Search

Your search keyword '"Park, Su Hyun"' showing total 17 results
Start Over Author "Park, Su Hyun" Publisher wiley
17 results on '"Park, Su Hyun"'

11. Inhibition of TNF‐α‐Induced MUC5AC Mucin Gene Expression and Production by Wogonin Through the Inactivation of NF‐κB Signaling in Airway Epithelial Cells

Author

Sikder, Md. Asaduzzaman, primary, Lee, Hyun Jae, additional, Mia, Md. Zakaria, additional, Park, Su Hyun, additional, Ryu, Jiho, additional, Kim, Jang‐Hyun, additional, Min, Sang Yeon, additional, Hong, Jang‐Hee, additional, Seok, Jeong Ho, additional, and Lee, Choong Jae, additional

Published
2013
Full Text
View/download PDF

15. RiceIndeterminate 1(OsId1) is necessary for the expression ofEhd1(Early heading date 1) regardless of photoperiod

Author

Park, Soon Ju, primary, Kim, Song Lim, additional, Lee, Shinyoung, additional, Je, Byoung Il, additional, Piao, Hai Long, additional, Park, Sung Han, additional, Kim, Chul Min, additional, Ryu, Choong-Hwan, additional, Park, Su Hyun, additional, Xuan, Yuan-hu, additional, Colasanti, Joseph, additional, An, Gynheung, additional, and Han, Chang-deok, additional

Published
2008
Full Text
View/download PDF

16. Molecular analysis of rice plants harboring an Ac/Ds transposable element-mediated gene trapping system

Author

Chin, Hang Gyeong, primary, Choe, Mi Sook, additional, Lee, Sung-Ho, additional, Park, Sung Han, additional, Park, Su Hyun, additional, Koo, Ja Choon, additional, Kim, No Youl, additional, Lee, Jeung Joo, additional, Oh, Byeong Geun, additional, Yi, Gi Hwan, additional, Kim, Soon Chul, additional, Choi, Hae Chune, additional, Cho, Moo Je, additional, and Han, Chang-deok, additional

Published
1999
Full Text
View/download PDF

17. Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells.

Author

Sikder MA, Lee HJ, Mia MZ, Park SH, Ryu J, Kim JH, Min SY, Hong JH, Seok JH, and Lee CJ

Subjects
Cell Line, Tumor, Cyclooxygenase 2 metabolism, Dose-Response Relationship, Drug, Down-Regulation drug effects, Epithelial Cells metabolism, Gene Expression Regulation drug effects, Humans, I-kappa B Kinase metabolism, Mucin 5AC genetics, NF-kappa B metabolism, Phosphorylation, Proto-Oncogene Proteins c-bcl-2 metabolism, Transcription Factor RelA metabolism, Tumor Necrosis Factor-alpha pharmacology, Epithelial Cells drug effects, Flavanones pharmacology, Mucin 5AC metabolism, NF-kappa B antagonists & inhibitors, Signal Transduction drug effects
Abstract

In this study, we investigated whether wogonin significantly affects MUC5AC mucin gene expression and production in human airway epithelial cells. Confluent NCI-H292 cells were pretreated with wogonin for 30 min and then stimulated with tumor necrosis factor-α (TNF-α) for 24 h or the indicated periods. The MUC5AC mucin gene expression and mucin protein production were measured by RT-PCR and ELISA, respectively. We found that incubation of NCI-H292 cells with wogonin significantly inhibited mucin production and down-regulated MUC5AC gene expression induced by TNF-α in a dose-dependent fashion. To elucidate the action mechanism of wogonin, effect of wogonin on TNF-α-induced NF-κB signaling pathway was investigated by western blot analysis. Wogonin inhibited NF-κB activation induced by TNF-α. Inhibition of IKK by wogonin led to the suppression of IκB phosphorylation and degradation, p65 nuclear translocation and NF-κB-regulated gene expression. This, in turn, led to the down-regulation of MUC5AC protein production in NCI-H292 cells. Wogonin also inhibited the gene products involved in cell survival (Bcl-2) and proliferation (cyclooxygenase-2). These results suggest that wogonin inhibits the NF-κB signaling pathway, which may explain its role in the inhibition of MUC5AC mucin gene expression and production., (Copyright © 2013 John Wiley & Sons, Ltd.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results