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46 results on '"Park, Min Ho"'

1. Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis

Author

Shin, Gu‐Choul, primary, Lee, Hyeong Min, additional, Kim, Nayeon, additional, Hur, Jihyeon, additional, Yoo, Sang‐Ku, additional, Park, Yun Sun, additional, Park, Hyung Soon, additional, Ryu, Dongryeol, additional, Park, Min‐Ho, additional, Park, Jung Hee, additional, Seo, Sang‐Uk, additional, Choi, Leo Sungwong, additional, Madsen, Martin Rønn, additional, Feigh, Michael, additional, Kim, Kwang Pyo, additional, and Kim, Kyun‐Hwan, additional

Published
2024
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9. Artificial Synapses: Dimensionality Dependent Plasticity in Halide Perovskite Artificial Synapses for Neuromorphic Computing (Adv. Electron. Mater. 9/2019)

Author

Kim, Sung‐Il, primary, Lee, Yeongjun, additional, Park, Min‐Ho, additional, Go, Gyeong‐Tak, additional, Kim, Young‐Hoon, additional, Xu, Wentao, additional, Lee, Hyeon‐Dong, additional, Kim, Hobeom, additional, Seo, Dae‐Gyo, additional, Lee, Wanhee, additional, and Lee, Tae‐Woo, additional

Published
2019
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13. Fine Control of Perovskite Crystallization and Reducing Luminescence Quenching Using Self‐Doped Polyaniline Hole Injection Layer for Efficient Perovskite Light‐Emitting Diodes

Author

Ahn, Soyeong, primary, Park, Min‐Ho, additional, Jeong, Su‐Hun, additional, Kim, Young‐Hoon, additional, Park, Jinwoo, additional, Kim, Sungjin, additional, Kim, Hobeom, additional, Cho, Himchan, additional, Wolf, Christoph, additional, Pei, Mingyuan, additional, Yang, Hoichang, additional, and Lee, Tae‐Woo, additional

Published
2018
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24. Validation of a liquid chromatography-triple quadrupole mass spectrometric method for the determination of 5-nitro-5′-hydroxy-indirubin-3′-oxime (AGM-130) in human plasma and its application to microdose clinical trial

Author

Park, Min-Ho, primary, Lee, Yun Young, additional, Cho, Kyung Hee, additional, La, Sookie, additional, Lee, Hee Joo, additional, Yim, Dong-Seok, additional, Ban, Sooho, additional, Park, Moon-Young, additional, Kim, Yong-Chul, additional, Kim, Yoon-Gyoon, additional, and Shin, Young G., additional

Published
2015
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31. Determinants of suicidal ideation in patients with breast cancer

Author

Kim, Jae‐Min, primary, Jang, Ji‐Eun, additional, Stewart, Robert, additional, Kim, Seon‐Young, additional, Kim, Sung‐Wan, additional, Kang, Hee‐Ju, additional, Shin, Il‐Seon, additional, Park, Min‐Ho, additional, Yoon, Jung‐Han, additional, and Yoon, Jin‐Sang, additional

Published
2013
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38. Synthesis of Large‐Area Graphene Layers on Poly‐Nickel Substrate by Chemical Vapor Deposition: Wrinkle Formation

Author

Chae, Seung Jin, primary, Güneş, Fethullah, additional, Kim, Ki Kang, additional, Kim, Eun Sung, additional, Han, Gang Hee, additional, Kim, Soo Min, additional, Shin, Hyeon‐Jin, additional, Yoon, Seon‐Mi, additional, Choi, Jae‐Young, additional, Park, Min Ho, additional, Yang, Cheol Woong, additional, Pribat, Didier, additional, and Lee, Young Hee, additional

Published
2009
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42. Symptom clusters and quality of life in breast cancer survivors after cancer treatment in a tertiary hospital in Korea.

Author

Nho JH, Kim SR, Park MH, and Kweon SS

Subjects
Adult, Aged, Anorexia epidemiology, Anxiety epidemiology, Anxiety psychology, Cancer Survivors psychology, Cluster Analysis, Constipation epidemiology, Cross-Sectional Studies, Depression epidemiology, Depression psychology, Dyspnea epidemiology, Fatigue epidemiology, Female, Humans, Middle Aged, Nausea epidemiology, Pain epidemiology, Principal Component Analysis, Republic of Korea epidemiology, Sleep Initiation and Maintenance Disorders epidemiology, Syndrome, Tertiary Care Centers, Vomiting epidemiology, Breast Neoplasms therapy, Cancer Survivors statistics & numerical data, Quality of Life
Abstract

