie Turmel, null Lance C. W. Turtle, null Anders Tveita, null Pawel Twardowski, null Makoto Uchiyama, null P. G. Ishara Udayanga, null Andrew Udy, null Roman Ullrich, null Alberto Uribe, null Asad Usman, null Timothy M. Uyeki, null Cristinava Vajdovics, null Piero Valentini, null Luís Val‐Flores, null Amélie Valran, null Stijn Van de Velde, null Marcel van den Berge, null Machteld Van der Feltz, null Job van der Palen, null Paul van der Valk, null Nicky Van Der Vekens, null Peter Van der Voort, null Sylvie Van Der Werf, null Laura van Gulik, null Jarne Van Hattem, null Carolien van Netten, null Ilonka van Veen, null Noémie Vanel, null Henk Vanoverschelde, null Pooja Varghese, null Michael Varrone, null Shoban Raj Vasudayan, null Charline Vauchy, null Shaminee Veeran, null Aurélie Veislinger, null Sebastian Vencken, null Sara Ventura, null Annelies Verbon, null James Vickers, null José Ernesto Vidal, null César Vieira, null Deepak Vijayan, null Joy Ann Villanueva, null Judit Villar, null Pierre‐Marc Villeneuve, null Andrea Villoldo, null Gayatri Vishwanathan, null Benoit Visseaux, null Hannah Visser, null Chiara Vitiello, null Harald Vonkeman, null Fanny Vuotto, null Noor Hidayu Wahab, null Suhaila Abdul Wahab, null Nadirah Abdul Wahid, null Marina Wainstein, null Wan Fadzlina Wan Muhd Shukeri, null Chih‐Hsien Wang, null Steve Webb, null Jia Wei, null Katharina Weil, null Tan Pei Wen, null Sanne Wesselius, null T. Eoin West, null Murray Wham, null Bryan Whelan, null Nicole White, null Paul Henri Wicky, null Aurélie Wiedemann, null Surya Otto Wijaya, null Keith Wille, null Suzette Willems, null Virginie Williams, null Evert‐Jan Wils, null Xin Ci Wong, null Calvin Wong, null Yew Sing Wong, null Teck Fung Wong, null Natalie Wright, null Gan Ee Xian, null Lim Saio Xian, null Kuan Pei Xuan, null Ioannis Xynogalas, null Siti Rohani Binti Mohd Yakop, null Masaki Yamazaki, null Yazdan Yazdanpanah, null Nicholas Yee Liang Hing, null Cécile Yelnik, null Chian Hui Yeoh, null Stephanie Yerkovich, null Toshiki Yokoyama, null Hodane Yonis, null Obada Yousif, null Saptadi Yuliarto, null Akram Zaaqoq, null Marion Zabbe, null Kai Zacharowski, null Masliza Zahid, null Maram Zahran, null Nor Zaila Binti Zaidan, null Maria Zambon, null Alberto Zanella, null Konrad Zawadka, null Nurul Zaynah, null Hiba Zayyad, null Alexander Zoufaly, null David Zucman, and null ISARIC Clinical Characterisation Group
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- 2022
22. COVID‐19 death and kidney disease in a multiracial Asian country
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Goh, Bak Leong, primary, Shanmuganathan, Malini, additional, Peariasamy, Kalaiarasu, additional, Misnan, Nor Arisah, additional, Chidambaram, Suresh Kumar, additional, Wong, Eddie Fook Sem, additional, Pathmanathan, Mohan Dass, additional, Ang, Kim Liong, additional, Wong, Hin Seng, additional, and Yeap, Lena Lay Ling, additional
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- 2022
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23. Germline <scp> APOBEC3B </scp> deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, <scp> PIK3CA </scp> mutations and immune activation
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Pei-Sze Ng, Cheng Har Yip, Boon-Keat Chong, Carlos Caldas, Saira Bahnu, Siti Norhidayu Hasan, Soo Hwang Teo, Bethan Sandey, Oscar M. Rueda, Muhammad A. Zabidi, Mei-Yee Meng, Pathmanathan Rajadurai, Suet-Feung Chin, and Jia-Wern Pan
- Subjects
APOBEC ,Cancer Research ,Tumour heterogeneity ,Somatic hypermutation ,Biology ,medicine.disease ,Germline ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Oncology ,Polymorphism (computer science) ,030220 oncology & carcinogenesis ,Cancer research ,medicine ,Coding region ,Exome - Abstract
A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explored the relationship between the A3B deletion polymorphism with tumour characteristics in Asian women. Using whole exome and whole transcriptome sequencing data of 527 breast tumours, we report that germline A3B deletion polymorphism leads to expression of the A3A-B hybrid isoform and increased APOBEC-associated somatic hypermutation. Hypermutated tumours, regardless of A3B germline status, were associated with the Her2 molecular subtype and PIK3CA mutations. Compared to non-hypermutated tumours, hypermutated tumours also had higher neoantigen burden, tumour heterogeneity and immune activation. Taken together, our results suggest that the germline A3B deletion polymorphism, via the A3A-B hybrid isoform, contributes to APOBEC-mutagenesis in a significant proportion of Asian breast cancers. In addition, APOBEC somatic hypermutation, regardless of A3B background, may be an important clinical biomarker for Asian breast cancers. This article is protected by copyright. All rights reserved.
- Published
- 2021
24. Evaluation framework for systems models
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Braakman, Sietse, primary, Pathmanathan, Pras, additional, and Moore, Helen, additional
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- 2022
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25. Tuberculosis treatment within differentiated service delivery models in global HIV/TB programming
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Cuc H. Tran, Anand Date, Teeb Al-Samarrai, N Sarita Shah, Ikwo Oboho, Brittany K. Moore, Ishani Pathmanathan, Andrew T Boyd, Patrick Lungu, and Susan A. Maloney
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Tuberculosis ,Service delivery framework ,Health Personnel ,Best practice ,Supplement: Commentary ,HIV Infections ,differentiated service delivery ,Patient satisfaction ,tuberculosis treatment ,Health care ,Pandemic ,medicine ,Humans ,HIV treatment ,patient‐centred care ,National TB and Leprosy Programme ,persons living with HIV ,SARS-CoV-2 ,business.industry ,Public Health, Environmental and Occupational Health ,COVID-19 ,Differentiated service ,medicine.disease ,Infectious Diseases ,tuberculosis ,Medical emergency ,business ,Patient education - Abstract
Introduction Providing more convenient and patient‐centred options for service delivery is a priority within global HIV programmes. These efforts improve patient satisfaction and retention and free up time for providers to focus on new HIV diagnoses or severe illness. Recently, the coronavirus disease 2019 (COVID‐19) pandemic precipitated expanded eligibility criteria for these differentiated service delivery (DSD) models to decongest clinics and protect patients and healthcare workers. This has resulted in dramatic scale‐up of DSD for antiretroviral therapy, cotrimoxazole and tuberculosis (TB) preventive treatment. While TB treatment among people living with HIV (PLHIV) has traditionally involved frequent, facility‐based management, TB treatment can also be adapted within DSD models. Such adaptations could include electronic tools to ensure appropriate clinical management, treatment support, adherence counselling and adverse event (AE) monitoring. In this commentary, we outline considerations for DSD of TB treatment among PLHIV, building on best practices from global DSD model implementation for HIV service delivery. Discussion In operationalizing TB treatment in DSD models, we consider the following: what activity is being done, when or how often it takes place, where it takes place, by whom and for whom. We discuss considerations for various programme elements including TB screening and diagnosis; medication dispensing; patient education, counselling and support; clinical management and monitoring; and reporting and recording. General approaches include multi‐month dispensing for TB medications during intensive and continuation phases of treatment and standardized virtual adherence and AE monitoring. Lastly, we provide operational examples of TB treatment delivery through DSD models, including a conceptual model and an early implementation experience from Zambia. Conclusions COVID‐19 has catalysed the rapid expansion of differentiated patient‐centred service delivery for PLHIV. Expanding DSD models to include TB treatment can capitalize on existing platforms, while providing high‐quality, routine treatment, follow‐up and patient education and empowerment.