We investigated the symptom clusters and effects of symptom clusters on the quality of life of Korean breast cancer survivors. We recruited 241 breast cancer survivors and collected cross-sectional data on their symptoms. To determine inter-relationships among symptoms, a principal component analysis with varimax rotation was performed based on the patient's symptoms (fatigue, nausea/vomiting, pain, dyspnoea, insomnia, appetite loss, constipation, anxiety, depression, systemic therapy side effects, breast symptoms and arm symptoms). The first symptom cluster consisted of psychological (anxiety and depression) and general (appetite loss, fatigue, insomnia and dyspnoea) symptoms, whereas the second symptom cluster consisted of physical (arm symptom, breast symptom, pain and systemic therapy side effects) and gastrointestinal (nausea/vomiting and constipation) symptoms. Subgroup cluster analysis showed that breast cancer survivors with higher-scoring symptoms had significantly poorer quality of life in both psychological-general symptom cluster and physical-gastrointestinal symptom cluster subgroups, with subgroup-specific patterns. The symptom clusters differed depending on stage and functional status of breast cancer survivors. Breast cancer survivors may have a specific pattern of symptom clusters. Some symptom clusters may have a negative impact on the quality of life. Identifying symptom clusters of breast cancer survivors may have clinical implications by improving symptom management., (© 2018 John Wiley & Sons Ltd.)

Published
2018
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43. Quantification and application of a liquid chromatography-tandem mass spectrometric method for the determination of WKYMVm peptide in rat using solid-phase extraction.

Author

Lee BI, Park MH, Heo SC, Park Y, Shin SH, Byeon JJ, Kim JH, and Shin YG

Subjects
Animals, Linear Models, Oligopeptides isolation & purification, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Chromatography, Liquid methods, Oligopeptides blood, Solid Phase Extraction methods, Tandem Mass Spectrometry methods
Abstract

A liquid chromatographic-electrospray ionization-time-of-flight/mass spectrometric (LC-ESI-TOF/MS) method was developed and applied for the determination of WKYMVm peptide in rat plasma to support preclinical pharmacokinetics studies. The method consisted of micro-elution solid-phase extraction (SPE) for sample preparation and LC-ESI-TOF/MS in the positive ion mode for analysis. Phenanthroline (10 mg/mL) was added to rat blood immediately for plasma preparation followed by addition of trace amount of 2 m hydrogen chloride to plasma before SPE for stability of WKYMVm peptide. Then sample preparation using micro-elution SPE was performed with verapamil as an internal standard. A quadratic regression (weighted 1/concentration 2 ), with the equation y = ax 2  + bx + c was used to fit calibration curves over the concentration range of 3.02-2200 ng/mL for WKYMVm peptide. The quantification run met the acceptance criteria of ±25% accuracy and precision values. For quality control samples at 15, 165 and 1820 ng/mL from the quantification experiment, the within-run and the between-run accuracy ranged from 92.5 to 123.4% with precision values ≤15.1% for WKYMVm peptide from the nominal values. This novel LC-ESI-TOF/MS method was successfully applied to evaluate the pharmacokinetics of WKYMVm peptide in rat plasma., (Copyright © 2017 John Wiley & Sons, Ltd.)

Published
2018
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44. Qualification and application of a liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of trastuzumab in rat plasma.

Author

Park MH, Lee MW, and Shin YG

Subjects
Animals, Calibration, Dogs, Humans, Limit of Detection, Macaca fascicularis, Mice, Rats, Sprague-Dawley, Antineoplastic Agents blood, Chromatography, High Pressure Liquid methods, Tandem Mass Spectrometry methods, Trastuzumab blood
Abstract

An liquid chromatography-quadrupole time-of-flight (QqTOF) mass spectrometric method was developed for the determination of humanized or human monoclonal antibodies in rat plasma at the early drug discovery stage. Trastuzumab was used as a model monoclonal antibody. The method consisted of immunoprecipitation followed by tryptic digestion for sample preparation and LC-TOF-MS/MS analysis of specific signature peptides in the positive ion mode using electrospray ionization for analysis. A stable isotope-labeled signature peptide was also used as internal standard. A quadratic regression (weighted 1/concentration(2) ), with an equation y = ax(2)  + bx + c, was used to fit calibration curves over the concentration range of 0.500-100 µg/mL for trastuzumab. Samples from a pharmacokinetic study in rat were analyzed by this qualified LC-TOF-MS/MS method and concentrations were compared with those generated by enzyme linked immunosorbent assays method. The LC-TOF-MS/MS method was accurate and precise, with quantitative results comparable with those of ELISA. The qualification run met the acceptance criteria of ±25% accuracy and precision values for quality control samples. Within-run accuracy ranged from 1.53 to 9.20% with precision values ≤10.29%. This LC-TOF-MS/MS method approach could be used as a complementary method for humanized or human monoclonal antibodies at the early drug discovery stage., (Copyright © 2015 John Wiley & Sons, Ltd.)

Published
2016
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45. Validation of a liquid chromatography-triple quadrupole mass spectrometric method for the determination of 5-nitro-5'-hydroxy-indirubin-3'-oxime (AGM-130) in human plasma and its application to microdose clinical trial.

Author

Park MH, Lee YY, Cho KH, La S, Lee HJ, Yim DS, Ban S, Park MY, Kim YC, Kim YG, and Shin YG

Subjects
Chromatography, Liquid methods, Cyclin-Dependent Kinases antagonists & inhibitors, Female, Humans, Indoles pharmacokinetics, Linear Models, Liquid-Liquid Extraction, Male, Oximes pharmacokinetics, Protein Kinase Inhibitors administration & dosage, Protein Kinase Inhibitors blood, Protein Kinase Inhibitors pharmacokinetics, Reproducibility of Results, Sensitivity and Specificity, Tandem Mass Spectrometry methods, Indoles administration & dosage, Indoles blood, Oximes administration & dosage, Oximes blood
Abstract

A liquid chromatography-triple quadrupole mass spectrometric (LC-MS/MS) method was developed and validated for the determination of 5-nitro-5'-hydroxy-indirubin-3'-oxime (AGM-130) in human plasma to support a microdose clinical trial. The method consisted of a liquid-liquid extraction for sample preparation and LC-MS/MS analysis in the positive ion mode using TurboIonSpray(TM) for analysis. d3 -AGM-130 was used as the internal standard. A linear regression (weighted 1/concentration) was used to fit calibration curves over the concentration range of 10-2000 pg/mL for AGM-130. There were no endogenous interference components in the blank human plasma tested. The accuracy at the lower limit of quantitation was 96.6% with a precision (coefficient of variation, CV) of 4.4%. For quality control samples at 30, 160 and 1600 pg/mL, the between run CV was ≤5.0 %. Between-run accuracy ranged from 98.1 to 101.0%. AGM-130 was stable in 50% acetonitrile for 168 h at 4°C and 6 h at room temperature. AGM-130 was also stable in human plasma at room temperature for 6 h and through three freeze-thaw cycles. The variability of selected samples for the incurred sample reanalysis was ≤12.7% when compared with the original sample concentrations. This validated LC-MS/MS method for determination of AGM-130 was used to support a phase 0 microdose clinical trial., (Copyright © 2015 John Wiley & Sons, Ltd.)

Published
2016
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46. Religiosity, depression, and quality of life in Korean patients with breast cancer: a 1-year prospective longitudinal study.

Author

Jang JE, Kim SW, Kim SY, Kim JM, Park MH, Yoon JH, Shin HY, Kang HJ, Bae KY, Shin IS, and Yoon JS

Subjects
Adult, Aged, Anxiety psychology, Asian People psychology, Breast Neoplasms ethnology, Breast Neoplasms surgery, Depression psychology, Female, Follow-Up Studies, Humans, Mastectomy, Middle Aged, Neuropsychological Tests, Prevalence, Prospective Studies, Psychiatric Status Rating Scales, Republic of Korea epidemiology, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Adaptation, Psychological, Anxiety ethnology, Breast Neoplasms psychology, Depression ethnology, Quality of Life psychology, Religion
Abstract

Objective: To investigate the association among religiosity and depression, anxiety, and quality of life in women with breast cancer., Method: The sample consisted of 284 patients with breast cancer who were undergoing surgery. They were assessed with the following instruments at baseline and at 1 year after surgery: the Duke Religious Index (DRI), the Montgomery-Asberg Depression Rating Scale, the Hospital Anxiety Depression Scale, and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Depression was diagnosed with the Mini International Neuropsychiatric Interview., Results: The prevalence of depression at baseline and at 1 year was 22.5% and 16.5%, respectively. The religious groups did not differ significantly with respect to the prevalence of depression or scores on psychiatric measures at either baseline or at 1 year. The prevalence of depression significantly decreased only in the Protestant group, from 30.1% to 15.7%. Scores on the DRI were significantly negatively correlated with scores on all of the anxiety and depression scales at 1 year after surgery in this group. In contrast, scores on the religious activity subscale of the DRI were significantly positively correlated with scores on the Hospital Anxiety Depression Scale at baseline or at 1 year among Catholic participants. The DRI scores of Protestant respondents were significantly positively correlated with scores on the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at 1 year after surgery., Conclusion: Religiosity plays an important role in the emotional state and quality of life of Korean women with breast cancer. However, its clinical meaning may differ according to the type of religious affiliation and the stage of illness., (Copyright © 2012 John Wiley & Sons, Ltd.)

Published
2013
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