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- 2021
26. Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications
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McCart Reed, AE, Kalaw, E, Nones, K, Bettington, M, Lim, M, Bennett, J, Johnstone, K, Kutasovic, JR, Saunus, JM, Kazakoff, S, Xu, Q, Wood, S, Holmes, O, Leonard, C, Reid, LE, Black, D, Niland, C, Ferguson, K, Gresshoff, I, Raghavendra, A, Harvey, K, Cooper, C, Liu, C, Kalinowski, L, Reid, AS, Davidson, M, Pearson, JV, Pathmanathan, N, Tse, G, Papadimos, D, Pathmanathan, R, Harris, G, Yamaguchi, R, Tan, PH, Fox, SB, O'Toole, SA, Simpson, PT, Waddell, N, Lakhani, SR, McCart Reed, AE, Kalaw, E, Nones, K, Bettington, M, Lim, M, Bennett, J, Johnstone, K, Kutasovic, JR, Saunus, JM, Kazakoff, S, Xu, Q, Wood, S, Holmes, O, Leonard, C, Reid, LE, Black, D, Niland, C, Ferguson, K, Gresshoff, I, Raghavendra, A, Harvey, K, Cooper, C, Liu, C, Kalinowski, L, Reid, AS, Davidson, M, Pearson, JV, Pathmanathan, N, Tse, G, Papadimos, D, Pathmanathan, R, Harris, G, Yamaguchi, R, Tan, PH, Fox, SB, O'Toole, SA, Simpson, PT, Waddell, N, and Lakhani, SR
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- 2019
27. Tuberculosis treatment within differentiated service delivery models in global HIV/TB programming
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Tran, Cuc H., primary, Moore, Brittany K., additional, Pathmanathan, Ishani, additional, Lungu, Patrick, additional, Shah, N. Sarita, additional, Oboho, Ikwo, additional, Al‐Samarrai, Teeb, additional, Maloney, Susan A., additional, Date, Anand, additional, and Boyd, Andrew T., additional
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- 2021
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- View/download PDF
28. Annual home‐based HIV testing in the Chókwè Health Demographic Surveillance System, Mozambique, 2014 to 2019: serial population‐based survey evaluation
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MacKellar, Duncan, primary, Thompson, Ricardo, additional, Nelson, Robert, additional, Casavant, Isabelle, additional, Pals, Sherri, additional, Bonzela, Juvencio, additional, Jaramillo, Alicia, additional, Cardoso, Judite, additional, Ujamaa, Dawud, additional, Tamele, Stelio, additional, Chivurre, Victor, additional, Malimane, Inacio, additional, Pathmanathan, Ishani, additional, Heitzinger, Kristen, additional, Wei, Stanley, additional, Couto, Aleny, additional, and Vergara, Alfredo, additional
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- 2021
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29. Electroencephalographic Abnormalities are Common in COVID‐19 and are Associated with Outcomes
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Lin, Lu, primary, Al‐Faraj, Abrar, additional, Ayub, Neishay, additional, Bravo, Pablo, additional, Das, Sudeshna, additional, Ferlini, Lorenzo, additional, Karakis, Ioannis, additional, Lee, Jong Woo, additional, Mukerji, Shibani S., additional, Newey, Christopher R., additional, Pathmanathan, Jay, additional, Abdennadher, Myriam, additional, Casassa, Charles, additional, Gaspard, Nicolas, additional, Goldenholz, Daniel M., additional, Gilmore, Emily J., additional, Jing, Jin, additional, Kim, Jennifer A., additional, Kimchi, Eyal Y., additional, Ladha, Harshad S., additional, Tobochnik, Steven, additional, Zafar, Sahar, additional, Hirsch, Lawrence J., additional, Westover, M. Brandon, additional, and Shafi, Mouhsin M., additional
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- 2021
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30. Delays in lung cancer management pathways between rural and urban patients in North Queensland: a mixed methods study
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Petra Buttner, Shivanshan Pathmanathan, Rishabh Verma, Venkat N. Vangaveti, Sabe Sabesan, John Binder, and Zulfiquer Otty
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Time delays ,medicine.medical_specialty ,Referral ,business.industry ,Cancer ,Disease ,Stage ii ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Emergency medicine ,Internal Medicine ,medicine ,030212 general & internal medicine ,Prospective cohort study ,Stage iv ,business ,Lung cancer - Abstract
INTRODUCTION: Aims of this study were to examine time delays in lung cancer referral pathways in North Queensland (NQ), Australia, and explore patients' perspective of factors causing these delays. METHODS: Prospective study of patients attending three cancer centres in Townsville, Cairns and Mackay in NQ from 2009 to 2012. Times along referral pathway were divided as follows: Onset of symptoms to treatment (T1), symptoms to general practitioner(GP) (T2), GP to specialist (T3), and Specialist to treatment (T4). Quantitative and qualitative methods were used for analysis. RESULTS: 252 patients participated. T1 was influenced by remoteness (125 days in Townsville vs. 170 days for Remote, p=0.01), T2 by level of education (91 days for Primary education vs. 61 days for Secondary vs. 23 days for Tertiary/TAFE, p=0.006), and age group (14 days for 31-50 years, 61 days for 51-70 years, 45 days for >71 years, p=0.026), T3 by remoteness (15 days for Townville and 29.5 days for remote, p=0.02) and T4 by stage of disease (21 days for stage I, 11 days for Stage II, 34 days for Stage III 18 days for Stage IV, p=0.041). Competing priorities of family and work and cost & inconvenience of travel were perceived as rural barriers. CONCLUSION: Remoteness, age and level of education were related to delays in various time lines in lung cancer referral pathways in NQ. Provision of specialist services closer to home may decrease delays by alleviating burden of cost and inconvenience of travel.
- Published
- 2018
31. Cytotoxic, Antiproliferative and Apoptosis-inducing Activity of L-Amino Acid Oxidase from MalaysianCalloselasma rhodostomaon Human Colon Cancer Cells
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Iekhsan Othman, Muhammad Rusdi Ahmad Rusmili, Rakesh Naidu, Md. Ezharul Hoque Chowdhury, Pathmanathan Rajadurai, and Syafiq Asnawi Zainal Abidin
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0301 basic medicine ,Population ,Antineoplastic Agents ,Apoptosis ,L-Amino Acid Oxidase ,Toxicology ,L-amino-acid oxidase ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,Crotalid Venoms ,Humans ,Cytotoxic T cell ,Cytotoxicity ,education ,Cell Proliferation ,Pharmacology ,education.field_of_study ,Dose-Response Relationship, Drug ,biology ,Caspase 3 ,Cytotoxins ,Chemistry ,Calloselasma rhodostoma ,Cell growth ,Malaysia ,General Medicine ,biology.organism_classification ,Molecular biology ,030104 developmental biology ,Cell culture ,030220 oncology & carcinogenesis ,Colonic Neoplasms - Abstract
The aim of this study was to investigate the cytotoxic, antiproliferative activity and the induction of apoptosis by L-amino acid oxidase isolated from Calloselasma rhodostoma crude venom (CR-LAAO) on human colon cancer cells. CR-LAAO was purified using three chromatographic steps: molecular exclusion using G-50 gel filtration resin, ion-exchange by MonoQ column and desalted on a G25 column. The purity and identity of the isolated CR-LAAO was confirmed by SDS-PAGE and LC-MS/MS. CR-LAAO demonstrated time- and dose-dependent cytotoxic activity on SW480 (primary human colon cancer cells) and SW620 (metastatic human colon cancer cells) with an EC50 values of 6 μg/ml and 7 μg/ml at 48 hr, respectively. Quantification of apoptotic cells based on morphological features demonstrated significant increase in apoptotic cell population in both SW480 and SW620 cells which peaked at 48 hr. Significant increase in caspase-3 activity and reduction in Bcl-2 levels were demonstrated following CR-LAAO treatment. These data provide evidence on the potential anticancer activity of CR-LAAO from the venom of C. rhodostoma for therapeutic intervention of human colon cancer.
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- 2018
32. GermlineAPOBEC3Bdeletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype,PIK3CAmutations and immune activation
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Pan, Jia‐Wern, primary, Zabidi, Muhammad Mamduh Ahmad, additional, Chong, Boon‐Keat, additional, Meng, Mei‐Yee, additional, Ng, Pei‐Sze, additional, Hasan, Siti Norhidayu, additional, Sandey, Bethan, additional, Bahnu, Saira, additional, Rajadurai, Pathmanathan, additional, Yip, Cheng‐Har, additional, Rueda, Oscar M., additional, Caldas, Carlos, additional, Chin, Suet‐Feung, additional, and Teo, Soo‐Hwang, additional
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- 2021
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33. Mapping the MET Receptor Tyrosine Kinase Interactome using Mammalian Membrane Two Hybrid (MaMTH) system
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Pathmanathan, Shivanthy, primary, Yao, Zhong, additional, Snider, Jamie, additional, Drecun, Luka, additional, Benz, Caroline, additional, Stern, Yaakov, additional, Park, Morag, additional, and Stagljar, Igor, additional
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- 2020
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34. Process measure aimed at reducing time to haemorrhage control: outcomes associated with Code Crimson activation in exsanguinating truncal trauma
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Tovmassian, David, primary, Hameed, Ahmer M., additional, Ly, Jessie, additional, Pathmanathan, Nimalan, additional, Devadas, Michael, additional, Gomez, David, additional, and Hsu, Jeremy M., additional
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- 2020
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- View/download PDF
35. Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications
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McCart Reed, Amy Ellen, primary, Kalaw, Emarene, additional, Nones, Katia, additional, Bettington, Mark, additional, Lim, Malcolm, additional, Bennett, James, additional, Johnstone, Kate, additional, Kutasovic, Jamie Rose, additional, Saunus, Jodi Marie, additional, Kazakoff, Stephen, additional, Xu, Qinying, additional, Wood, Scott, additional, Holmes, Oliver, additional, Leonard, Conrad, additional, Reid, Lynne Estelle, additional, Black, Debra, additional, Niland, Colleen, additional, Ferguson, Kaltin, additional, Gresshoff, Irma, additional, Raghavendra, Ashwini, additional, Harvey, Kate, additional, Cooper, Caroline, additional, Liu, Cheng, additional, Kalinowski, Lauren, additional, Reid, Andrew Scott, additional, Davidson, Morgan, additional, Pearson, John V, additional, Pathmanathan, Nirmala, additional, Tse, Gary, additional, Papadimos, David, additional, Pathmanathan, Rajadurai, additional, Harris, Gavin, additional, Yamaguchi, Rin, additional, Tan, Puay Hoon, additional, Fox, Stephen B, additional, O'Toole, Sandra A, additional, Simpson, Peter Thomas, additional, Waddell, Nicola, additional, and Lakhani, Sunil R, additional
- Published
- 2018
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36. Relationship between acne vulgaris and cosmetic usage in Sri Lankan urban adolescent females
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Sudaraka Mallawaarachchi, Indika Karunathilake, Wadu Mesthrige Dilhani Mihiri Peiris, Magelage Prabhavi Nilupulee Perera, and Diranjala Pathmanathan
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0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Urban Population ,Population ,Cosmetics ,Dermatology ,Severity of Illness Index ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Acne Vulgaris ,Prevalence ,medicine ,Humans ,Risk factor ,Grading (education) ,education ,Depression (differential diagnoses) ,Acne ,Sri Lanka ,education.field_of_study ,business.industry ,medicine.disease ,Cross-Sectional Studies ,030104 developmental biology ,Population study ,Female ,Sri lanka ,business ,Psychosocial - Abstract
SummaryBackground Acne vulgaris is one of the commonest skin disorders affecting up to 80% of the world population at least during adolescence. Significant psychosocial effects such as depression and poor personality development have been linked with acne, especially in female adolescents. Various causative factors, including cosmetic exposure, have been attributed toward acne. Objective To analyze the association between frequent exposure to cosmetics and severity of acne in adolescent females. Method A cross-sectional analytical study was performed on 140 girls from three schools in Colombo, Sri Lanka. A self-administered questionnaire was utilized to assess the patterns of cosmetic usage. Grading acne of the participants was performed by the researchers utilizing a standard acne grading scale. Results The overall prevalence of acne in our study population was 91.4% with a mean acne grade of 3.09. At least one cosmetic type was used by 126 (90%) of the population. A Pearson correlation coefficient (r) value of .452 (P
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- 2017
37. Human epidermal growth factor receptor 2 status of gastric cancer patients in Asia: results from a large, multicountry study
- Author
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John Wang, Xiu Nie, Jing-shu Geng, Michael Bilous, Wencai Li, Nirmala Pathmanathan, Julie Hill, Januario Veloso, and Philip McCloud
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0301 basic medicine ,business.industry ,Cancer ,General Medicine ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Medicine ,business ,Human Epidermal Growth Factor Receptor 2 - Published
- 2016
38. Sensing fermentation degree of cocoa (Theobroma cacao L.) beans by machine learning classification models based electronic nose system
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Saila Ramkissoon, Pathmanathan Umaharan, Darin A. Sukha, Balu M. Balasubramanian, and Juzhong Tan
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0106 biological sciences ,Electronic nose ,biology ,business.industry ,Theobroma ,General Chemical Engineering ,Decision tree ,04 agricultural and veterinary sciences ,Agricultural engineering ,COCOA BEAN ,biology.organism_classification ,040401 food science ,01 natural sciences ,food.food ,Degree (temperature) ,Statistical classification ,0404 agricultural biotechnology ,food ,010608 biotechnology ,Food processing ,Fermentation ,business ,Food Science ,Mathematics - Abstract
Cocoa bean fermentation is an important postharvest process that develops aroma and processing properties. Although the cocoa fermentation is of high complexly, farmers are employing empirical methods to determine the fermentation degree of cocoa. Researchers, on the other hand, are using expensive equipment such as high‐performance liquid chromatography and gas chromatography‐mass spectrometry to study cocoa fermentation. In this study, machine learning based electronic nose system, a fast measuring and affordable method, was developed to determine the fermentation degree of cocoa beans. Six machine‐learning methods (bootstrap forest, boosted tree, decision tree, artificial neural network (ANN), naive Bayes, and k‐nearest neighbors) were conducted to classify the fermentation time of cocoa beans. Bootstrap forest algorithm achieved a misclassification rate as low as 9.4%. ANN and boosted tree achieved 12.8 and 13.6% misclassification rate respectively. However, other methods failed to do classification for cocoa beans. PRACTICAL APPLICATIONS: The electronic nose system can be used by cocoa farmers to monitor cocoa fermentation and ensure the quality of cocoa beans. The method is relatively inexpensive and easy to operate.
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- 2019
39. Bipartite graph analyses reveal interdomain LGT involving ultrasmall prokaryotes and their divergent, membrane-related proteins
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Eric Bapteste, Jananan S. Pathmanathan, Alexander L. Jaffe, Eduardo Corel, and Philippe Lopez
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0301 basic medicine ,Phylum ,Intracellular parasite ,Computational biology ,Biology ,biology.organism_classification ,Bioinformatics ,Microbiology ,Genome ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Membrane protein ,Phylogenetics ,Gene ,030217 neurology & neurosurgery ,Ecology, Evolution, Behavior and Systematics ,Bacteria ,Archaea - Abstract
Based on their small size and genomic properties, ultrasmall prokaryotic groups like the Candidate Phyla Radiation have been proposed as possible symbionts dependent on other bacteria or archaea. In this study, we use a bipartite graph analysis to examine patterns of sequence similarity between draft and complete genomes from ultrasmall bacteria and other complete prokaryotic genomes, assessing whether the former group might engage in significant gene transfer (or even endosymbioses) with other community members. Our results provide preliminary evidence for many lateral gene transfers with other prokaryotes, including members of the archaea, and report the presence of divergent, membrane-associated proteins among these ultrasmall taxa. In particular, these divergent genes were found in TM6 relatives of the intracellular parasite Babela massiliensis.
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- 2016
40. Axillary reverse mapping in patients with breast cancer: Is it oncologically safe?
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Elisabeth Elder, James French, Nicholas K. Ngui, Christopher J. Kilby, and Nirmala Pathmanathan
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Sentinel lymph node ,Axillary Lymph Node Dissection ,General Medicine ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Lymphatic system ,Breast cancer ,medicine.anatomical_structure ,Lymphedema ,Oncology ,030220 oncology & carcinogenesis ,Biopsy ,medicine ,030211 gastroenterology & hepatology ,Histopathology ,business ,Lymph node - Abstract
Background Axillary reverse mapping (ARM) is a technique used to identify the lymphatics draining the arm. The aim of this study was to examine the prevalence and predictors of ARM node metastases in breast cancer patients undergoing an axillary lymph node dissection (ALND). Methods A total of 87 patients were enrolled in this study. Patent V Blue dye was injected in the upper arm for ARM node localization. All patients had an ALND with the identified ARM node removed and sent separately for histologic analysis. Results Of 67 (77%) patients in whom an ARM node was identified, 49 (73%) were negative and 18 (27%) were positive for metastases on final histopathology. Positive ARM node status was significantly associated with advanced axillary disease, and larger primary cancers. Patients requiring a completion ALND due to a positive sentinel lymph node biopsy (SLNB) with non-suspicious ARM nodes during surgery did not have ARM node metastases. Conclusions There is a high risk of ARM node involvement, approximately a quarter, in patients with preoperatively known lymph node metastases from breast cancer. However, it may be safe to preserve a clinically non-suspicious ARM node in patients with a positive SLNB who require a completion ALND. J. Surg. Oncol. 2016;113:726–731. © 2016 Wiley Periodicals, Inc.
- Published
- 2016
41. Mapping the MET Receptor Tyrosine Kinase Interactome using Mammalian Membrane Two Hybrid (MaMTH) system
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Luka Drecun, Shivanthy Pathmanathan, Caroline Benz, Zhong Yao, Yaakov E. Stern, Jamie Snider, Igor Stagljar, and Morag Park
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MET Receptor Tyrosine Kinase ,Membrane ,Chemistry ,Genetics ,Molecular Biology ,Biochemistry ,Interactome ,Biotechnology ,Cell biology - Published
- 2020
42. Sensing fermentation degree of cocoa (Theobroma cacao L.) beans by machine learning classification models based electronic nose system
- Author
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Tan, Juzhong, primary, Balasubramanian, Balu, additional, Sukha, Darin, additional, Ramkissoon, Saila, additional, and Umaharan, Pathmanathan, additional
- Published
- 2019
- Full Text
- View/download PDF
43. Improving fiducial and prostate capsule visualization for radiotherapy planning usingMRI
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Pathmanathan, Angela U., primary, Schmidt, Maria A., additional, Brand, Douglas H., additional, Kousi, Evanthia, additional, As, Nicholas J., additional, and Tree, Alison C., additional
- Published
- 2019
- Full Text
- View/download PDF
44. Implementation of Child Rights in the Children's Homes in Malaysia
- Author
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M. Rezaul Islam, Noralina Omar, Haris Abd Wahab, Jal Zabdi Mohd Yusoff, Pathmanathan R. Nalasami, and Siti Hajar Abu Bakar
- Subjects
Government ,Sociology and Political Science ,media_common.quotation_subject ,Child rights ,Social Welfare ,Multiple data ,Documentation ,Nursing ,Political science ,Structured interview ,Welfare ,Social Sciences (miscellaneous) ,Convention on the Rights of the Child ,media_common - Abstract
The objective of this study was to examine the implementation of the Convention on the Rights of the Child (CRC) in the Children Homes under the Social Welfare Department (SWD) in Malaysia. Data was collected from 402 registered children who were staying in six Children Homes across the country. This study employed self-report surveys where multiple data collection methods, such as face-to-face structured interviews, key informant interviews (KIIs), and documentation survey, were used. The study found that the SWD failed to comply with most of the commitments of CRC in Children Homes at its implementation level, and it is still needs based. The findings of this study present important guidelines for government and policy makers in improving child welfare services in the Children Homes in Malaysia.
- Published
- 2015
45. Relationship between acne vulgaris and cosmetic usage in Sri Lankan urban adolescent females
- Author
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Perera, MPN, Peiris, WMDM, Pathmanathan, D, Mallawaarachchi, S, Karunathilake, IM, Perera, MPN, Peiris, WMDM, Pathmanathan, D, Mallawaarachchi, S, and Karunathilake, IM
- Abstract
Background Acne vulgaris is one of the commonest skin disorders affecting up to 80% of the world population at least during adolescence. Significant psychosocial effects such as depression and poor personality development have been linked with acne, especially in female adolescents. Various causative factors, including cosmetic exposure, have been attributed toward acne. Objective To analyze the association between frequent exposure to cosmetics and severity of acne in adolescent females. Method A cross-sectional analytical study was performed on 140 girls from three schools in Colombo, Sri Lanka. A self-administered questionnaire was utilized to assess the patterns of cosmetic usage. Grading acne of the participants was performed by the researchers utilizing a standard acne grading scale. Results The overall prevalence of acne in our study population was 91.4% with a mean acne grade of 3.09. At least one cosmetic type was used by 126 (90%) of the population. A Pearson correlation coefficient (r) value of .452 (P < .001) was obtained between cosmetic exposure and acne grade, which indicates a statistically significant correlation. A chi-square value of 22.875 was obtained at a degree of freedom of 2 (P < .001), enabling us to reject the null hypothesis that there is no significant association between cosmetic usage and acne severity. Conclusion Our results convey a significant positive association between frequent exposure to cosmetics and severity of acne in adolescent females. Girls of this age group must be made aware that cosmetic usage may be a potential aggravating factor for their facial acne.
- Published
- 2018
46. Intraoperative sentinel lymph node assessment in breast cancer: a comparison of rapid diagnostic method based on CK19 mRNA expression and imprint cytology
- Author
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James French, Christina Hui‐Leng Teh, Michael Bilous, Jasveen Renthawa, Nirmala Pathmanathan, Hema Mahajan, Elizabeth Edstrom-Elder, and Geoffrey Hall
- Subjects
medicine.medical_specialty ,Pathology ,business.industry ,Sentinel lymph node ,H&E stain ,General Medicine ,Nucleic acid amplification technique ,Sentinel node ,medicine.disease ,Axilla ,Breast cancer ,medicine.anatomical_structure ,Cytology ,medicine ,Surgery ,Radiology ,business ,Cancer staging - Abstract
Background Sentinel lymph node biopsy in breast cancer is a routine technique for staging the axilla. The two most common methods of intraoperative histopathological assessment, imprint cytology and frozen section, are hampered by poor sensitivity and lack standardized methodology. The one-step nuclei acid amplification (OSNA) assay is a rapid quantification of cytokeratin 19 mRNA. This prospective study compared an existing intraoperative imprint cytology protocol with the OSNA system. Methods Of the 110 prospectively recruited patients, 98 met the inclusion criteria with a total of 170 lymph nodes. Intraoperative sentinel nodes were serially sectioned and imprints made of each cut surface for cytological assessment. Alternate slices were submitted for OSNA while the remaining slices were for final histopathological evaluation with six hematoxylin and eosin levels and one AE1/AE3 immunoperoxidase stain of each slice. Results On histopathological analysis, 24.5% of patients (16.5% of nodes) had sentinel node metastases and 3.1% (2.4%) had isolated tumour cells. With isolated tumour cells cases taken as negative, the sensitivity of imprint cytology and OSNA compared with histopathology were 66.7% on patient basis (71.4% on per-node basis) and 95.8% (89.3%), respectively. One of 22 patients with macrometastases and two of three micrometastases were designated negative while five false-positive nodes were identified with OSNA, likely due to tissue allocation bias. Conclusion The OSNA assay is highly sensitive in comparison with imprint cytology and may be used effectively in the intraoperative setting. Clinical follow-up studies are warranted to further assess its use in routine practice.
- Published
- 2014
47. White paper: Uncertainty and variability in computational and mathematical models of cardiac physiology
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Mirams, G, Pathmanathan, P, Gray, RA, Challenor, P, and Clayton, RH
- Abstract
The Cardiac Physiome effort is one of the most mature and successful applications of mathematical and computational models for describing and advancing the understanding of physiology. After five decades of development, physiological cardiac models are poised to realise the promise of translational research via clinical applications such as drug development and patient specific approaches as well as ablation, cardiac resynchronisation, and contractility modulation therapies. For models to be included as a vital component of the decision process in safety critical applications, rigorous assessment of model credibility will be required. This White Paper describes one aspect of this process by identifying and classifying sources of variability and uncertainty in moels as well as their implications for the application and development of cardiac models. We stress the need to understand and quantify the sources of variability and uncertainty in model inputs, the impact of model structure and complexity, and their consequences for predictive model outputs. We propose that the future of the Cardiac Physiome should include a probabilistic approach to quantify the relationship of variability and uncertainty of model inputs and outputs.
- Published
- 2016
48. Uncertainty and variability in computational and mathematical models of cardiac physiology: Uncertainty and variability in cardiac models
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Mirams, Gary R., Pathmanathan, Pras, Gray, Richard A., Challenor, Peter, and Clayton, Richard H.
- Published
- 2016
49. Verification of computational models of cardiac electro-physiology
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Pras Pathmanathan and Richard A. Gray
- Subjects
Computational model ,Theoretical computer science ,Electro physiology ,business.industry ,Computer science ,Applied Mathematics ,Biomedical Engineering ,Solver ,Field (computer science) ,Software ,Mathematical equations ,Computational Theory and Mathematics ,Computer engineering ,Modeling and Simulation ,Verification and validation of computer simulation models ,Uncertainty quantification ,business ,Molecular Biology - Abstract
SUMMARY For computational models of cardiac activity to be used in safety-critical clinical decision-making, thorough and rigorous testing of the accuracy of predictions is required. The field of ‘verification, validation and uncertainty quantification’ has been developed to evaluate the credibility of computational predictions. The first stage, verification, is the evaluation of how well computational software correctly solves the underlying mathematical equations. The aim of this paper is to introduce novel methods for verifying multi-cellular electro-physiological solvers, a crucial first stage for solvers to be used with confidence in clinical applications. We define 1D–3D model problems with exact solutions for each of the monodomain, bidomain, and bidomain-with-perfusing-bath formulations of cardiac electro-physiology, which allow for the first time the testing of cardiac solvers against exact errors on fully coupled problems in all dimensions. These problems are carefully constructed so that they can be easily run using a general solver and can be used to greatly increase confidence that an implementation is correct, which we illustrate by testing one major solver, ‘Chaste’, on the problems. We then perform case studies on calculation verification (also known as solution verification) for two specific applications. We conclude by making several recommendations regarding verification in cardiac modelling. Copyright © 2013 John Wiley & Sons, Ltd.
- Published
- 2013
50. Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases
- Author
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Wang, Xue Yu, primary, Mahajan, Hema, additional, Dickinson, Nicole, additional, Cox, Carol, additional, Byth, Karen, additional, Bayly, Angela, additional, Cahill, Michael A., additional, and Pathmanathan, Nirmala, additional
- Published
- 2018
- Full Text
- View/download PDF
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